Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Evan Hess"'
1
Akademický článek
511 Eliminating System xc- Signaling Between Astrocytes and Neurons Selectively Impairs Complex Cognition
Autor: Gregory Simandl, Gregory J. Simandl, Evan Hess, Linghai Kong, Nicholas J. Raddatz, Matthew M. Hurley, Brian Maunze, SuJean Choi, Aaron M. Geurts, David A. Baker
Publikováno v: Journal of Clinical and Translational Science, Vol 7, Pp 145-145 (2023)
OBJECTIVES/GOALS: We aim to discover safer and more effective therapeutics for CNS disorders. Current therapeutic development is hindered by dosing out drugs for safe consumption. By identifying proteins with narrow functional roles in the brain (i.e
Externí odkaz: https://doaj.org/article/e95a333379c64267a47095434505eef3
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2
Akademický článek
401 Eliminating System xc- Signaling Between Astrocytes and Neurons Selectively Impairs Complex Cognition
Autor: Gregory Simand, Gregory J. Simand, Evan Hess, Linghai Kong, Nicholas J. Raddatz, Matthew M Hurley, Brian Maunze, SuJean Choi, Aron M. Geurts, David A. Baker
Publikováno v: Journal of Clinical and Translational Science, Vol 6, Pp 76-76 (2022)
OBJECTIVES/GOALS: We aim to determine whether non-neuronal, non-synaptic glutamate signaling mechanisms can be targeted to produce highly specific, narrow changes in brain function that would benefit CNS disorders. To do this, we investigated cogniti
Externí odkaz: https://doaj.org/article/f0d5bc85c7a9421885ab6fab76126b3b
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3
Akademický článek
Combined chondroitinase and KLF7 expression reduce net retraction of sensory and CST axons from sites of spinal injury
Autor: Zimei Wang, Kristen Winsor, Christopher Nienhaus, Evan Hess, Murray G. Blackmore
Publikováno v: Neurobiology of Disease, Vol 99, Iss , Pp 24-35 (2017)
Axon regeneration in the central nervous system is limited both by inhibitory extracellular cues and by an intrinsically low capacity for axon growth in some CNS populations. Chondroitin sulfate proteoglycans (CSPGs) are well-studied inhibitors of ax
Externí odkaz: https://doaj.org/article/0b517d3f0e0a4b00b3edc22c918fa895
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5
Acute Blockade of PACAP-Dependent Activity in the Ventromedial Nucleus of the Hypothalamus Disrupts Leptin-Induced Behavioral and Molecular Changes in Rats
Autor: SuJean Choi, Matthew M. Hurley, Megan E. Block, Tanya Dabra, Neerali Patel, Matthew Hearing, Riley McCoy, Michael J. Reilly, William Conley, Eden M. Anderson, Christopher Chen, Brian Maunze, Zane Cooper, Evan Hess
Publikováno v: Neuroendocrinology
Leptin signaling pathways, stemming primarily from the hypothalamus, are necessary for maintaining normal energy homeostasis and body weight. In both rodents and humans, dysregulation of leptin signaling leads to morbid obesity and diabetes. Since le
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67a0b94632a6d9c31690ee11b8a6c545
https://doi.org/10.1159/000501337
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6
Suppression of pyramidal neuron G protein-gated inwardly rectifying K+ channel signaling impairs prelimbic cortical function and underlies stress-induced deficits in cognitive flexibility in male, but not female, mice
Autor: Skyler Demis, Kevin Wickman, Evan Hess, Eden M. Anderson, Kevin O’Reilly, Benjamin Wrucke, Matthew Hearing, Annabel Engelhardt, Steven Loke
Publikováno v: Neuropsychopharmacology
Imbalance in prefrontal cortical (PFC) pyramidal neuron excitation:inhibition is thought to underlie symptomologies shared across stress-related disorders and neuropsychiatric disease, including dysregulation of emotion and cognitive function. G prot
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3772562d042054315c4c572798fe0293
https://pubmed.ncbi.nlm.nih.gov/34158613
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7
Suppression of pyramidal neuron G protein-gated inwardly rectifying K+ channel signaling impairs prelimbic cortical function and underlies stress-induced deficits in cognitive flexibility
Autor: Eden M Anderson, Steven Loke, Benjamin Wrucke, Annabel Engelhardt, Evan Hess, Kevin Wickman, Matthew C Hearing
BackgroundImbalance in prefrontal cortical (PFC) pyramidal neuron excitation:inhibition is thought to underlie symptomologies shared across stress-related disorders and neuropsychiatric disease, including dysregulation of emotion and cognitive functi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e32f855b73b4a8f481e0acc40f525027
https://doi.org/10.1101/2020.06.08.139725
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8
Combined chondroitinase and KLF7 expression reduce net retraction of sensory and CST axons from sites of spinal injury
Autor: Kristen N. Winsor, Murray Blackmore, Christopher Nienhaus, Zimei Wang, Evan Hess
Publikováno v: Neurobiology of Disease, Vol 99, Iss, Pp 24-35 (2017)
Axon regeneration in the central nervous system is limited both by inhibitory extracellular cues and by an intrinsically low capacity for axon growth in some CNS populations. Chondroitin sulfate proteoglycans (CSPGs) are well-studied inhibitors of ax
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac1b2467bec21f3d7cfb470ad2a7c0de
https://doi.org/10.1016/j.nbd.2016.12.010
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10
Glial Dysregulation in Addiction
Autor: Evan Hess, Matthew Hearing, David A. Baker, Aric Madayag
Addiction is a neuropsychiatric disorder characterized by uncontrolled drug use and heightened relapse susceptibility. While brain regions controlling multiple aspects of human behavior are known to be dysregulated by drugs of abuse, our limited unde
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d680e1a44a4469a104e64949b561c75f
https://doi.org/10.1016/b978-0-12-812202-0.00016-6
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