Zobrazeno 1 - 10
of 232
pro vyhledávání: '"Evan W. Newell"'
Autor:
One B. Dintwe, Lamar Ballweber Fleming, Valentin Voillet, John McNevin, Aaron Seese, Anneta Naidoo, Saleha Omarjee, Linda-Gail Bekker, James G. Kublin, Stephen C. De Rosa, Evan W. Newell, Andrew Fiore-Gartland, Erica Andersen-Nissen, M. Juliana McElrath
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract A recent clinical trial demonstrated that Bacille Calmette-Guérin (BCG) revaccination of adolescents reduced the risk of sustained infection with Mycobacterium tuberculosis (M.tb). In a companion phase 1b trial, HVTN 602/Aeras A-042, we cha
Externí odkaz:
https://doaj.org/article/2df45c22cd2240a5b3efbdb7bbd386ce
Autor:
Aarthi Talla, Suhas V. Vasaikar, Gregory Lee Szeto, Maria P. Lemos, Julie L. Czartoski, Hugh MacMillan, Zoe Moodie, Kristen W. Cohen, Lamar B. Fleming, Zachary Thomson, Lauren Okada, Lynne A. Becker, Ernest M. Coffey, Stephen C. De Rosa, Evan W. Newell, Peter J. Skene, Xiaojun Li, Thomas F. Bumol, M. Juliana McElrath, Troy R. Torgerson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Long COVID or post-acute sequelae of SARS-CoV-2 (PASC) is a clinical syndrome featuring diverse symptoms that can persist for months following acute SARS-CoV-2 infection. The aetiologies may include persistent inflammation, unresolved tissue
Externí odkaz:
https://doaj.org/article/0a4ada69f9a3464f8bb10065779fdcc5
Autor:
Florian Schmidt, Hannah F. Fields, Yovita Purwanti, Ana Milojkovic, Syazwani Salim, Kan Xing Wu, Yannick Simoni, Antonella Vitiello, Daniel T. MacLeod, Alessandra Nardin, Evan W. Newell, Katja Fink, Andreas Wilm, Michael Fehlings
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113250- (2023)
Summary: Following viral infection, the human immune system generates CD8+ T cell responses to virus antigens that differ in specificity, abundance, and phenotype. A characterization of virus-specific T cell responses allows one to assess infection h
Externí odkaz:
https://doaj.org/article/d6eded1c85f54ddc91bb785b41d88019
Autor:
Celestine N. Wanjalla, Curtis L. Gabriel, Hubaida Fuseini, Samuel S. Bailin, Mona Mashayekhi, Joshua Simmons, Christopher M. Warren, David R. Glass, Jared Oakes, Rama Gangula, Erin Wilfong, Stephen Priest, Tecla Temu, Evan W. Newell, Suman Pakala, Spyros A. Kalams, Sara Gianella, David Smith, David G. Harrison, Simon A. Mallal, John R. Koethe
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Persons with HIV (PWH) on long-term antiretroviral therapy (ART) have a higher incidence and prevalence of cardiometabolic diseases attributed, in part, to persistent inflammation despite viral suppression. In addition to traditional risk factors, im
Externí odkaz:
https://doaj.org/article/2838cff8bda74656ae8136d9ff338554
Autor:
Shamin Li, Summer Zhuang, Antja Heit, Si-Lin Koo, Aaron C. Tan, I-Ting Chow, William W. Kwok, Iain Beehuat Tan, Daniel S.W. Tan, Yannick Simoni, Evan W. Newell
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
Tumor-specific T cells likely underpin effective immune checkpoint-blockade therapies. Yet, most studies focus on Treg cells and CD8+ tumor-infiltrating lymphocytes (TILs). Here, we study CD4+ TILs in human lung and colorectal cancers and observe tha
Externí odkaz:
https://doaj.org/article/cf73d279a12043e098c3dbbed9b3b8db
Autor:
Carla Claser, Samantha Yee Teng Nguee, Akhila Balachander, Shanshan Wu Howland, Etienne Becht, Bavani Gunasegaran, Siddesh V. Hartimath, Audrey W. Q. Lee, Jacqueline Theng Theng Ho, Chee Bing Ong, Evan W. Newell, Julian Goggi, Lai Guan Ng, Laurent Renia
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Severe malaria can be associated with respiratory complications. Here, the authors show that malaria-associated pulmonary vascular damage is a consequence of IFNγ-activated lung endothelial cells capturing, processing, and cross-presenting malaria p
Externí odkaz:
https://doaj.org/article/1fc2aedd388244a98e0a91adeebd988e
Autor:
Michael Fehlings, Suchit Jhunjhunwala, Marcin Kowanetz, William E. O’Gorman, Priti S. Hegde, Hermi Sumatoh, Boon Heng Lee, Alessandra Nardin, Etienne Becht, Susan Flynn, Marcus Ballinger, Evan W. Newell, Mahesh Yadav
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-15 (2019)
Abstract Background There is strong evidence that immunotherapy-mediated tumor rejection can be driven by tumor-specific CD8+ T cells reinvigorated to recognize neoantigens derived from tumor somatic mutations. Thus, the frequencies or characteristic
Externí odkaz:
https://doaj.org/article/521c2f3238b047f6a7391405547e902b
Autor:
Jose Antonio Reales-Calderon, Gloria H. W. Tso, Alrina S. M. Tan, Pei Xiang Hor, Julia Böhme, Karen W. W. Teng, Evan W. Newell, Amit Singhal, Norman Pavelka
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Serial passaging of the human fungal pathogen Candida albicans in the gastrointestinal tract of antibiotics-treated mice selects for virulence-attenuated strains. These gut-evolved strains protect the host from infection by a wide range of pathogens
Externí odkaz:
https://doaj.org/article/b78244ca41df4506bafd59ca00f923e2
Autor:
Angeline Rouers, Melissa Hui Yen Chng, Bernett Lee, Menaka P. Rajapakse, Kaval Kaur, Ying Xiu Toh, Durgalakshmi Sathiakumar, Thomas Loy, Tun-Linn Thein, Vanessa W.X. Lim, Amit Singhal, Tsin Wen Yeo, Yee-Sin Leo, Kalpit A. Vora, Danilo Casimiro, Bing Lim, Lisa Tucker-Kellogg, Laura Rivino, Evan W. Newell, Katja Fink
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 5, Pp 100278- (2021)
Summary: Prior immunological exposure to dengue virus can be both protective and disease-enhancing during subsequent infections with different dengue virus serotypes. We provide here a systematic, longitudinal analysis of B cell, T cell, and antibody
Externí odkaz:
https://doaj.org/article/f584c5014186468ab29c7e9b13295ce9
Autor:
Joe Yeong, Jeffrey Chun Tatt Lim, Bernett Lee, Huihua Li, Clara Chong Hui Ong, Aye Aye Thike, Wei Hseun Yeap, Yi Yang, Ansel Yi Herh Lim, Timothy Kwang Yong Tay, Jin Liu, Siew-Cheng Wong, Jinmiao Chen, Elaine Hsuen Lim, Jabed Iqbal, Rebecca Dent, Evan W. Newell, Puay Hoon Tan
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-13 (2019)
Abstract The role of programmed cell death protein-1 (PD-1)/programmed cell death ligand 1 (PD-L1) in triple negative breast cancer (TNBC) remains to be fully understood. In this study, we investigated the role of PD-1 as a prognostic marker for TNBC
Externí odkaz:
https://doaj.org/article/35978560b7ed430d90205d61ba30773f