Výsledky vyhledávání

Akademický článek

Glutathione S-transferases and their implications in the lung diseases asthma and chronic obstructive pulmonary disease: Early life susceptibility?

Autor: Cheryl van de Wetering, Evan Elko, Marijn Berg, Caspar H.J. Schiffers, Vasili Stylianidis, Maarten van den Berge, Martijn C. Nawijn, Emiel F.M. Wouters, Yvonne M.W. Janssen-Heininger, Niki L. Reynaert

Publikováno v: Redox Biology, Vol 43, Iss , Pp 101995- (2021)

Our lungs are exposed daily to airborne pollutants, particulate matter, pathogens as well as lung allergens and irritants. Exposure to these substances can lead to inflammatory responses and may induce endogenous oxidant production, which can cause c

Externí odkaz: https://doaj.org/article/84d7c3a853c24a5d899f92ab394e89a4

Zobrazit plný text záznamu

Inhibition of PDIA3 in club cells attenuates osteopontin production and lung fibrosis

Autor: Amit Kumar, Sierra R. Bruno, Mona Ruban, Ying-Wai Lam, Joseph Walzer, Yvonne M. W. Janssen-Heininger, Sudhir Ghandikota, Z. Mark, Vikas Anathy, Nicolas Chamberlain, Ravishankar Chandrasekaran, Anil G. Jegga, Bethany Korwin Mihavics, Clarissa S. Gold, Evan Elko, Jose L. Gomez

Publikováno v: Thorax. 77:669-678

BackgroundThe role of club cells in the pathology of idiopathic pulmonary fibrosis (IPF) is not well understood. Protein disulfide isomerase A3 (PDIA3), an endoplasmic reticulum-based redox chaperone required for the functions of various fibrosis-rel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::304ecb8dce8d84ee5e30860050ab8fcb
https://doi.org/10.1136/thoraxjnl-2021-216882

Zobrazit plný text záznamu

Dysregulation of the glutaredoxin/S-glutathionylation redox axis in lung diseases

Autor: Yvonne M. W. Janssen-Heininger, Jos van der Velden, Evan Elko, Ying-Wai Lam, Cheryl van de Wetering, Reem Aboushousha, Charles G. Irvin, Albert van der Vliet, David J. Seward, Shi B. Chia, Joseph E Druso, Vikas Anathy, Allison M. Manuel

Publikováno v: American Journal of Physiology-Cell Physiology. 318:C304-C327

Glutathione is a major redox buffer, reaching millimolar concentrations within cells and high micromolar concentrations in airways. While glutathione has been traditionally known as an antioxidant defense mechanism that protects the lung tissue from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1125f4e2ea35174b620428b13d8379be
https://doi.org/10.1152/ajpcell.00410.2019

Zobrazit plný text záznamu

Age-dependent dysregulation of redox genes may contribute to fibrotic pulmonary disease susceptibility

Autor: Vikas Anathy, Pamela M. Vacek, Jos van der Velden, Yvonne M. W. Janssen-Heininger, Evan Elko, J. Matthew Mahoney, David J. Seward, Albert van der Vliet

Publikováno v: Free Radical Biology and Medicine. 141:438-446

Aging is associated with enhanced oxidative stress and increased susceptibility to numerous diseases. This relationship is particularly striking with respect to the incidence of fibrotic lung disease. To identify potential mechanisms underlying the a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d75db0fe63833c108e64fbf3aab8aa3
https://doi.org/10.1016/j.freeradbiomed.2019.07.011

Zobrazit plný text záznamu

Oxidation of peroxiredoxin-4 induces oligomerization and promotes interaction with proteins governing protein folding and endoplasmic reticulum stress

Autor: Vikas Anathy, Sheryl L. White, Ester Zito, Allison M. Manuel, Albert van der Vliet, Yvonne M. W. Janssen-Heininger, Evan Elko

Publikováno v: The Journal of Biological Chemistry

Peroxiredoxins (PRDXs) catalyze the reduction of hydrogen peroxide (H2O2). PRDX4 is the only peroxiredoxin located within the endoplasmic reticulum (ER) and is the most highly expressed H2O2 scavenger in the ER. PRDX4 has emerged as an important play

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab978ad4ccf33cfcfb5c91525b95949e
http://europepmc.org/articles/PMC8141880

Zobrazit plný text záznamu

Peroxiredoxins and Beyond; Redox Systems Regulating Lung Physiology and Disease

Autor: Brian Cunniff, Shi Biao Chia, Evan Elko, Nicholas H. Heintz, Jos van der Velden, Yvonne M. W. Janssen-Heininger, Vikas Anathy, Allison M. Manuel, David J. Seward, Reem Aboushousha, Arti Shukla, Cheryl van de Wetering, Albert van der Vliet

Publikováno v: Antioxid Redox Signal

Significance: The lung is a unique organ, as it is constantly exposed to air, and thus it requires a robust antioxidant defense system to prevent the potential damage from exposure to an array of environmental insults, including oxidants. The peroxir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14c01d573ba808344e3776483505eebd
https://pubmed.ncbi.nlm.nih.gov/30799628

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání