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Autor:
Nancy M. Kinchla, Michael L. Grossbard, Guanxian Xu, Selwyn J. Hurwitz, Charles L. Shapiro, Richard Stone, Evan Vosburg, Jeffrey G. Supko, Mark S. Huberman, Deborah Toppmeyer, Eric J. Rubin, Lowell E. Schnipper, Dee Rodriguez, Margaret Bryant, Joseph Paul Eder, Donald Kufe, Lawrence N. Shulman, Thomas J. Lynch
Publikováno v:
Annals of the New York Academy of Sciences. 803
9-Amino-20(S)-camptothecin (9-AC) is an analog of camptothecin with limited water solubility which has shown significant preclinical activity in a variety of human solid tumor xenografts. A Phase I trial using a soluble formulation of 9-AC, given as