Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Evangelia A Papakonstanti"'
Publikováno v:
Frontiers in Oncology, Vol 5 (2015)
The role of PTEN as a tumour suppressor has been for a long time attributed to its lipid phosphatase activity against PI(3,4,5)P3, the phospholipid product of the class I PI3Ks. Besides its traditional role as a lipid phosphatase at the plasma membra
Externí odkaz:
https://doaj.org/article/10e7cad394c3413ebb143d4c96122948
Autor:
Niki Tzenaki, Lydia Xenou, Evangelia Goulielmaki, Anna Tsapara, Irene Voudouri, Angelika Antoniou, George Valianatos, Maria Tzardi, Eelco De Bree, Aikaterini Berdiaki, Antonios Makrigiannakis, Evangelia A. Papakonstanti
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-18 (2024)
Abstract Malignant melanoma is the most aggressive and deadly skin cancer with an increasing incidence worldwide whereas SCC is the second most common non-melanoma human skin cancer with limited treatment options. Here we show that the development an
Externí odkaz:
https://doaj.org/article/8211276951d24ee48433c2253a37f57a
Autor:
Aikaterini Vergetaki, Udo Jeschke, Thomas Vrekoussis, Eirini Taliouri, Luca Sabatini, Evangelia A Papakonstanti, Antonis Makrigiannakis
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e114229 (2014)
Endometriosis is an inflammatory disease of women of reproductive age featured by the presence of ectopic endometrium and is strongly related to infertility. Galectins, carbonhydrate-binding proteins, have been found to have pro- or anti-inflammatory
Externí odkaz:
https://doaj.org/article/6223fa5dfcb24276a12db461faaaaa0a
Publikováno v:
Frontiers in Oncology, Vol 3 (2013)
Class IA PI3Ks consists of three isoforms of the p110 catalytic subunit designated p110a, p110b and p110d which are encoded by three separate genes. Gain-of-function mutations on PIK3CA gene encoding for p110a isoform have been detected in a wide var
Externí odkaz:
https://doaj.org/article/876a370497e548779f5a3d02d5077628
Autor:
Aikaterini Vergetaki, Udo Jeschke, Thomas Vrekoussis, Eirini Taliouri, Luca Sabatini, Evangelia A Papakonstanti, Antonis Makrigiannakis
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e62313 (2013)
Endometriosis is considered as a benign aseptic inflammatory disease, characterised by the presence of ectopic endometrium-like tissue. Its symptoms (mostly pain and infertility) are reported as constant stressors. Corticotropin releasing hormone (CR
Externí odkaz:
https://doaj.org/article/ab28bfabaea64504a5fe952891914b35
Autor:
Britta J Eickholt, Aminul I Ahmed, Meirion Davies, Evangelia A Papakonstanti, Wayne Pearce, Michelle L Starkey, Antonio Bilancio, Anna C Need, Andrew J H Smith, Susan M Hall, Frank P Hamers, Karl P Giese, Elizabeth J Bradbury, Bart Vanhaesebroeck
Publikováno v:
PLoS ONE, Vol 2, Iss 9, p e869 (2007)
The expression and function of the 8 distinct catalytic isoforms of PI 3-kinase (PI3K) in the nervous system are unknown. Whereas most PI3Ks have a broad tissue distribution, the tyrosine kinase-linked p110delta isoform has previously been shown to b
Externí odkaz:
https://doaj.org/article/cae2cd508ba64fa2aff4fed22a507393
Publikováno v:
Clinical science (London, England : 1979). 134(12)
From the time of first characterization of PI3K as a heterodimer made up of a p110 catalytic subunit and a regulatory subunit, a wealth of evidence have placed the class IA PI3Ks at the forefront of drug development for the treatment of various disea
Autor:
Amy R. MacQueen, Michael Lahn, Anna Tsapara, L. Van der Veen, Pritom Shah, Evangelia A. Papakonstanti, Zoë Johnson
Publikováno v:
Annals of Oncology. 30:vii27
Background Inhibiting PI3Kδ preferentially targets regulatory T cells and myeloid derived suppressor cells, breaking tumour-induced immune tolerance and restoring anti-tumour immunity. Bioinformatics and protein expression studies have shown that PI
Autor:
Niki Tzenaki, Margarita Andreou, Eelco de Bree, Antonis Makrigiannakis, Miriam Bermudez-Brito, Evangelia Goulielmaki, Maria Tzardi, Evangelia A. Papakonstanti, Eleftheria Tsentelierou
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 9, Iss 6, Pp 1-15 (2018)
Cell Death and Disease, Vol 9, Iss 6, Pp 1-15 (2018)
Patient selection for PI3K-targeted solid cancer treatment was based on the PIK3CA/PTEN mutational status. However, it is increasingly clear that this is not a good predictor of the response of breast cancer cells to the anti-proliferative effect of
Autor:
Michael Lahn, Lars van der Veen, Katherine Ewings, Pritom Shah, Anna Tsapara, Zoë Johnson, Evangelia A. Papakonstanti, Amy R. MacQueen
Publikováno v:
Cancer Research. 79:2692-2692
The Class I Phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) family is an attractive target class for the treatment of hematological and solid malignancies. In addition to the direct effects of PI3Kδ inhibition on B cell malignancies, inhibitin