Zobrazeno 1 - 10
of 400
pro vyhledávání: '"Evangelia G Kranias"'
Autor:
Evan Onusko, Michael R McDermott, Nathan Robbins, Guansheng Liu, Evangelia G Kranias, Jack Rubinstein, Sheryl E Koch
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0230386 (2020)
Probenecid has been used for decades in the treatment of gout but recently has also been found to improve outcomes in patients with heart failure via stimulation of the transient receptor potential vanilloid 2 (TRPV2) channel in cardiomyocytes. This
Externí odkaz:
https://doaj.org/article/594e8b50cc3f4a2cace73ed4c6e98bca
Autor:
Benjamin Klocke, Aikaterini Britzolaki, Joseph Saurine, Hayden Ott, Kylie Krone, Kiara Bahamonde, Connor Thelen, Christos Tzimas, Despina Sanoudou, Evangelia G. Kranias, Pothitos M. Pitychoutis
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract The thalamic reticular nucleus (TRN) is a brain region that influences vital neurobehavioral processes, including executive functioning and the generation of sleep rhythms. TRN dysfunction underlies hyperactivity, attention deficits, and sle
Externí odkaz:
https://doaj.org/article/111c82fc7a3544e4b516588cc3b18349
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80867 (2013)
In human and experimental heart failure, the activity of the type 1 phosphatase is significantly increased, associated with dephosphorylation of phospholamban, inhibition of the sarco(endo)plasmic reticulum Ca(2+) transport ATPase (SERCA2a) and depre
Externí odkaz:
https://doaj.org/article/5f70732828db494cac6c47bed0b7f41b
Autor:
Tracy J Pritchard, Yoshiaki Kawase, Kobra Haghighi, Ahmad Anjak, Wenfeng Cai, Min Jiang, Persoulla Nicolaou, George Pylar, Ioannis Karakikes, Kleopatra Rapti, Jack Rubinstein, Roger J Hajjar, Evangelia G Kranias
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e80717 (2013)
Impaired sarcoplasmic reticulum calcium cycling and depressed contractility are key characteristics in heart failure. Defects in sarcoplasmic reticulum function are characterized by decreased SERCA2a Ca-transport that is partially attributable to dep
Externí odkaz:
https://doaj.org/article/914668e255514939a6d21b2a33846d2f
Autor:
Chang Sik Park, Hyeseon Cha, Eun Jeong Kwon, Dongtak Jeong, Roger J Hajjar, Evangelia G Kranias, Chunghee Cho, Woo Jin Park, Do Han Kim
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43282 (2012)
Histidine-rich calcium binding protein (HRC) is located in the lumen of sarcoplasmic reticulum (SR) that binds to both triadin (TRN) and SERCA affecting Ca(2+) cycling in the SR. Chronic overexpression of HRC that may disrupt intracellular Ca(2+) hom
Externí odkaz:
https://doaj.org/article/0b519156a7014028a1c1127c55f20273
Autor:
Simona Boncompagni, Monique Thomas, Jose R Lopez, Paul D Allen, Qunying Yuan, Evangelia G Kranias, Clara Franzini-Armstrong, Claudio F Perez
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e39962 (2012)
Triadin (Tdn) and Junctin (Jct) are structurally related transmembrane proteins thought to be key mediators of structural and functional interactions between calsequestrin (CASQ) and ryanodine receptor (RyRs) at the junctional sarcoplasmic reticulum
Externí odkaz:
https://doaj.org/article/1d674a656506462b9ca79f69251ad0ae
Autor:
Xiaowei Zhang, Xiaohong Wang, Hongyan Zhu, Evangelia G Kranias, Yaoliang Tang, Tianqing Peng, Jiang Chang, Guo-Chang Fan
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e32765 (2012)
Heat shock proteins (Hsps) are well appreciated as intrinsic protectors of cardiomyocytes against numerous stresses. Recent studies have indicated that Hsp20 (HspB6), a small heat shock protein, was increased in blood from cardiomyopathic hamsters. H
Externí odkaz:
https://doaj.org/article/43ae840647fb4690882cc19a3e12287a
Autor:
Peter J Mohler, Jane A Healy, Hui Xue, Annibale A Puca, Crystal F Kline, R Rand Allingham, Evangelia G Kranias, Howard A Rockman, Vann Bennett
Publikováno v:
PLoS ONE, Vol 2, Iss 10, p e1051 (2007)
Here we report the unexpected finding that specific human ANK2 variants represent a new example of balanced human variants. The prevalence of certain ANK2 (encodes ankyrin-B) variants range from 2 percent of European individuals to 8 percent in indiv
Externí odkaz:
https://doaj.org/article/5b4cf91b56634b5aa5ef22c09bfdeaba
Autor:
Jaydev Dave, Nour Raad, Nishka Mittal, Lu Zhang, Anthony Fargnoli, Jae Gyun Oh, Maria Elisabetta Savoia, Jens Hansen, Marika Fava, Xiaoke Yin, Konstantinos Theofilatos, Delaine Ceholski, Erik Kohlbrenner, Dongtak Jeong, Lauren Wills, Mathieu Nonnenmacher, Kobra Haghighi, Kevin D Costa, Irene C Turnbull, Manuel Mayr, Chen-Leng Cai, Evangelia G Kranias, Fadi G Akar, Roger J Hajjar, Francesca Stillitano
Publikováno v:
Cardiovasc Res
Aims A mutation in the phospholamban (PLN) gene, leading to deletion of Arg14 (R14del), has been associated with malignant arrhythmias and ventricular dilation. Identifying pre-symptomatic carriers with vulnerable myocardium is crucial because arrhyt
Autor:
Mohit Kumar, Kobra Haghighi, Sheryl Koch, Jack Rubinstein, Francesca Stillitano, Roger J. Hajjar, Evangelia G. Kranias, Sakthivel Sadayappan
Publikováno v:
International Journal of Molecular Sciences
Volume 24
Issue 3
Pages: 2675
Volume 24
Issue 3
Pages: 2675
Phospholamban (PLN) is a major regulator of cardiac contractility, and human mutations in this gene give rise to inherited cardiomyopathies. The deletion of Arginine 14 is the most-prevalent cardiomyopathy-related mutation, and it has been linked to