Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Evan P. Hass"'
Autor:
Dilara O. Halim, Gopinath Krishnan, Evan P. Hass, Soojin Lee, Mamta Verma, Sandra Almeida, Yuanzheng Gu, Deborah Y. Kwon, Thomas G. Fazzio, Fen-Biao Gao
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114375- (2024)
Summary: GGGGCC (G4C2) repeat expansion in C9ORF72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). How this genetic mutation leads to neurodegeneration remains largely unknown. Using CRISPR-C
Externí odkaz:
https://doaj.org/article/db2eea12f92c422ea5615950ffbf79b1
Autor:
Gabrijela Dumbović, Ulrich Braunschweig, Heera K. Langner, Michael Smallegan, Josep Biayna, Evan P. Hass, Katarzyna Jastrzebska, Benjamin Blencowe, Thomas R. Cech, Marvin H. Caruthers, John L. Rinn
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
RNA localization plays an important role in transcriptome regulation. The majority of TERT transcripts are detected in the nucleus and TUG1 lncRNAs in both the nucleus and cytoplasm. Here, the authors combine single-cell RNA imaging, antisense oligon
Externí odkaz:
https://doaj.org/article/0a69eec1edfb49478cd0ef2274c07334
Autor:
Gabrijela Dumbović, Ulrich Braunschweig, Heera K. Langner, Michael Smallegan, Josep Biayna, Evan P. Hass, Katarzyna Jastrzebska, Benjamin Blencowe, Thomas R. Cech, Marvin H. Caruthers, John L. Rinn
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/f1914cc10d7442a8ae60fc72d2d25477
Autor:
Evan P. Hass, David C. Zappulla
Publikováno v:
Non-Coding RNA, Vol 6, Iss 1, p 9 (2020)
Telomerase RNA contains a template for synthesizing telomeric DNA and has been proposed to act as a flexible scaffold for holoenzyme protein subunits in the RNP. In Saccharomyces cerevisiae, the telomerase RNA, TLC1, is bound by the Sm7 protein compl
Externí odkaz:
https://doaj.org/article/57c126385ee744e4b3f53dcb35f38be1
Autor:
Evan P. Hass, Yu Hsuan Lee, Will Campodonico, Yong Kyu Lee, Erika Lasda, Jaynish S Shah, John L. Rinn, Taeyoung Hwang
Many of the biological functions performed by RNA are mediated by RNA-binding proteins (RBPs), and understanding the molecular basis of these interactions is fundamental to molecular biology. Here, we present MPRNA-immunoprecipitation (MPRNA-IP), an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fb425a53f4226a75d0ea946f5854520
https://doi.org/10.1101/2022.06.13.495920
https://doi.org/10.1101/2022.06.13.495920
Autor:
Robert T. Jones, Evan P. Hass, Qiong Zhou, Sébastien Rinaldetti, Simon R.V. Knott, Thomas R. Cech, Molishree Joshi, Dan Theodorescu, Bassem Ben Cheikh, Neeraj Agarwal, Daniel V. LaBarbera
Publikováno v:
Proceedings of the National Academy of Sciences. 118
Bladder cancer (BC) has a 70% telomerase reverse transcriptase (TERT or hTERT in humans) promoter mutation prevalence, commonly at -124 base pairs, and this is associated with increased hTERT expression and poor patient prognosis. We inserted a green
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3396dcea9bbc6d34ec3fc3d140be2fd
https://doi.org/10.1073/pnas.2102423118
https://doi.org/10.1073/pnas.2102423118
Autor:
John L. Rinn, Evan P. Hass, Marvin H. Caruthers, Katarzyna Jastrzebska, Josep Biayna, Ulrich Braunschweig, Heera K. Langner, Gabrijela Dumbovic, Benjamin J. Blencowe, Michael J. Smallegan, Thomas R. Cech
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
The spatial partitioning of the transcriptome in the cell is an important form of gene-expression regulation. Here, we address how intron retention influences the spatio-temporal dynamics of transcripts from two clinically relevant genes: TERT (Telom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf5077cf0354d59af55e2f2076738a02
http://europepmc.org/articles/PMC8175569
http://europepmc.org/articles/PMC8175569
Publikováno v:
Proceedings of the National Academy of Sciences. 116:18488-18497
Telomerase is pathologically reactivated in most human cancers, where it maintains chromosomal telomeres and allows immortalization. Because telomerase reverse transcriptase (TERT) is usually the limiting component for telomerase activation, numerous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::921e1428e7780e62308e07f1fd237203
https://doi.org/10.1073/pnas.1908275116
https://doi.org/10.1073/pnas.1908275116
Publikováno v:
Molecular and Cellular Biology
The telomerase ribonucleoprotein (RNP) counters the chromosome end replication problem, completing genome replication to prevent cellular senescence in yeast, humans, and most other eukaryotes. The telomerase RNP core enzyme is composed of a dedicate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45ab6f726b30f4f926d8dcc11a5caeb2
http://europepmc.org/articles/PMC7685517
http://europepmc.org/articles/PMC7685517
The telomerase RNP counters the chromosome end-replication problem, completing genome replication to prevent cellular senescence in yeast, humans, and most other eukaryotes. The telomerase RNP core enzyme is composed of a dedicated RNA subunit and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a36c9a34d4eeef5f861d2972b3e9c76