Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Evan R. Prather"'
Autor:
Gregory J. Eisinger, MD, MSSW, Wissam Osman, BS, Evan R. Prather, BS, Mark W. Julian, MS, Mikhail A. Gavrilin, PhD, Elliott D. Crouser, MD, Mark D. Wewers, MD
Publikováno v:
Critical Care Explorations, Vol 4, Iss 2, p e0631 (2022)
OBJECTIVES:. Increased monocyte distribution width (MDW) has recently been shown to be a reliable indicator of early sepsis detection. This study therefore sought to determine if inflammasome activation can be linked to monocyte size changes in sepsi
Externí odkaz:
https://doaj.org/article/580ea3e2caa841c598066c52471edd94
Autor:
Mikhail A. Gavrilin, Christian C. McAndrew, Evan R. Prather, MuChun Tsai, Carleen R. Spitzer, Min-Ae Song, Srabani Mitra, Anasuya Sarkar, Peter G. Shields, Philip T. Diaz, Mark D. Wewers
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Rationale: Caspase-1 is a zymogen whose activation predominantly depends upon the assembly of ASC monomers into insoluble prion-like polymers (specks). ASC polymers support caspase-1 dimer formation inducing a proximity mediated auto-activation of ca
Externí odkaz:
https://doaj.org/article/1d59a9fb897c418a97241b94182ae790
Publikováno v:
The Journal of biological chemistry. 298(6)
Apoptosis-associated speck-like protein containing a caspase recruitment domain (CARD) (ASC) is a 22 kDa protein that functions as the central adaptor for inflammasome assembly. ASC forms insoluble specks in monocytes undergoing pyroptosis, and the p
Publikováno v:
J Immunol
Inflammasome activation is regulated in part by the posttranslational modification of inflammasome proteins. Tyrosine phosphorylation is one possible modification. Having previously shown that the protein tyrosine kinase (PTK) inhibitor AG126 greatly
Publikováno v:
D70. REVISITING LUNG INFECTION AND INFLAMMATORY AXES.
Autor:
Evan R. Prather, Gregory Eisinger, Elliott D. Crouser, Mark D. Wewers, Wissam Osman, Mikhail A. Gavrilin
Publikováno v:
Chest. 160:A1083
TOPIC: Critical Care TYPE: Original Investigations PURPOSE: Gasdermin-D (GSDMD) is a pore-forming molecule that serves as the final effector of pyroptosis (a form of inflammatory cell death) following activation of the cellular inflammasome in monocy
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 19, Iss 2, p 417 (2018)
International Journal of Molecular Sciences, Vol 19, Iss 2, p 417 (2018)
Ischemia reperfusion (IR), present in myocardial infarction or extremity injuries, is a major clinical issue and leads to substantial tissue damage. Molecular mechanisms underlying IR injury in striated muscles involve the production of reactive oxyg