Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Evan Healy"'
Autor:
Evan Healy, Qi Zhang, Emma H. Gail, Samuel C. Agius, Guizhi Sun, Michael Bullen, Varun Pandey, Partha Pratim Das, Jose M. Polo, Chen Davidovich
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113858- (2024)
Summary: RNA has been implicated in the recruitment of chromatin modifiers, and previous studies have provided evidence in favor and against this idea. RNase treatment of chromatin is commonly used to study RNA-mediated regulation of chromatin modifi
Externí odkaz:
https://doaj.org/article/88dbe8b8c5604e04891cc64837a90818
Autor:
Vivien Grant, Dáire Gannon, Eimear Lagan, Neza Alfazema, Craig Monger, Steven M. Pollard, Hannah K. Neikes, Orla Deevy, Darren J. Fitzpatrick, Raul Bardini Bressan, Evan Healy, Maria-Angeles Marqués-Torrejón, Adrian P. Bracken, Anthony M Doherty, Gerard L. Brien
Publikováno v:
Brien, G L, Bressan, R B, Monger, C, Gannon, D, Lagan, E, Doherty, A M, Healy, E, Neikes, H, Fitzpatrick, D J, Deevy, O, Grant, V, Marqués-Torrejón, M-A, Alfazema, N, Pollard, S M & Bracken, A P 2021, ' Simultaneous disruption of PRC2 and enhancer function underlies histone H3.3-K27M oncogenic activity in human hindbrain neural stem cells ', Nature Genetics, vol. 53, no. 8, pp. 1221-1232 . https://doi.org/10.1038/s41588-021-00897-w
Driver mutations in genes encoding histone H3 proteins resulting in p.Lys27Met substitutions (H3-K27M) are frequent in pediatric midline brain tumors. However, the precise mechanisms by which H3-K27M causes tumor initiation remain unclear. Here, we u
Autor:
Evan Healy, Rachel McCole, Craig Monger, James Nolan, Eric Conway, Gerard Brien, Cheng Wang, Hannah K Neikes, Frances Potjewyd, Michiel Vermeulen, Aoibhinn Mooney, Richard Flavin, Elisabeth Vandenberghe, Lindsey I James, Adrian P Bracken
Publikováno v:
Blood. 140:3049-3050
Autor:
Eleanor Glancy, Cheng Wang, Ellen Tuck, Evan Healy, Simona Amato, Hannah K. Neikes, Andrea Mariani, Marlena Mucha, Michiel Vermeulen, Diego Pasini, Adrian P. Bracken
Publikováno v:
Molecular Cell, 83, 1393-1411.e7
Molecular Cell, 83, 9, pp. 1393-1411.e7
Molecular Cell, 83, 9, pp. 1393-1411.e7
Contains fulltext : 292848.pdf (Publisher’s version ) (Open Access)
Autor:
Evan Healy, Rachel McCole, Craig Monger, Gerald L. Brien, Cheng Wang, Hannah K. Neikes, Frances Potjewyd, Michiel Vermeulen, Lindsey Ingerman James, Adrian Bracken
Publikováno v:
SSRN Electronic Journal.
Autor:
Gerard L, Brien, Raul Bardini, Bressan, Craig, Monger, Dáire, Gannon, Eimear, Lagan, Anthony M, Doherty, Evan, Healy, Hannah, Neikes, Darren J, Fitzpatrick, Orla, Deevy, Vivien, Grant, Maria-Angeles, Marqués-Torrejón, Neza, Alfazema, Steven M, Pollard, Adrian P, Bracken
Publikováno v:
Nature genetics. 53(8)
Driver mutations in genes encoding histone H3 proteins resulting in p.Lys27Met substitutions (H3-K27M) are frequent in pediatric midline brain tumors. However, the precise mechanisms by which H3-K27M causes tumor initiation remain unclear. Here, we u
Autor:
Evan Healy, Adrian P. Bracken
Publikováno v:
Molecular Cell
Summary Polycomb group proteins (PcGs) maintain transcriptional repression to preserve cellular identity in two distinct repressive complexes, PRC1 and PRC2, that modify histones by depositing H2AK119ub1 and H3K27me3, respectively. PRC1 and PRC2 exis
Autor:
Evan Healy, Raphaël Margueron, Aoife McLysaght, Haruhiko Koseki, Luciano Di Croce, Darren J. Fitzpatrick, Emilia Jerman, Orla Deevy, Manabu Nakayama, Kieran Wynne, Giorgio Oliviero, Gundula Streubel, Karsten Hokamp, Adrian P. Bracken, Claudio Ciferri, Ariane Watson, Indigo Pratt-Kelly, Christine S. Huang, Paul Chammas, Marlena Mucha, Tomoyuki Ishikura, Eleanor Glancy, Gerard Cagney, Eric Conway, Shinsuke Ito, Alan M. Rice, Daniel Holoch, Yoko Koseki
Publikováno v:
Molecular cell. 70(3)
Summary The polycomb repressive complex 2 (PRC2) consists of core subunits SUZ12, EED, RBBP4/7, and EZH1/2 and is responsible for mono-, di-, and tri-methylation of lysine 27 on histone H3. Whereas two distinct forms exist, PRC2.1 (containing one pol
Publikováno v:
Proceedings of the TEI '16: Tenth International Conference on Tangible, Embedded, and Embodied Interaction.
Publikováno v:
Current opinion in cell biology. 37
The Polycomb Repressive Complex 2 (PRC2) is a multiprotein chromatin modifying complex that is essential for vertebrate development and differentiation. It is composed of a trimeric core of SUZ12, EED and EZH1/2 and is responsible for catalysing both