Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Evan R. Delgado"'
Autor:
Brandon M. Lehrich, Evan R. Delgado
Publikováno v:
Organogenesis, Vol 20, Iss 1 (2024)
ABSTRACTHepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality globally. HCC is highly heterogenous with diverse etiologies leading to different driver mutations potentiating unique tumor immune microenvironments. Cur
Externí odkaz:
https://doaj.org/article/0bb3b8e20a174a56bb705d9ae5314791
Autor:
Jihong Ma, Xinping Tan, Yongkook Kwon, Evan R. Delgado, Arman Zarnegar, Marie C. DeFrances, Andrew W. Duncan, Reza Zarnegar
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 565-582 (2022)
Background & Aims: Nonalcoholic fatty liver disease is a frequent cause of hepatic dysfunction and is now a global epidemic. This ailment can progress to an advanced form called nonalcoholic steatohepatitis (NASH) and end-stage liver disease. Current
Externí odkaz:
https://doaj.org/article/7e58c9b02e0346ed9b58c9790204be6a
Autor:
Kazuki Takeishi, Alexandra Collin de l’Hortet, Yang Wang, Kan Handa, Jorge Guzman-Lepe, Kentaro Matsubara, Kazutoyo Morita, Sae Jang, Nils Haep, Rodrigo M. Florentino, Fangchao Yuan, Ken Fukumitsu, Kimimasa Tobita, Wendell Sun, Jonathan Franks, Evan R. Delgado, Erik M. Shapiro, Nicolas A. Fraunhoffer, Andrew W. Duncan, Hiroshi Yagi, Tomoji Mashimo, Ira J. Fox, Alejandro Soto-Gutierrez
Publikováno v:
Cell Reports, Vol 31, Iss 9, Pp - (2020)
Summary: The availability of an autologous transplantable auxiliary liver would dramatically affect the treatment of liver disease. Assembly and function in vivo of a bioengineered human liver derived from induced pluripotent stem cells (iPSCs) has n
Externí odkaz:
https://doaj.org/article/2669d2ed58534d89a4a0eccc2bf0473f
Autor:
Evan R. Delgado, Junyan Tao, Aaron W. Bell, Shikai Hu, Minakshi Poddar, Sucha Singh, Satdarshan P. Monga
Publikováno v:
The FASEB Journal. 36
Autor:
Evan R. Delgado, Junyan Tao, Aaron W. Bell, Jackson McGaughey, Jai Ganesh, Minakshi Poddar, Sucha Singh, Satdarshan P. Monga
Publikováno v:
The FASEB Journal. 36
Autor:
Nairita Roy, Frances Alencastro, Bayley A. Roseman, Sierra R. Wilson, Evan R. Delgado, Meredith C. May, Bharat Bhushan, Fiona M. Bello, Michael J. Jurczak, Sruti Shiva, Joseph Locker, Sebastien Gingras, Andrew W. Duncan
Publikováno v:
The American journal of pathology. 192(9)
Nonalcoholic fatty liver disease (NAFLD) is an epidemic affecting 30% of the US population. It is characterized by insulin resistance, and by defective lipid metabolism and mitochondrial dysfunction in the liver. SLC25A34 is a major repressive target
Autor:
Bryan N. Brown, Frances Alencastro, Samuel T. LoPresti, Nairita Roy, Satdarshan P.S. Monga, Andrew W. Duncan, Elizabeth C. Stahl, Patrick D. Wilkinson, Evan R. Delgado, Clint D. Skillen, Martin J. Haschak
Publikováno v:
Am J Pathol
Aging is associated with inflammation and metabolic syndrome, which manifests in the liver as nonalcoholic fatty liver disease (NAFLD). NAFLD can range in severity from steatosis to fibrotic steatohepatitis and is a major cause of hepatic morbidity.
Publikováno v:
The Liver
Autor:
Madeleine P. Leek, Nairita Roy, Frances Alencastro, Evan R. Delgado, Kerollos Kamel, Andrew P. Duncan, Patrick D. Wilkinson
Publikováno v:
The FASEB Journal. 35
Autor:
Matthew P. Weirich, Elizabeth C. Stahl, Madeleine P. Leek, Frances Alencastro, Evan R. Delgado, Whitney K. Brown, P. Anthony Otero, Nairita Roy, Maelee I. Chen, Patrick D. Wilkinson, Andrew W. Duncan
Publikováno v:
Hepatology. 69:1242-1258
The liver contains a mixture of hepatocytes with diploid or polyploid (tetraploid, octaploid, etc.) nuclear content. Polyploid hepatocytes are commonly found in adult mammals, representing ~90% of the entire hepatic pool in rodents. The cellular and