Zobrazeno 1 - 10
of 475
pro vyhledávání: '"Evan R Simpson"'
Autor:
Michelle L Van Sinderen, Gregory R Steinberg, Sebastian B Jørgensen, Jane Honeyman, Jenny D Chow, Kerrie A Herridge, Amy L Winship, Evdokia Dimitriadis, Margaret E E Jones, Evan R Simpson, Wah Chin Boon
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0136143 (2015)
The maintenance of glucose homeostasis within the body is crucial for constant and precise performance of energy balance and is sustained by a number of peripheral organs. Estrogens are known to play a role in the maintenance of glucose homeostasis.
Externí odkaz:
https://doaj.org/article/553c991278d747b2b5f9f923ad908507
Autor:
Michelle L Van Sinderen, Gregory R Steinberg, Sebastian B Jørgensen, Sarah Q To, Kevin C Knower, Colin D Clyne, Jane Honeyman, Jenny D Chow, Kerrie A Herridge, Margaret E E Jones, Evan R Simpson, Wah Chin Boon
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e87230 (2014)
Estrogens are known to play a role in modulating metabolic processes within the body. The Aromatase knockout (ArKO) mice have been shown to harbor factors of Metabolic syndrome with central adiposity, hyperinsulinemia and male-specific hepatic steato
Externí odkaz:
https://doaj.org/article/23c50909e3f348f3a1f35cec7dfbaf44
Autor:
Nicholas I Fleming, Kevin C Knower, Kyren A Lazarus, Peter J Fuller, Evan R Simpson, Colin D Clyne
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e14389 (2010)
BackgroundGranulosa cell tumors (GCT) of the ovary often express aromatase and synthesize estrogen, which in turn may influence their progression. Recently a specific point mutation (C134W) in the FOXL2 protein was identified in >94% of adult-type GC
Externí odkaz:
https://doaj.org/article/c82a16fd93a54a4082e574ae1d0e46f4
Autor:
Evan R. Simpson, Gregory R. Steinberg, Jonathan S. Oakhill, Nicole I. Hunger, Kerry J. McInnes, Kristy A. Brown
Supplementary Figure 1 from Subcellular Localization of Cyclic AMP-Responsive Element Binding Protein-Regulated Transcription Coactivator 2 Provides a Link between Obesity and Breast Cancer in Postmenopausal Women
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1569e434849d32622f6047e88734630a
https://doi.org/10.1158/0008-5472.22378437.v1
https://doi.org/10.1158/0008-5472.22378437.v1
Autor:
Kenneth S. Korach, Kara L. Britt, Joanne S. Morris, Genevieve V. Dall, Evan R. Simpson, Yukitomo Arao, Katherine J. Hamilton, Elaine Dzierzak, Gail P. Risbridger, Torsten Stein, Sylvia C. Hewitt, Robert G. Ramsay, Wah Chin Boon, Jessica L. Vieusseux, Robin L. Anderson
Publikováno v:
Stem Cell Reports, Vol 8, Iss 2, Pp 417-431 (2017)
Stem Cell Reports
Dall, G V, Vieusseux, J L, Korach, K S, Arao, Y, Hewitt, S C, Hamilton, K J, Dzierzak, E, Boon, W C, Simpson, E R, Ramsay, R G, Stein, T, Morris, J S, Anderson, R L, Risbridger, G P & Britt, K L 2017, ' SCA-1 Labels a Subset of Estrogen-Responsive Bipotential Repopulating Cells within the CD24(+) CD49f(hi) Mammary Stem Cell-Enriched Compartment ', Stem Cell Reports, vol. 8, no. 2, pp. 417-431 . https://doi.org/10.1016/j.stemcr.2016.12.022
Stem Cell Reports
Dall, G V, Vieusseux, J L, Korach, K S, Arao, Y, Hewitt, S C, Hamilton, K J, Dzierzak, E, Boon, W C, Simpson, E R, Ramsay, R G, Stein, T, Morris, J S, Anderson, R L, Risbridger, G P & Britt, K L 2017, ' SCA-1 Labels a Subset of Estrogen-Responsive Bipotential Repopulating Cells within the CD24(+) CD49f(hi) Mammary Stem Cell-Enriched Compartment ', Stem Cell Reports, vol. 8, no. 2, pp. 417-431 . https://doi.org/10.1016/j.stemcr.2016.12.022
Summary Estrogen stimulates breast development during puberty and mammary tumors in adulthood through estrogen receptor-α (ERα). These effects are proposed to occur via ERα+ luminal cells and not the mammary stem cells (MaSCs) that are ERαneg. Si
Publikováno v:
Current Opinion in Pharmacology. 31:90-96
Obesity is associated with an increased risk of estrogen-dependent breast cancer after menopause. Adipose tissue undergoes important changes in obesity due to excess storage of lipids, leading to adipocyte cell death and the recruitment of macrophage
Publikováno v:
Comprehensive Physiology
As adipose tissue depots are active endocrine organs, they secrete a variety of hormones (including estrogens from white adipose) and inflammatory mediators, which have important implications in numerous obesity-associated diseases. Adipose tissues a
Publikováno v:
Life Sciences. 158:130-136
Controversy surrounds the gender basis of progression in chronic kidney disease. Unfortunately, most experimental studies addressing this question do not distinguish between direct effects of estrogen and indirect activation of estrogen receptors thr
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 145:179-186
Aromatase is the critical enzyme that converts androgens to estrogens. It is frequently highly expressed in the tumour bearing breast of women diagnosed with estrogen receptor positive tumours, resulting in dramatically increased local estrogen produ
Autor:
Sean M. Grimmond, Christine L. Clarke, Aaron G. Smith, Peter J. Leedman, John W. Funder, Joel M. Goode, Peter Bailey, Wayne D. Tilley, Peter J. Fuller, George E.O. Muscat, Dennis H. Dowhan, Natalie A. Eriksson, Tae Gyu Oh, Evan R. Simpson, Eloise Dray
Publikováno v:
Molecular Endocrinology. 28:1166-1185
Protein arginine methyltransferases (PRMTs) methylate arginine residues on histones and target transcription factors that play critical roles in many cellular processes, including gene transcription, mRNA splicing, proliferation, and differentiation.