Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Evan W. Weber"'
Autor:
Katalin Sandor, Peng Xu, Joseph A Fraietta, Stephan Grupp, Crystal L Mackall, Patrick Quinn, Martina Markovska, Yingshi Chen, Katherine P Mueller, Alexander E Doan, Andy Chen, Geoffrey Rouin, Bence Daniel, John Lattin, Brett Mozarsky, Jose Arias-Umana, Robert Hapke, Inyoung Jung, Dorota Klysz, Malek Bashti, Wenxi Zhang, Junior Hall, Caleb A Lareau, Elena Sotillo, Ansuman T Satpathy, Evan W Weber
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/217a9a8ee6f74a2fb315bf07253d21ba
Autor:
Aidan M. Tousley, Maria Caterina Rotiroti, Louai Labanieh, Lea Wenting Rysavy, Won-Ju Kim, Caleb Lareau, Elena Sotillo, Evan W. Weber, Skyler P. Rietberg, Guillermo Nicolas Dalton, Yajie Yin, Dorota Klysz, Peng Xu, Eva L. de la Serna, Alexander R. Dunn, Ansuman T. Satpathy, Crystal L. Mackall, Robbie G. Majzner
Publikováno v:
Nature. 615:507-516
Autor:
Crystal L. Mackall, Ronald D. Vale, Alexander R. Dunn, Peng Xu, Rachel C. Lynn, Johanna Theruvath, Volker Wiebking, Sang M. Nguyen, Sabine Heitzeneder, Rebecca M. Richards, Aidan M. Tousley, Evan W. Weber, Meena Kadapakkam, June H. Myklebust, Louai Labanieh, Vipul T. Vachharajani, Rui Dong, Elena Sotillo, Skyler P. Rietberg, Robbie G. Majzner
Supplemental Table 1 Supplementary Figures 1-10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::311f40ebf949712905c9428d4941d39e
https://doi.org/10.1158/2159-8290.22535654.v1
https://doi.org/10.1158/2159-8290.22535654.v1
Autor:
Crystal L. Mackall, Ronald D. Vale, Alexander R. Dunn, Peng Xu, Rachel C. Lynn, Johanna Theruvath, Volker Wiebking, Sang M. Nguyen, Sabine Heitzeneder, Rebecca M. Richards, Aidan M. Tousley, Evan W. Weber, Meena Kadapakkam, June H. Myklebust, Louai Labanieh, Vipul T. Vachharajani, Rui Dong, Elena Sotillo, Skyler P. Rietberg, Robbie G. Majzner
Insufficient reactivity against cells with low antigen density has emerged as an important cause of chimeric antigen receptor (CAR) T-cell resistance. Little is known about factors that modulate the threshold for antigen recognition. We demonstrate t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f70c30aecf09a358b25065ab2c1e623f
https://doi.org/10.1158/2159-8290.c.6547904.v1
https://doi.org/10.1158/2159-8290.c.6547904.v1
Autor:
Caroline Lamarche, Kirsten Ward-Hartstonge, Tian Mi, David T. S. Lin, Qing Huang, Andrew Brown, Karlie Edwards, Gherman E. Novakovsky, Christopher N. Qi, Michael S. Kobor, Caitlin C. Zebley, Evan W. Weber, Crystal L. Mackall, Megan K Levings
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Regulatory T cell (Treg) therapy is a promising approach to improve outcomes in transplantation and autoimmunity. In conventional T cell therapy, chronic stimulation can result in poor in vivo function, a phenomenon termed exhaustion. Whether or not
Autor:
Katherine A. Freitas, Julia A. Belk, Elena Sotillo, Patrick J. Quinn, Maria C. Ramello, Meena Malipatlolla, Bence Daniel, Katalin Sandor, Dorota Klysz, Jeremy Bjelajac, Peng Xu, Kylie A. Burdsall, Victor Tieu, Vandon T. Duong, Micah G. Donovan, Evan W. Weber, Howard Y. Chang, Robbie G. Majzner, Joaquin M. Espinosa, Ansuman T. Satpathy, Crystal L. Mackall
Publikováno v:
Science (New York, N.Y.). 378(6620)
T cells are the major arm of the immune system responsible for controlling and regressing cancers. To identify genes limiting T cell function, we conducted genome-wide CRISPR knockout screens in human chimeric antigen receptor (CAR) T cells. Top hits
Autor:
Katherine A. Freitas, Julia A. Belk, Elena Sotillo, Bence Daniel, Katalin Sandor, Dorota Klysz, Vandon T. Duong, Kylie Burdsall, Peng Xu, Meena Malipatlolla, Micah G. Donovan, Evan W. Weber, Robbie G. Majzner, Howard Y. Chang, Joaquin M. Espinosa, Ansuman T. Satpathy, Crystal L. Mackall
Adoptive T cell immune therapies mediate impressive clinical benefit in a fraction of patients, but anti-tumor effects are often limited by inadequate T cell potency. To identify genes limiting T cell effector function, we conducted genome-wide CRISP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2c4cb769a4ea3af40b5569af5a8250f
https://doi.org/10.1101/2022.09.02.506235
https://doi.org/10.1101/2022.09.02.506235
Autor:
Aidan M. Tousley, Maria Caterina Rotiroti, Louai Labanieh, Lea Wenting Rysavy, Skyler P. Rietberg, Eva L. de la Serna, Guillermo Nicolas Dalton, Dorota Klysz, Evan W. Weber, Won-Ju Kim, Peng Xu, Elena Sotillo, Alexander R. Dunn, Crystal L. Mackall, Robbie G. Majzner
Introductory paragraphWhile CAR T cells have altered the treatment landscape for B cell malignancies, the risk of on-target, off-tumor toxicity has hampered their development for solid tumors because most target antigens are shared with normal cells1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f74e6d8d737eca94d3cb85be7704a6e2
https://doi.org/10.1101/2022.06.17.496457
https://doi.org/10.1101/2022.06.17.496457
Autor:
David P. Sullivan, Tao A. Fu, Evan W. Weber, Annette P. Gonzalez, Prarthana J. Dalal, Nakisha S. Rutledge, William A. Muller
Publikováno v:
The FASEB Journal. 36
Autor:
Robert C. Jones, Surya Nagaraja, Ansuman T. Satpathy, Michelle Monje, Zinaida Good, Elena Sotillo, Howard Y. Chang, Peng Xu, Hima Anbunathan, Evan W. Weber, Crystal L. Mackall, Rachel C. Lynn, Charles F. A. de Bourcy, David Gennert, John Lattin, Jeffrey M. Granja, Robbie G. Majzner, Victor Tieu, Stephen R. Quake
Publikováno v:
Nature
Chimeric antigen receptor (CAR) T cells mediate anti-tumour effects in a small subset of patients with cancer1-3, but dysfunction due to T cell exhaustion is an important barrier to progress4-6. To investigate the biology of exhaustion in human T cel