Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Evan P. Booy"'
Publikováno v:
Molecular Cancer, Vol 16, Iss 1, Pp 1-15 (2017)
Abstract Background BC200 is a long non-coding RNA expressed at high levels in the brain and elevated in a variety of tumour types. BC200 has a hypothesized role in translational regulation; however, to date the functional role of BC200 in both norma
Externí odkaz:
https://doaj.org/article/7a7cbcd039994e14ab8c40714a9daae5
Publikováno v:
Journal of Nucleic Acids, Vol 2017 (2017)
Guanine quadruplexes (G4s) are four-stranded secondary structures of nucleic acids which are stabilized by noncanonical hydrogen bonding systems between the nitrogenous bases as well as extensive base stacking, or pi-pi, interactions. Formation of th
Externí odkaz:
https://doaj.org/article/662a9fbabf7b4efc8bedde280078f228
Publikováno v:
RNA. :rna.079649.123
The SRP9/SRP14 heterodimer is a central component of signal recognition particle (SRP) RNA (7SL) processing and Alu retrotransposition. In this study, we sought to establish the role of nuclear SRP9/SRP14 in the transcriptional regulation of 7SL and
Publikováno v:
Biochemistry and Cell Biology. 98:70-82
Human 2′–5′ oligoadenylate synthetases (OAS) are a family of interferon-inducible proteins that, upon activation by double-stranded RNA, polymerize ATP into 2′–5′ linked oligoadenylates. In this study, we probed the RNA cofactor specifici
Publikováno v:
The Journal of Biological Chemistry
BC200 is a noncoding RNA elevated in a broad spectrum of tumor cells that is critical for cell viability, invasion, and migration. Overexpression studies have implicated BC200 and the rodent analog BC1 as negative regulators of translation in both ce
Autor:
Evan P. Booy, Taegi Choi, Daniel Gussakovsky, Ewan K.S. McRae, Sean A. McKenna, Peyman Ezzati
Publikováno v:
Nucleic Acids Research
BC200 is a long non-coding RNA primarily expressed in brain but aberrantly expressed in various cancers. To gain a further understanding of the function of BC200, we performed proteomic analyses of the BC200 ribonucleoprotein (RNP) by transfection of
Autor:
Jörg Stetefeld, Trushar R. Patel, Sean A. McKenna, Markus Meier, Natalie Krahn, Evan P. Booy, Darren L. Gemmill, Amit Koul, Nikhat Lubna
Publikováno v:
Biophysical Journal
Oligoadenylate synthetases (OASs) are a family of interferon-inducible enzymes that require double-stranded RNA (dsRNA) as a cofactor. Upon binding dsRNA, OAS undergoes a conformational change and is activated to polymerize ATP into 2′-5′-oligoad
Autor:
Ewan K.S. McRae, Natalie Krahn, Kevin McEleney, Aniel Moya-Torres, George L. Orriss, Jörg Stetefeld, Trushar R. Patel, Matthew McDougall, Markus Meier, Evan P. Booy, Sean A. McKenna
Publikováno v:
Nucleic Acids Research
The identification of four-stranded G-quadruplexes (G4s) has highlighted the fact that DNA has additional spatial organisations at its disposal other than double-stranded helices. Recently, it became clear that the formation of G4s is not limited to
Publikováno v:
RNA. 22:1884-1892
The effective tracking and purification of biological RNAs and RNA protein complexes is currently challenging. One promising strategy to simultaneously address both of these problems is to develop high-affinity RNA aptamers against taggable small mol
Autor:
Steven J. Dupas, Ewan K.S. McRae, Evan P. Booy, Richard P. Fahlman, Sean A. McKenna, Ramanaguru Siva Piragasam
Publikováno v:
RNA
DDX21 is a newly discovered RNA G-quadruplex (rG4) binding protein with no known biological rG4 targets. In this study we identified 26 proteins that are expressed at significantly different levels in cells expressing wild type DDX21 relative to an r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dc3d4139cb1d05585fd3ca156433a5e
https://doi.org/10.1101/588798
https://doi.org/10.1101/588798