Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Evan Lubanszky"'
Autor:
Evan Lubanszky, Cynthia Hawkins
Publikováno v:
Glioma, Vol 5, Iss 1, Pp 5-11 (2022)
Pediatric high-grade gliomas (pHGGs) are the leading cause of tumor-related death in children, with diffuse midline gliomas representing the worst prognoses. Despite decades of clinical trials, no effective treatment has been found, and we are in des
Externí odkaz:
https://doaj.org/article/4407fbdccd5a409f8a448e04eb8861de
Autor:
Robert Siddaway, Laura Canty, Sanja Pajovic, Scott Milos, Etienne Coyaud, Stefanie-Grace Sbergio, Arun Kumaran Vadivel Anguraj, Evan Lubanszky, Hwa Young Yun, Alessia Portante, Sheyenne Carette, Cunjie Zhang, Michael F. Moran, Brian Raught, Eric I. Campos, Cynthia Hawkins
Publikováno v:
Acta Neuropathologica. 144:1027-1048
Histone H3 mutations at amino acids 27 (H3K27M) and 34 (H3G34R) are recurrent drivers of pediatric-type high-grade glioma (pHGG). H3K27M mutations lead to global disruption of H3K27me3 through dominant negative PRC2 inhibition, while H3G34R mutations
Publikováno v:
Journal of Neuro-Oncology. 150:27-34
Our understanding of diffuse midline glioma (DMG) biology inclusive of diffuse intrinsic pontine glioma has been revolutionized by the discovery of novel mutations on the tails of histone 3, leading to the reclassification in 2016 of ‘diffuse midli
Autor:
Etienne Coyaud, Sheyenne Carette, Haley Yun, Stefanie-Grace Sbergio, Sanja Pajovic, Robert Siddaway, Cynthia Hawkins, Scott Milos, Laura Canty, Alessia Portante, Brian Raught, Eric Campos, Evan Lubanszky
Publikováno v:
Neuro Oncol
Mutations in histone H3 at amino acids 27 (H3K27M) and 34 (H3G34R) occur with high-frequency in pediatric high-grade glioma. H3K27M mutations have been shown to lead to global disruption of H3K27me3 through dominant negative PRC2 inhibition with acco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4539177c8f68a138cd55721de1cb0071
https://europepmc.org/articles/PMC8598539/
https://europepmc.org/articles/PMC8598539/
Autor:
Cynthia Hawkins, Evan Lubanszky
Publikováno v:
Glioma. 5:5
Autor:
Evan Lubanszky, Byunjin Kim, Sanja Pajovic, Cynthia Hawkins, Robert Siddaway, Taylor Bridge, Scott Ryall
Publikováno v:
Cancer Research. 80:A35-A35
Diffuse intrinsic pontine glioma (DIPG) is a devastating pediatric high-grade glioma (HGG) that diffusely penetrates the brainstem and is the leading cause of pediatric brain tumor death. Around 80% of DIPGs harbor lysine 27-methionine (K27M) substit