Zobrazeno 1 - 10
of 298
pro vyhledávání: '"Evan R Williams"'
Autor:
Deepti Karandur, Moitrayee Bhattacharyya, Zijie Xia, Young Kwang Lee, Serena Muratcioglu, Darren McAffee, Ethan D McSpadden, Baiyu Qiu, Jay T Groves, Evan R Williams, John Kuriyan
Publikováno v:
eLife, Vol 9 (2020)
Ca2+/calmodulin-dependent protein kinase II (CaMKII) is an oligomeric enzyme with crucial roles in neuronal signaling and cardiac function. Previously, we showed that activation of CaMKII triggers the exchange of subunits between holoenzymes, potenti
Externí odkaz:
https://doaj.org/article/811a46346e94491a8a20e6b13f51505a
Autor:
Moitrayee Bhattacharyya, Margaret M Stratton, Catherine C Going, Ethan D McSpadden, Yongjian Huang, Anna C Susa, Anna Elleman, Yumeng Melody Cao, Nishant Pappireddi, Pawel Burkhardt, Christine L Gee, Tiago Barros, Howard Schulman, Evan R Williams, John Kuriyan
Publikováno v:
eLife, Vol 5 (2016)
Activation triggers the exchange of subunits in Ca2+/calmodulin-dependent protein kinase II (CaMKII), an oligomeric enzyme that is critical for learning, memory, and cardiac function. The mechanism by which subunit exchange occurs remains elusive. We
Externí odkaz:
https://doaj.org/article/495a7e27d1bf4339b6867892a9602ba0
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e13888 (2010)
BackgroundAnthrax toxin is comprised of protective antigen (PA), lethal factor (LF), and edema factor (EF). These proteins are individually nontoxic; however, when PA assembles with LF and EF, it produces lethal toxin and edema toxin, respectively. A
Externí odkaz:
https://doaj.org/article/8dab94c52e83412e99432771e35e4d1d
Publikováno v:
ACS Central Science, Vol 9, Iss 8, Pp 1611-1622 (2023)
Externí odkaz:
https://doaj.org/article/ac7d9d7ee83c436d9bcd1873a4f47d93
Autor:
Conner C. Harper, Zachary M. Miller, Matthew S. McPartlan, Jacob S. Jordan, Randall E. Pedder, Evan R. Williams
Publikováno v:
ACS Nano. 17:7765-7774
Autor:
Casey J. Chen, Evan R. Williams
Publikováno v:
Chemical science, vol 14, iss 18
Accelerated reactions in microdroplets have been reported for a wide range of reactions with some microdroplet reactions occurring over a million times faster than the same reaction in bulk solution. Unique chemistry at the air-water interface has be
Publikováno v:
Journal of the American Chemical Society. 144:23368-23378
The tobacco mosaic viral capsid protein (TMV) is a frequent target for derivatization for myriad applications, including drug delivery, biosensing, and light harvesting. However, solutions of the stacked disk assembly state of TMV are difficult to ch
Laser Heating Nanoelectrospray Emitters for Fast Protein Melting Measurements with Mass Spectrometry
Autor:
Jacob S. Jordan, Evan R. Williams
Publikováno v:
Analytical Chemistry. 94:16894-16900
Temperature-controlled nanoelectrospray ionization has been used to measure heat-induced conformational changes of biomolecules by mass spectrometry, but long thermal equilibration times associated with heating or cooling an entire emitter limit how
Publikováno v:
Nature Reviews Methods Primers. 3
Autor:
Zachary M. Miller, Conner C. Harper, Hyuncheol Lee, Amanda J. Bischoff, Matthew B. Francis, David V. Schaffer, Evan R. Williams
Publikováno v:
Journal of the American Society for Mass Spectrometry. 33(11)
Short-time Fourier transforms with short segment lengths are typically used to analyze single ion charge detection mass spectrometry (CDMS) data either to overcome effects of frequency shifts that may occur during the trapping period or to more preci