Zobrazeno 1 - 10
of 174
pro vyhledávání: '"Evan J Begg"'
Autor:
Sharon J Gardiner, Philip G Drennan, Ronald Begg, Mei Zhang, Jared K Green, Heather L Isenman, Richard J Everts, Stephen T Chambers, Evan J Begg
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0199370 (2018)
It is usually recommended that flucloxacillin is given on an empty stomach. The aim of this study was to compare total and free flucloxacillin concentrations after oral flucloxacillin, given with and without food, based on contemporary pharmacokineti
Externí odkaz:
https://doaj.org/article/ed5476a8638c4f73b05e60bf8a057552
Autor:
Stephen T. Chambers, Mei Zhang, Ronald Begg, Richard J. Everts, John D. Turnidge, Sharon J. Gardiner, Evan J. Begg
Publikováno v:
Journal of Infection. 83:182-189
Objectives: We evaluated the effects of probenecid on the Pharmaco Kinetics (PK) and pharmacodynamics (PD) of oral cephalexin in healthy volunteers. Methods: Cephalexin 1000 mg was administered orally to 11 healthy volunteers following a standardized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::179b1ddeb3fc43ee945ed98cb4e61774
https://doi.org/10.1016/j.jinf.2021.05.037
https://doi.org/10.1016/j.jinf.2021.05.037
Publikováno v:
Therapeutic Drug Monitoring. 40:682-692
BACKGROUND Pharmacokinetic studies and therapeutic drug monitoring of antibiotics require a simple, rapid, and reliable analytical method for monitoring the concentrations in plasma, including unbound concentrations for highly protein-bound drugs. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40c1de335c39f538273831a4629c6ceb
https://doi.org/10.1097/ftd.0000000000000555
https://doi.org/10.1097/ftd.0000000000000555
Autor:
Paul K. L. Chin, Philip G. Drennan, Simon C. Dalton, Stephen T. Chambers, Sharon J. Gardiner, Mei Zhang, Evan J. Begg
Publikováno v:
British Journal of Clinical Pharmacology. 84:2311-2316
AIMS Flucloxacillin dosing may be guided by measurement of its total plasma concentrations. Flucloxacillin is highly protein bound with fraction unbound in plasma (fu ) of around 0.04 in healthy individuals. The utility of measuring unbound flucloxac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc454195fb6907443892add31779be09
https://doi.org/10.1111/bcp.13673
https://doi.org/10.1111/bcp.13673
Publikováno v:
International journal of antimicrobial agents. 53(4)
We have evaluated the literature to review optimal dosing and monitoring of intravenous vancomycin in adults, in response to evolving understanding of targets associated with efficacy and toxicity. The area under the total concentration-time curve (0
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79b43b64c49dea0bd842264a2a1b6fba
https://pubmed.ncbi.nlm.nih.gov/30599240
https://pubmed.ncbi.nlm.nih.gov/30599240
Autor:
John D. Turnidge, Mei Zhang, Stephen T. Chambers, Richard J. Everts, Evan J. Begg, Sharon J. Gardiner, Ronald Begg
Publikováno v:
The Journal of infection. 80(1)
To measure the effect of probenecid, fasting and fed, on flucloxacillin pharmacokinetic and pharmacodynamic endpoints.Flucloxacillin 1000 mg orally was given to 11 volunteers alone while fasting ('flucloxacillin alone'), and with probenecid 500 mg or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50cb81d639b96e810bd1cb3f12d4523c
https://pubmed.ncbi.nlm.nih.gov/31521742
https://pubmed.ncbi.nlm.nih.gov/31521742
The transfer of drugs and other xenobiotics to the infant via breast milk is a frequent cause for concern. Many women who require pharmacological therapy interrupt or stop breastfeeding, or fail to take the prescribed treatment regimen because of per
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6da1008e44499a905452d4933536f3ec
https://doi.org/10.1016/b978-0-12-801238-3.02154-1
https://doi.org/10.1016/b978-0-12-801238-3.02154-1
Publikováno v:
British Journal of Clinical Pharmacology. 79:268-277
Aims We aimed to compare the performances of contemporary cystatin C (Cys)-based GFR equations, and the creatinine only Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation for predicting gentamicin clearance. Methods The bias and imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88b7f014574f2e3692db111907b77731
https://doi.org/10.1111/bcp.12501
https://doi.org/10.1111/bcp.12501
Autor:
Facundo Garcia Bournissen, Anna Taddio, Judith H. Kristensen, Kenneth F. Ilett, Izhar Wallach, Evan J. Begg, Reo Tanoshima, Yusuke Tanigawara, Shinya Ito
Publikováno v:
British Journal of Clinical Pharmacology. 78:918-928
Aims Population pharmacokinetic (pop PK) modelling can be used for PK assessment of drugs in breast milk. However, complex mechanistic modelling of a parent and an active metabolite using both blood and milk samples is challenging. We aimed to develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45d06ec4e7b697eb53b0688cf15e0e7e
https://doi.org/10.1111/bcp.12409
https://doi.org/10.1111/bcp.12409
Autor:
Berit P. Jensen, Mei Zhang, Daniel F. B. Wright, Murray L. Barclay, David M. Patterson, Evan J. Begg, Paul K. L. Chin
Publikováno v:
British Journal of Clinical Pharmacology. 78:630-638
Aims In patients with atrial fibrillation prescribed dabigatran, the aim was to examine the correlation between plasma dabigatran concentrations and the three screening coagulation assays [international normalized ratio (INR), activated partial throm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58b878ce4aeee43f235e5aee98edf698
https://doi.org/10.1111/bcp.12366
https://doi.org/10.1111/bcp.12366