Zobrazeno 1 - 10
of 393
pro vyhledávání: '"Evan T. Keller"'
Autor:
Jianming Yang, Geng Pei, Xuan Sun, Yawen Xiao, Chunhui Miao, Lu Zhou, Bangmao Wang, Liu Yang, Mingyu Yu, Zhi-Song Zhang, Evan T. Keller, Zhi Yao, Quan Wang
Publikováno v:
Microbiome, Vol 10, Iss 1, Pp 1-22 (2022)
Abstract Background The pathogenesis of inflammatory bowel diseases (IBD) is multifactorial, and diagnostic and treatment strategies for IBD remain to be developed. RhoB regulates multiple cell functions; however, its role in colitis is unexplored. R
Externí odkaz:
https://doaj.org/article/a60ca0212ce24d88a5ec831eaf32341e
Autor:
Patricia M. Schnepp, Aqila Ahmed, June Escara-Wilke, Jinlu Dai, Greg Shelley, Jill Keller, Atsushi Mizokami, Evan T. Keller
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-14 (2021)
Abstract Background Overcoming drug resistance is critical for increasing the survival rate of prostate cancer (PCa). Docetaxel is the first cytotoxic chemotherapeutical approved for treatment of PCa. However, 99% of PCa patients will develop resista
Externí odkaz:
https://doaj.org/article/d20bcba51bc24959b570b2ddf87858d9
Autor:
Chunhui Miao, Mingyu Yu, Geng Pei, Zhenyi Ma, Lisong Zhang, Jianming Yang, Junqiang Lv, Zhi-Song Zhang, Evan T. Keller, Zhi Yao, Quan Wang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Bacterial invasion can lead to multiple host cell responses. Here, the authors show that in a model of uropathogenic E. coli, RhoB is upregulated and induces autophagosome formation in a complex with Beclin1 and Hsp90, promoting bacterial clearance.
Externí odkaz:
https://doaj.org/article/6566a1096e0b4b0b8b6e482feb14534a
Autor:
Yi Lu, Yuanpu Peter Di, Ming Chang, Xin Huang, Qiuyan Chen, Ni Hong, Beth A. Kahkonen, Marissa E. Di, Chunyan Yu, Evan T. Keller, Jian Zhang
Publikováno v:
Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-16 (2021)
Abstract Background Cigarette smoking constitutes a major lifestyle risk factor for osteoporosis and hip fracture. It is reported to impair the outcome of many clinical procedures, such as wound infection treatment and fracture healing. Importantly,
Externí odkaz:
https://doaj.org/article/e47cfc0f9424458e860ae75bd682e2da
Autor:
Koh Meng Aw Yong, Eric Horst, Dylan Neale, Sonya Royzenblat, Joerg Lahann, Colin Greineder, Megan Weivoda, Geeta Mehta, Evan T. Keller
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
The bone is a mechanosensitive organ that is also a common metastatic site for prostate cancer. However, the mechanism by which the tumor interacts with the bone microenvironment to further promote disease progression remains to be fully understood.
Externí odkaz:
https://doaj.org/article/40d117a112a846d7a95c8e528cfd79d6
Autor:
Hongwei Guo, Hua Luo, Hebao Yuan, Yudui Xia, Pan Shu, Xin Huang, Yi Lu, Xia Liu, Evan T. Keller, Duxin Sun, Jiagang Deng, Jian Zhang
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-3 (2021)
Externí odkaz:
https://doaj.org/article/b75bc552099d4df58ac7568a960887f8
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Differential expression (DE) and gene set enrichment (GSE) analysis tend to be carried out separately. Here, the authors present iDEA (integrative Differential expression and gene set Enrichment Analysis) for the analysis of scRNAseq data which uses
Externí odkaz:
https://doaj.org/article/19d63e4d079b409da993da1c785284aa
Autor:
Veronica Mendoza-Reinoso, Patricia M. Schnepp, Dah Youn Baek, John R. Rubin, Ernestina Schipani, Evan T. Keller, Laurie K. McCauley, Hernan Roca
Publikováno v:
Cells, Vol 11, Iss 23, p 3712 (2022)
The clearance of apoptotic cancer cells by macrophages, known as efferocytosis, fuels the bone-metastatic growth of prostate cancer cells via pro-inflammatory and immunosuppressive processes. However, the exact molecular mechanisms remain unclear. In
Externí odkaz:
https://doaj.org/article/5b0d4efb334b440bb74d6091d6258d3b
Autor:
Mayara Garcia de Mattos Barbosa, Hui Liu, Daniel Huynh, Greg Shelley, Evan T. Keller, Brian T. Emmer, Emily Sherman, David Ginsburg, Andrew A. Kennedy, Andrew W. Tai, Christiane Wobus, Carmen Mirabeli, Thomas M. Lanigan, Milagros Samaniego, Wenzhao Meng, Aaron M. Rosenfeld, Eline T. Luning Prak, Jeffrey L. Platt, Marilia Cascalho
Publikováno v:
JCI Insight, Vol 6, Iss 9 (2021)
Abs that neutralize SARS-CoV-2 are thought to provide the most immediate and effective treatment for those severely afflicted by this virus. Because coronavirus potentially diversifies by mutation, broadly neutralizing Abs are especially sought. Here
Externí odkaz:
https://doaj.org/article/198aea9cddb24432ade981042f42b068
Autor:
Brittany Rupp, Sarah Owen, Harrison Ball, Kaylee Judith Smith, Valerie Gunchick, Evan T. Keller, Vaibhav Sahai, Sunitha Nagrath
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 14, p 7852 (2022)
As pancreatic cancer is the third deadliest cancer in the U.S., the ability to study genetic alterations is necessary to provide further insight into potentially targetable regions for cancer treatment. Circulating tumor cells (CTCs) represent an esp
Externí odkaz:
https://doaj.org/article/d36747c4a4474359a5a1b0a2ce51c5d9