Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Evan Lyerly"'
Autor:
Tanmoy Mondal, Gururaj N Shivange, Rachisan GT Tihagam, Evan Lyerly, Michael Battista, Divpriya Talwar, Roxanna Mosavian, Karol Urbanek, Narmeen S Rashid, J Chuck Harrell, Paula D Bos, Edward B Stelow, M Sharon Stack, Sanchita Bhatnagar, Jogender Tushir‐Singh
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 3, Pp 1-28 (2021)
Abstract Lack of effective immune infiltration represents a significant barrier to immunotherapy in solid tumors. Thus, solid tumor‐enriched death receptor‐5 (DR5) activating antibodies, which generates tumor debulking by extrinsic apoptotic cyto
Externí odkaz:
https://doaj.org/article/e6ee9e69e03c47dd8affba2d3b2379e8
Autor:
Gururaj Shivange, Tanmoy Mondal, Evan Lyerly, Sanchita Bhatnagar, Charles N. Landen, Shivani Reddy, Jonathan Kim, Britney Doan, Paula Riddle, Jogender Tushir-Singh
Publikováno v:
Cell Reports, Vol 37, Iss 5, Pp 109953- (2021)
Summary: Receptor clustering is the first and critical step to activate apoptosis by death receptor-5 (DR5). The recent discovery of the autoinhibitory DR5 ectodomain has challenged the long-standing view of its mechanistic activation by the natural
Externí odkaz:
https://doaj.org/article/60c0e8c51e324df1a195182838329e2c
Autor:
Roxanna Mosavian, J. Chuck Harrell, Michael Battista, M Sharon Stack, Sanchita Bhatnagar, Jogender Tushir-Singh, Rachisan Gt Tihagam, Paula D Bos, Evan Lyerly, Narmeen S. Rashid, Divpriya Talwar, Edward B. Stelow, Karol Urbanek, Tanmoy Mondal, Gururaj Shivange
Publikováno v:
EMBO molecular medicine, vol 13, iss 3
EMBO Molecular Medicine, Vol 13, Iss 3, Pp n/a-n/a (2021)
EMBO Molecular Medicine
EMBO Molecular Medicine, Vol 13, Iss 3, Pp n/a-n/a (2021)
EMBO Molecular Medicine
Lack of effective immune infiltration represents a significant barrier to immunotherapy in solid tumors. Thus, solid tumor‐enriched death receptor‐5 (DR5) activating antibodies, which generates tumor debulking by extrinsic apoptotic cytotoxicity,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6abe71cd79e53b533dc00b47a4172a4
https://escholarship.org/uc/item/1x36b8bh
https://escholarship.org/uc/item/1x36b8bh
Publikováno v:
Journal of Visualized Experiments.
Monoclonal antibodies are high affinity multifunctional drugs that work by variable independent mechanisms to eliminate cancer cells. Over the last few decades, the field of antibody-drug conjugates, bispecific antibodies, chimeric antigen receptors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1216d3aa986157540b309d6f695869b8
https://doi.org/10.3791/60727
https://doi.org/10.3791/60727
Autor:
Sanchita Bhatnagar, Jogender Tushir-Singh, Gururaj Shivange, Tanmoy Mondal, Britney Doan, Charles N. Landen, Evan Lyerly, Jonathan Kim, Shivani Reddy, Paula Riddle
Publikováno v:
Cell reports
Cell reports, vol 37, iss 5
Cell Reports, Vol 37, Iss 5, Pp 109953-(2021)
Cell reports, vol 37, iss 5
Cell Reports, Vol 37, Iss 5, Pp 109953-(2021)
SUMMARY Receptor clustering is the first and critical step to activate apoptosis by death receptor-5 (DR5). The recent discovery of the autoinhibitory DR5 ectodomain has challenged the long-standing view of its mechanistic activation by the natural l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32a0b5ec801612b28003d20aad7a8fdb
https://doi.org/10.1016/j.celrep.2021.109953
https://doi.org/10.1016/j.celrep.2021.109953