Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Evan T Geller"'
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 3, Iss C (2014)
In Alzheimer's disease, progressive supranuclear palsy, and a number of other neurodegenerative diseases, the microtubule associated protein tau aggregates to form intracellular neurofibrillary tangles and glial tangles, abnormal structures that are
Externí odkaz:
https://doaj.org/article/aa36e6528cdf411b9dd2677739b0c699
Autor:
Steven K. Reilly, Acadia A. Kocher, Severin Uebbing, James P. Noonan, Justin Cotney, Neeru Gandotra, Jake Gockley, Curt Scharfe, Evan T. Geller
Publikováno v:
Proceedings of the National Academy of Sciences. 118
Genetic changes that altered the function of gene regulatory elements have been implicated in the evolution of human traits such as the expansion of the cerebral cortex. However, identifying the particular changes that modified regulatory activity du
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a017f4c8b8a87f4150a22a49e6ed394e
https://doi.org/10.1073/pnas.2007049118
https://doi.org/10.1073/pnas.2007049118
Autor:
Xinyi Guo, Alejandro Méndez-Mancilla, Neville E. Sanjana, Hans-Hermann Wessels, Moss Ng, Peter Smibert, Antonino Montalbano, Evan T. Geller, Noa Liscovitch-Brauer, Kung C, Suma Jaini, Jiehui Deng, Akash Sookdeo
Pooled CRISPR screens have been used to identify genes responsible for specific phenotypes and diseases, and, more recently, to connect genetic perturbations with multi-dimensional gene expression profiles. Here, we describe a method to link genome-w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37b59cf2517f5316dfb8602a3c47df76
https://doi.org/10.1101/2020.11.20.390971
https://doi.org/10.1101/2020.11.20.390971
Autor:
Jake Gockley, James P. Noonan, Severin Uebbing, Neeru Gandotra, Curt Scharfe, Acadia A. Kocher, Evan T. Geller, Steven K. Reilly, Justin Cotney
Genetic changes that altered the function of gene regulatory elements have been implicated in the evolution of the human brain. However, identifying the particular changes that modified regulatory activity during neurodevelopment remains challenging.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c42ced4ccaf321944208f67935398a2a
https://doi.org/10.1101/865519
https://doi.org/10.1101/865519
Changes in gene regulation have been linked to the expansion of the human cerebral cortex and to neurodevelopmental disorders. However, the biological effects of genetic variation within developmental regulatory elements on human corticogenesis are n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f58e4b790a7890fcab76fc603e7d33dd
https://doi.org/10.1101/852673
https://doi.org/10.1101/852673
Autor:
Yue Mei, Evan T. Geller, Martina Krenzer, A. Ercument Cicek, Yan Wang, Jinyu Wu, Kun Xia, Zhongshan Li, Rebecca A. Muhle, Xin He, Zhong Sheng Sun, James P. Noonan, Yuwen Liu, Siming Zhao, Jean Morrison, Yanyu Liang, Jinchen Li, Yi Jiang, Nicholas W. Knoblauch, Iuliana Ionita-Laza
Publikováno v:
American Journal of Human Genetics
Analysis of de novo mutations (DNMs) from sequencing data of nuclear families has identified risk genes for many complex diseases, including multiple neurodevelopmental and psychiatric disorders. Most of these efforts have focused on mutations in pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff6eefddf4d77cc38f59808f42bba81c
https://doi.org/10.1016/j.ajhg.2018.03.023
https://doi.org/10.1016/j.ajhg.2018.03.023
Autor:
Antonino Montalbano, Xinyi Guo, Peter Smibert, Hans-Hermann Wessels, Akash Sookdeo, Neville E. Sanjana, Chia-Yu Kung, Nicholas G Moss, Noa Liscovitch-Brauer, Alejandro Méndez-Mancilla, Suma Jaini, Evan T. Geller, Jiale Deng
Publikováno v:
Nat Biotechnol
CRISPR screens have been used to connect genetic perturbations with changes in gene expression and phenotypes. Here we describe a CRISPR-based, single-cell combinatorial indexing assay for transposase-accessible chromatin (CRISPR–sciATAC) to link g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dfa66b7bdc6f93cbac7e3ae15066685
https://pubmed.ncbi.nlm.nih.gov/33927415
https://pubmed.ncbi.nlm.nih.gov/33927415
Autor:
Lu Lu, Mateusz Legut, Oded Danziger, Hemali Phatnani, Brad R. Rosenberg, Neville E. Sanjana, Silas Maniatis, Evan T. Geller, Tristan X. Jordan, Silva Kasela, Zharko Daniloski, Tuuli Lappalainen, Eleni P. Mimitou, Benjamin R. tenOever, Hans-Hermann Wessels, Peter Smibert, Daisy A. Hoagland
Publikováno v:
The Journal of Infection
Cell
Cell
To better understand host-virus genetic dependencies and find potential therapeutic targets for COVID-19, we performed a genome-scale CRISPR loss-of-function screen to identify host factors required for SARS-CoV-2 viral infection of human alveolar ep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bc3cf98dcb9c9d9b4e78d1b7a55c8c4
https://doi.org/10.1016/j.cell.2020.10.030
https://doi.org/10.1016/j.cell.2020.10.030
Autor:
Christine Stevens, Michael E. Zwick, Deepthi Rajagopalan, Mara Parellada, David J. Cutler, Li-San Wang, Norio Ozaki, Jinlu Cai, Lauren A. Weiss, Patricia Jiménez González, Jeffrey C. Barrett, Silvia De Rubeis, Helena Kilpinen, Alexander Kolevzon, Timothy W. Yu, Michael John Owen, Geraldine Dawson, Martin Schulte-Rüther, Jeremy R. Parr, Aarno Palotie, Eftichia Duketis, Lambertus Klei, Irene Lee, Bridget A. Fernandez, Aniko Sabo, Matthew W. State, Sarah Curran, Lucy Crooks, Chad M. Schafer, Avi Ma'ayan, Stephen Sanders, Evan T. Geller, Monica Biscaldi, Stephen W. Scherer, Christopher S. Poultney, Mark J. Daly, Patrick Bolton, Kaija Puura, Maria H. Chahrour, Michael Gill, Li Liu, Louise Gallagher, Ryan K. C. Yuen, Jack A. Kosmicki, Abraham Reichenberg, Christine M. Freitag, Shaun Purcell, Andreas G. Chiocchetti, Peter Szatmari, Sabine M. Klauck, Shih-Chen Fu, Christian R. Marshall, Joseph D. Buxbaum, Tarjinder Singh, Bernie Devlin, Chiao-Feng Lin, A. Ercument Cicek, Karola Rehnström, Pamela Sklar, Otto Valladares, Michael Sachse, Terho Lehtimäki, R. Sean Hill, Arthur P. Goldberg, A. Jeremy Willsey, Jing Lei, Branko Aleksic, Menachem Fromer, Yan Kou, Jessica M. Brownfeld, Annette Voran, Kathryn Roeder, Gerard D. Schellenberg, David Skuse, Thomas Lehner, Hilary Coon, Benjamin M. Neale, Iuliana Ionita-Laza, Kristiina Tammimies, Stephen J. Guter, Christopher A. Walsh, James S. Sutcliffe, Xin-Xin He, Alison L. McInnes, Emily L. Crawford, Nicholas G. Campbell, Angel Carracedo, R. Susan Walker, Edwin H. Cook, Kaitlin E. Samocha, Christina M. Hultman
Publikováno v:
Nature
The genetic architecture of autism spectrum disorder involves the interplay of common and rare variants and their impact on hundreds of genes. Using exome sequencing, here we show that analysis of rare coding variation in 3,871 autism cases and 9,937
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2af40051d43c8fefc19ce3594f553e4f
http://europepmc.org/articles/PMC4402723
http://europepmc.org/articles/PMC4402723
Autor:
Omar Jabado, Menachem Fromer, Chad M. Schafer, Braden E. Boone, Jack R. Wimbish, Benjamin M. Neale, Guiqing Cai, Kathryn Roeder, Gerard D. Schellenberg, Li-San Wang, Christine Stevens, Avi Ma'ayan, Bernie Devlin, Richard A. Gibbs, Zuleyma Peralta, Shawn Levy, Yan Kou, Yi Han, Eric Boerwinkle, Evan T. Geller, Kiran V. Garimella, Emily L. Crawford, Jeffrey G. Reid, Chiao-Feng Lin, Elizabeth J. Rossin, Timothy Fennell, Tuo Zhao, Jared Maguire, Mark A. DePristo, Eric Banks, Mark J. Daly, Irene Newsham, Edwin H. Cook, Paz Polak, Ryan Poplin, Kaitlin E. Samocha, Vladimir Makarov, Khalid Shakir, Han Liu, Yuanqing Wu, Benjamin F. Voight, James S. Sutcliffe, Donna M. Muzny, Shamil R. Sunyaev, Li Liu, Andrew Kirby, Seungtai Yoon, Joseph D. Buxbaum, Uma Nagaswamy, Ruth Dannenfelser, Stacey Gabriel, Aniko Sabo, Jayon Lihm, Lora Lewis, Elaine T. Lim, Jason Flannick, Nicholas G. Campbell, Otto Valladares, Catalina Betancur
Publikováno v:
Nature
Nature, 2012, 485 (7397), pp.242-5. ⟨10.1038/nature11011⟩
Nature, Nature Publishing Group, 2012, 485 (7397), pp.242-5. ⟨10.1038/nature11011⟩
Nature, 2012, 485 (7397), pp.242-5. ⟨10.1038/nature11011⟩
Nature, Nature Publishing Group, 2012, 485 (7397), pp.242-5. ⟨10.1038/nature11011⟩
International audience; Autism spectrum disorders (ASD) are believed to have genetic and environmental origins, yet in only a modest fraction of individuals can specific causes be identified. To identify further genetic risk factors, here we assess t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06b98c68c6e4b51166d7a1f7dc556ec4
https://doi.org/10.1038/nature11011
https://doi.org/10.1038/nature11011