Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Evan M. McIntosh"'
Autor:
Evan M. McIntosh, J. Bryan McNeil, Robert H. Haynes, K.-Peter Stahmann, Nora Tsao, Ronald E. Pearlman, Nicole Monschau, Jennifer Flynn
Publikováno v:
Yeast. 16:167-175
Genes encoding the mitochondrial (SHM1) and cytosolic (SHM2) serine hydroxymethyltransferases, and the L-threonine aldolase gene (GLY1) from Candida albicans were cloned and sequenced. All three genes are involved in glycine metabolism. The C. albica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2570fd16253cdb8a47990e3317482cb
https://doi.org/10.1002/(sici)1097-0061(20000130)16:2<167::aid-yea519>3.0.co
https://doi.org/10.1002/(sici)1097-0061(20000130)16:2<167::aid-yea519>3.0.co
Structure/function analysis of a dUTPase: catalytic mechanism of a potential chemotherapeutic target
Publikováno v:
Journal of Molecular Biology. 288:275-287
dUTP pyrophosphatase catalyses hydrolysis of deoxyuridine triphosphate (dUTP) to deoxyuridine monophosphate (dUMP) and inorganic pyrophosphate (PPi). Elimination of dUTP is vital since its misincorporation into DNA by DNA polymerases can initiate a d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b858012c7cce318744d9f6d81531c68c
https://doi.org/10.1006/jmbi.1999.2680
https://doi.org/10.1006/jmbi.1999.2680
Autor:
Evan M. McIntosh, Robert H. Haynes
Publikováno v:
Acta Biochimica Polonica. 44:159-171
Aberrant dUTP metabolism plays a critical role in the molecular mechanism of cell killing induced by inhibitors of dihydrofolate reductase and thymidylate synthase. While considerable effort has been directed towards discovering new, more potent inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::330f924d7ccfc765c81b5462dac0dd33
https://doi.org/10.18388/abp.1997_4410
https://doi.org/10.18388/abp.1997_4410
Publikováno v:
Biochemistry and Cell Biology. 75:143-151
Amino acid sequence comparisons have revealed that a potential dUTPase gene is encoded by the retrovirus HERV-K, a defective multicopy virus that is transmitted vertically in humans. This gene is distinct from the human cellular dUTPase gene and thus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa1735232f0dbacc926f7fbde70ef237
https://doi.org/10.1139/o97-027
https://doi.org/10.1139/o97-027
Autor:
Evan M. McIntosh, Robert H. Haynes
Publikováno v:
Acta Biochimica Polonica. 43:583-592
The enzyme dUTP pyrophosphatase (dUTPase, EC 3.6.1.23) is essential for cellular DNA replication and cell viability by virtue of its role in reducing the availability of dUTP as a substrate for DNA polymerases. Several members of the onco- and lentiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b71872d38d32dc8c6cccb66214a72081
https://doi.org/10.18388/abp.1996_4454
https://doi.org/10.18388/abp.1996_4454
Publikováno v:
Structure. 4:1077-1092
Background The essential enzyme dUTP pyrophosphatase (dUTPase) is exquisitely specific for dUTP and is critical for the fidelity of DNA replication and repair. dUTPase hydrolyzes dUTP to dUMP and pyrophosphate, simultaneously reducing dUTP levels and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99824e87fb9be5416f9a83e2dc925e41
https://doi.org/10.1016/s0969-2126(96)00114-1
https://doi.org/10.1016/s0969-2126(96)00114-1
Autor:
Bernard A. Kunz, Thomas A. Kunkel, Christopher K. Mathews, Evan M. McIntosh, John A. Reidy, Susanne E. Kohalmi
Publikováno v:
Mutation Research/Reviews in Genetic Toxicology. 318:1-64
DNA precursor pool imbalances can elicit a variety of genetic effects and modulate the genotoxicity of certain DNA-damaging agents. These and other observations indicate that the control of DNA precursor concentrations is essential for the maintenanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76c5e26ea26c254f00328881caaaca82
https://doi.org/10.1016/0165-1110(94)90006-x
https://doi.org/10.1016/0165-1110(94)90006-x
Publikováno v:
The EMBO Journal. 12:4425-4431
dUTP pyrophosphatase (dUTPase; EC 3.6.1.23) catalyses the hydrolysis of dUTP to dUMP and PPi and thereby prevents the incorporation of uracil into DNA during replication. Although it is widely believed that dUTPase is essential for cell viability bec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc02f831f5ff02fbbbe440fb9cf89c26
https://doi.org/10.1002/j.1460-2075.1993.tb06127.x
https://doi.org/10.1002/j.1460-2075.1993.tb06127.x
Publikováno v:
Proceedings of the National Academy of Sciences. 89:8020-8024
Two functional human dUTP pyrophosphatase (dUTPase; EC 3.6.1.23) cDNAs were isolated from a cDNA expression library by genetic complementation in Escherichia coli. These cDNAs differed in size but exhibited a common overlapping DNA sequence. Containe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbe3f5e0707c7e4d8f83d4259314cd3b
https://doi.org/10.1073/pnas.89.17.8020
https://doi.org/10.1073/pnas.89.17.8020
Publikováno v:
Current genetics. 26(5-6)
The Candida albicans dUTP pyrophosphatase (dUTPase) gene DUT1 has been isolated by genetic complementation in S. cerevisiae. It was found to encode a 17-kDa protein similar in amino-acid sequence to dUTPases isolated from other systems. The gene was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92beb9ddbf5a4814722c1ba685a0def8
https://pubmed.ncbi.nlm.nih.gov/7874734
https://pubmed.ncbi.nlm.nih.gov/7874734