Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Evan G, Pappas"'
Autor:
Tingting Ge, Amber‐Lee Phung, Gaurang Jhala, Prerak Trivedi, Nicola Principe, David J De George, Evan G Pappas, Sara Litwak, Laura Sanz‐Villanueva, Tara Catterall, Stacey Fynch, Louis Boon, Thomas W Kay, Jonathan Chee, Balasubramanian Krishnamurthy, Helen E Thomas
Publikováno v:
Clinical & Translational Immunology, Vol 11, Iss 11, Pp n/a-n/a (2022)
Abstract Objectives Immune checkpoint inhibitors have achieved clinical success in cancer treatment, but this treatment causes immune‐related adverse events, including type 1 diabetes (T1D). Our aim was to test whether a JAK1/JAK2 inhibitor, effect
Externí odkaz:
https://doaj.org/article/2f238a260da54aefb12d7ef799742c6b
Autor:
Chieh-Hsin Yang, Danise Ann-Onda, Xuzhu Lin, Stacey Fynch, Shaktypreya Nadarajah, Evan G. Pappas, Xin Liu, John W. Scott, Jonathan S. Oakhill, Sandra Galic, Yanchuan Shi, Alba Moreno-Asso, Cassandra Smith, Thomas Loudovaris, Itamar Levinger, Decio L. Eizirik, D. Ross Laybutt, Herbert Herzog, Helen E. Thomas, Kim Loh
Publikováno v:
Molecular Metabolism, Vol 55, Iss , Pp 101413- (2022)
Objectives: Loss of functional β-cell mass is a key factor contributing to poor glycemic control in advanced type 2 diabetes (T2D). We have previously reported that the inhibition of the neuropeptide Y1 receptor improves the islet transplantation ou
Externí odkaz:
https://doaj.org/article/02909523106a409cb9dc517663f1220c
Autor:
Gaurang Jhala, Claudia Selck, Jonathan Chee, Chun-Ting J. Kwong, Evan G. Pappas, Helen E. Thomas, Thomas W.H. Kay, Balasubramanian Krishnamurthy
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
T-cell responses to insulin and its precursor proinsulin are central to islet autoimmunity in humans and non-obese diabetic (NOD) mice that spontaneously develop autoimmune diabetes. Mice have two proinsulin genes proinsulin -1 and 2 that are differe
Externí odkaz:
https://doaj.org/article/2e4f4427f77c4d30acd6cfc411dba09c
Autor:
Tingting Ge, Gaurang Jhala, Stacey Fynch, Satoru Akazawa, Sara Litwak, Evan G. Pappas, Tara Catterall, Ishan Vakil, Andrew J. Long, Lisa M. Olson, Balasubramanian Krishnamurthy, Thomas W. Kay, Helen E. Thomas
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Cytokines that signal through the JAK-STAT pathway, such as interferon-γ (IFN-γ) and common γ chain cytokines, contribute to the destruction of insulin-secreting β cells by CD8+ T cells in type 1 diabetes (T1D). We previously showed that JAK1/JAK
Externí odkaz:
https://doaj.org/article/39354577fa0840eea6c38e144b21a5dd
Autor:
Helen E. Thomas, Stacey Fynch, Balasubramanian Krishnamurthy, Tara Catterall, Satoru Akazawa, Thomas C. Brodnicki, Kate L. Graham, Claudia Selck, Thomas W.H. Kay, Chun-Ting J. Kwong, Leanne Mackin, Evan G Pappas, Andrew P. R. Sutherland, Gaurang Jhala
Publikováno v:
Diabetologia. 64:878-889
Stimulator of IFN genes (STING) is a central hub for cytosolic nucleic acid sensing and its activation results in upregulation of type I IFN production in innate immune cells. A type I IFN gene signature seen before the onset of type 1 diabetes has b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cfaf809b660ae5a6174b5dc3eb53a74
https://doi.org/10.1007/s00125-020-05378-z
https://doi.org/10.1007/s00125-020-05378-z
Publikováno v:
Cancers. 15:1322
This Special Issue reminds us that, although incredible developments have occurred in the field of cancer immunotherapy, there is still plenty of room for improvement [...]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37ce10c397901f5e486cbb913138a996
https://doi.org/10.3390/cancers15041322
https://doi.org/10.3390/cancers15041322
Autor:
Sara A. Litwak, Jibran A. Wali, Evan G. Pappas, Hamdi Saadi, William J. Stanley, L. Chitra Varanasi, Thomas W. H. Kay, Helen E. Thomas, Esteban N. Gurzov
Publikováno v:
Journal of Diabetes Research, Vol 2015 (2015)
Pancreatic β-cell loss induced by saturated free fatty acids (FFAs) is believed to contribute to type 2 diabetes. Previous studies have shown induction of endoplasmic reticulum (ER) stress, increased ubiquitinated proteins, and deregulation of the B
Externí odkaz:
https://doaj.org/article/cc42862cb1e94bc789cf5a2f5e4bdf7c
Autor:
Gaurang, Jhala, Balasubramanian, Krishnamurthy, Thomas C, Brodnicki, Tingting, Ge, Satoru, Akazawa, Claudia, Selck, Prerak M, Trivedi, Evan G, Pappas, Leanne, Mackin, Nicola, Principe, Erwan, Brémaud, David J, De George, Louis, Boon, Ian, Smyth, Jonathan, Chee, Thomas W H, Kay, Helen E, Thomas
Publikováno v:
Cell reports. 39(4)
Interferon gamma (IFNγ) is a proinflammatory cytokine implicated in autoimmune diseases. However, deficiency or neutralization of IFNγ is ineffective in reducing disease. We characterize islet antigen-specific T cells in non-obese diabetic (NOD) mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::97fab22d01f9071dfdfc3f0f26da54e5
https://pubmed.ncbi.nlm.nih.gov/35476975
https://pubmed.ncbi.nlm.nih.gov/35476975
Autor:
Gaurang Jhala, Balasubramanian Krishnamurthy, Thomas C. Brodnicki, Tingting Ge, Satoru Akazawa, Claudia Selck, Prerak M. Trivedi, Evan G. Pappas, Leanne Mackin, Nicola Principe, Erwan Brémaud, David J. De George, Louis Boon, Ian Smyth, Jonathan Chee, Thomas W.H. Kay, Helen E. Thomas
Publikováno v:
Cell Reports. 39:110747
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::940f280685afe54edca60458f97f81f9
https://doi.org/10.1016/j.celrep.2022.110747
https://doi.org/10.1016/j.celrep.2022.110747
Autor:
Satoru, Akazawa, Leanne, Mackin, Gaurang, Jhala, Stacey, Fynch, Tara, Catterall, Claudia, Selck, Kate L, Graham, Balasubramanian, Krishnamurthy, Evan G, Pappas, Chun-Ting J, Kwong, Andrew P R, Sutherland, Thomas W H, Kay, Thomas C, Brodnicki, Helen E, Thomas
Publikováno v:
Diabetologia. 64(4)
Stimulator of IFN genes (STING) is a central hub for cytosolic nucleic acid sensing and its activation results in upregulation of type I IFN production in innate immune cells. A type I IFN gene signature seen before the onset of type 1 diabetes has b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5442244ec74d487ef1f213d3cce112f6
https://pubmed.ncbi.nlm.nih.gov/33483762
https://pubmed.ncbi.nlm.nih.gov/33483762