Enduring Reversal of Neuropathic Pain by a Single Intrathecal Injection of Adenosine 2A Receptor Agonists: A Novel Therapy for Neuropathic Pain

Autor: Jacqueline A. Harrison, Erin D. Milligan, Evan M. Sloane, Stephen Poole, Lisa C. Loram, Steven F. Maier, Debra Berkelhammer, Frederick R. Taylor, Jayson M. Rieger, Paige W. Sholar, Linda R. Watkins, Mark R. Hutchinson, Benjamen D. Coats

Publikováno v: The Journal of Neuroscience. 29:14015-14025

Previous studies of peripheral immune cells have documented that activation of adenosine 2A receptors (A2ARs) decrease proinflammatory cytokine release and increase release of the potent anti-inflammatory cytokine, interleukin-10 (IL-10). Given the g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaaec69667d9b8e99c176fe5b0ac5a55
https://doi.org/10.1523/jneurosci.3447-09.2009

Anti-inflammatory cytokine gene therapy decreases sensory and motor dysfunction in experimental Multiple Sclerosis: MOG-EAE behavioral and anatomical symptom treatment with cytokine gene therapy

Autor: Kirk W. Johnson, Annemarie Ledeboer, Steven F. Maier, Erin D. Milligan, Linda R. Watkins, Raymond A. Chavez, Leslie A. Leinwand, W Seibert, Evan M. Sloane, Benjamen D. Coats, A.M. Van Dam, M van Strien

Publikováno v: Brain Behavior and Immunity, 23(1), 92-100. Academic Press Inc.
Sloane, E, Ledeboer, A, Seibert, W, Coats, B, van Strien, M, Maier, S F, Johnson, K W, Chavez, R, Watkins, L R, Leinwand, L, Milligan, E D & Van Dam, A M 2009, ' Anti-inflammatory cytokine gene therapy decreases sensory and motor dysfunction in experimental Multiple Sclerosis : MOG-EAE behavioral and anatomical symptom treatment with cytokine gene therapy ', Brain Behavior and Immunity, vol. 23, no. 1, pp. 92-100 . https://doi.org/10.1016/j.bbi.2008.09.004

Multiple Sclerosis (MS) is an autoimmune inflammatory disease that presents clinically with a range of symptoms including motor, sensory, and cognitive dysfunction as well as demyelination and lesion formation in brain and spinal cord. A variety of a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64858d2b08e625d97e036fe82e631e77
https://doi.org/10.1016/j.bbi.2008.09.004

Intrathecal interleukin-10 gene therapy attenuates paclitaxel-induced mechanical allodynia and proinflammatory cytokine expression in dorsal root ganglia in rats

Autor: Erin D. Milligan, Stephen J. Langer, Leslie A. Leinwand, David Martin, Evan M. Sloane, Kirk W. Johnson, Brian M. Jekich, Raymond A. Chavez, Linda R. Watkins, Steven F. Maier, John H. Mahoney, Annemarie Ledeboer

Publikováno v: Brain, Behavior, and Immunity. 21:686-698

Paclitaxel is a commonly used cancer chemotherapy drug that frequently causes painful peripheral neuropathies. The mechanisms underlying this dose-limiting side effect are poorly understood. Growing evidence supports that proinflammatory cytokines, s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a45673d95cc76ec638d5d6b752d703ea
https://doi.org/10.1016/j.bbi.2006.10.012

Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation

Autor: Matthew G. Frank, Erin D. Milligan, Linda R. Watkins, Steven F. Maier, John H. Mahony, Annemarie Ledeboer, Evan M. Sloane

Publikováno v: Pain. 115:71-83

Activated glial cells (microglia and astroglia) in the spinal cord play a major role in mediating enhanced pain states by releasing proinflammatory cytokines and other substances thought to facilitate pain transmission. In the present study, we repor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ad35f9e0edc7b38a43e196567af0d9b
https://doi.org/10.1016/j.pain.2005.02.009

Release of plasmid DNA-encoding IL-10 from PLGA microparticles facilitates long-term reversal of neuropathic pain following a single intrathecal administration

Autor: Evan M. Sloane, Erin D. Milligan, Luke D. Amer, Linda R. Watkins, Scott M. Johnson, Stephen Poole, Makenzie T. Lewis, Jacqueline A. Harrison, Ellen C. Dengler, Courtney S. Young, Melissa J. Mahoney, Lisa C. Loram, Ryan G. Soderquist, Matthew G. Frank

Publikováno v: Pharmaceutical research. 27(5)

Interleukin-10 (IL-10) is an anti-inflammatory molecule that has achieved interest as a therapeutic for neuropathic pain. In this work, the potential of plasmid DNA-encoding IL-10 (pDNA-IL-10) slowly released from biodegradable microparticles to prov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4453bba4248739cceee76f2e770e1633
https://pubmed.ncbi.nlm.nih.gov/20224990