An integrated approach towards the discovery of novel non-nucleoside Leishmania major pteridine reductase 1 inhibitors

Autor: Evandro Italo Macêdo de Souza, Marcelo Santos Castilho, Suellen Gonçalves da Silva, Drielli Gomes Vital-Fujii, Thamires Quadros Froes, Samuel Silva da Rocha Pita, Gustavo Henrique Goulart Trossini, Franco Henrique Andrade Leite

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Despite the fact that Leishmania ssp are pteridine auxotrophs, Dihydrofolate Reductase-Thymidylate Synthase (DHFR-TS) inhibitors are ineffective against Leishmania major. On the other hand Pteridine Reductase 1 (PTR1) inhibitors proved to be lethal t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d634f82e04cf7b7ad24f8212ef6f4cd0
https://pubmed.ncbi.nlm.nih.gov/28407565