Výsledky vyhledávání - "Evan J. Carder"

Targeted Degradation of mRNA Decapping Enzyme DcpS by a VHL-Recruiting PROTAC

Autor: Jake C. Swartzel, Michael J. Bond, Andreas P. Pintado-Urbanc, Mehana Daftary, Mackenzie W. Krone, Todd Douglas, Evan J. Carder, Joshua T. Zimmer, Takahiro Maeda, Matthew D. Simon, Craig M. Crews

Publikováno v: ACS Chemical Biology. 17:1789-1798

The RNA decapping scavenger protein, DcpS, has recently been identified as a dependency in acute myeloid leukemia (AML). The potent DcpS inhibitor RG3039 attenuates AML cell viability, and shRNA knockdown of DcpS is also antiproliferative. Importantl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2dbc1f4df166eac81299905db0dd4b9
https://doi.org/10.1021/acschembio.2c00145

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Akademický článek

SD-208, a novel protein kinase D inhibitor, blocks prostate cancer cell proliferation and tumor growth in vivo by inducing G2/M cell cycle arrest.

Autor: Manuj Tandon, Joseph M Salamoun, Evan J Carder, Elisa Farber, Shuping Xu, Fan Deng, Hua Tang, Peter Wipf, Q Jane Wang

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0119346 (2015)

Protein kinase D (PKD) has been implicated in many aspects of tumorigenesis and progression, and is an emerging molecular target for the development of anticancer therapy. Despite recent advancement in the development of potent and selective PKD smal

Externí odkaz: https://doaj.org/article/b4084e7bf315423b85300d578102fcb5

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Targeting p75 neurotrophin receptors ameliorates spinal cord injury-induced detrusor sphincter dyssynergia in mice

Autor: Christopher H. Fry, Samuel Getchell, Evan J. Carder, Naoki Yoshimura, Irina Zabbarova, Khalifa Almansoori, Youko Ikeda, Lori A. Birder, Pradeep Tyagi, Anthony Kanai, Marcus J. Drake, Amanda Wolf-Johnston, Peter Wipf

Publikováno v: Zabbarova, I V, Ikeda, Y, Carder, E J, Wipf, P, Wolf-Johnston, A S, Birder, L A, Yoshimura, N, Getchell, S E, Almansoori, K, Tyagi, P, Fry, C H, Drake, M J & Kanai, A J 2018, ' Targeting p75 neurotrophin receptors ameliorates spinal cord injury-induced detrusor sphincter dyssynergia in mice ', Neurourology and Urodynamics . https://doi.org/10.1002/nau.23722

Aims: To determine the role of p75 neurotrophin receptor (p75NTR) and the therapeutic effect of the selective small molecule p75NTR modulator, LM11A-31, in spinal cord injury (SCI) induced lower urinary tract dysfunction (LTUD) using a mouse model. M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcd0778aeb66860527060fd40d0bdfe9
https://pubmed.ncbi.nlm.nih.gov/29806700

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Rapid Analysis of Residual Palladium in Pharmaceutical Development Using a Catalysis-Based Fluorometric Method

Autor: Christopher J. Welch, Kazunori Koide, Evan J. Carder, Xiaodong Bu

Publikováno v: Organic Process Research & Development. 17:108-113

Measurement of residual metals in pharmaceutical intermediates is routinely performed using inductively coupled plasma-optical emission spectroscopy (ICP-OES) or inductively coupled plasma-mass spectrometry (ICP-MS). However, these techniques suffer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5a8c77fe6f999001e4316fd2dd818dcb
https://doi.org/10.1021/op3003008

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Studies toward an ideal fluorescence method to measure palladium in functionalized organic molecules: effects of sodium borohydride, temperature, phosphine ligand, and phosphate ions on kinetics

Autor: Clare C. Kohler, Fengling Song, Kazunori Koide, Evan J. Carder

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany). 16(45)

Residual metals in fine chemicals are currently detected by using inductively coupled plasma mass spectrometry, which requires expensive instrumentation and does not have high-throughput capabilities. Although fluorescent probes can be amenable to hi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aef2b1adef0d44180ae0e885406d18d0
https://pubmed.ncbi.nlm.nih.gov/20938936

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SD-208, a Novel Protein Kinase D Inhibitor, Blocks Prostate Cancer Cell Proliferation and Tumor Growth In Vivo by Inducing G2/M Cell Cycle Arrest

Autor: Peter Wipf, Shuping Xu, Q. Jane Wang, Hua Tang, Manuj Tandon, Joseph M. Salamoun, Fan Deng, Evan J. Carder, Elisa Farber

Publikováno v: PLoS ONE
PLoS ONE, Vol 10, Iss 3, p e0119346 (2015)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::304ba15132adc0eb0f18d8166943b08c
https://doi.org/10.1371/journal.pone.0119346

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Abstract 2182: Novel ATP-competitive protein kinase D inhibitors: in vitro characterization and SAR analysis

Autor: James K. Johnson, Qiming J. Wang, Manuj Tandon, Peter Wipf, Elisa Farber, Evan J. Carder

Publikováno v: Cancer Research. 73:2182-2182

Protein Kinase Ds (PKDs) are serine/threonine kinases targeted by the second messenger diacylglycerol. The three isoforms of PKD (PKD1, PKD2, and PKD3) have emerged as key mediators in diverse cellular processes pertaining to cancer development inclu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::97d846672f1402a21117a6b6ff406269
https://doi.org/10.1158/1538-7445.am2013-2182

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