Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Evan C Lam"'
Autor:
Eike-Christian Wamhoff, Larance Ronsard, Jared Feldman, Grant A. Knappe, Blake M. Hauser, Anna Romanov, James Brett Case, Shilpa Sanapala, Evan C. Lam, Kerri J. St. Denis, Julie Boucau, Amy K. Barczak, Alejandro B. Balazs, Michael S. Diamond, Aaron G. Schmidt, Daniel Lingwood, Mark Bathe
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Protein-based virus-like particles (P-VLPs) are commonly used to spatially organize antigens and enhance humoral immunity through multivalent antigen display. However, P-VLPs are thymus-dependent antigens that are themselves immunogenic and
Externí odkaz:
https://doaj.org/article/a903d94958bc48e7ac6e79ace0aa2f9a
Autor:
Nicolas M. S. Galvez, Maegan L. Sheehan, Allen Z. Lin, Yi Cao, Evan C. Lam, Abigail M. Jackson, Alejandro B. Balazs
Publikováno v:
Viruses, Vol 16, Iss 8, p 1320 (2024)
Quantifying viral growth rates is key to understanding evolutionary dynamics and the potential for mutants to escape antiviral drugs. Defining evolutionary escape paths and their impact on viral fitness allows for the development of drugs that are re
Externí odkaz:
https://doaj.org/article/c07ea1bf5e9d451c9fe8f2ce722923a4
Autor:
Kim Vanuytsel, Carlos Villacorta-Martin, Jonathan Lindstrom-Vautrin, Zhe Wang, Wilfredo F. Garcia-Beltran, Vladimir Vrbanac, Dylan Parsons, Evan C. Lam, Taylor M. Matte, Todd W. Dowrey, Sara S. Kumar, Mengze Li, Feiya Wang, Anthony K. Yeung, Gustavo Mostoslavsky, Ruben Dries, Joshua D. Campbell, Anna C. Belkina, Alejandro B. Balazs, George J. Murphy
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
During human embryonic development, haematopoietic stem cells of the foetal liver undergo expansion, while retaining engraftment capacity. Here the authors apply CITE-seq to profile single cells from a human foetal liver, identifying a molecular sign
Externí odkaz:
https://doaj.org/article/cac11a57fa10405ca22f6fddb6df2365
Autor:
Blake M. Hauser, Maya Sangesland, Evan C. Lam, Jared Feldman, Alejandro B. Balazs, Daniel Lingwood, Aaron G. Schmidt
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Since the emergence of SARS-CoV-2 (SARS-2), multiple vaccine candidates were developed and studied both preclinically and clinically. Nearly all are based on the SARS-2 spike glycoprotein or its receptor binding domain (RBD). Studies of these vaccine
Externí odkaz:
https://doaj.org/article/202117d6ed6545219d53d114e64199c2
Autor:
Blake M. Hauser, Maya Sangesland, Kerri J. St. Denis, Evan C. Lam, James Brett Case, Ian W. Windsor, Jared Feldman, Timothy M. Caradonna, Ty Kannegieter, Michael S. Diamond, Alejandro B. Balazs, Daniel Lingwood, Aaron G. Schmidt
Publikováno v:
Cell Reports, Vol 38, Iss 12, Pp 110561- (2022)
Summary: Eliciting antibodies to surface-exposed viral glycoproteins can generate protective responses that control and prevent future infections. Targeting conserved sites may reduce the likelihood of viral escape and limit the spread of related vir
Externí odkaz:
https://doaj.org/article/9af234df3f1549f583881a398111b526
Autor:
Trenton Reinicke, Justin F. Gainor, Marissa N Bruno, Henning Willers, Erika Nakajima, Anand S. Dighe, Yi-Bin Chen, Vivek Naranbhai, Leyre Zubiri, Aleigha Lawless, Brittany Y Bertaux, Aditya Bardia, Kerry L. Reynolds, Rebecca R. Saff, Jocelyn R. Farmer, Kerri St. Denis, A. John Iafrate, Elizabeth Niehoff, Joan How, Mustafa Sakhi, Grace Kirkpatrick, Arthur Y. Kim, Wilfredo-Garcia Beltran, Alejandro B. Balazs, Alexander Gavralidis, Caroline Barabell, Monica A Jackson, C. Bowes, Lailoo A Perriello, Amir T. Fathi, Andrew M. Brunner, Evan C. Lam, Gabriela S. Hobbs, Grace Hambelton, Christian N Nambu, Kimberly G. Blumenthal, Julia Thierauf, Laura Spring, Elyssa Denault, Claire A. Pernat, Steven J. Isakoff, Ryan J. Sullivan, Cristhian J Berrios-Mairena, Jennifer L Peterson, Lindsey Mortensen, Onosereme Ofoman
Publikováno v:
Journal of Clinical Oncology. 40:12-23
PURPOSE The immunogenicity and reactogenicity of SARS-CoV-2 vaccines in patients with cancer are poorly understood. METHODS We performed a prospective cohort study of adults with solid-organ or hematologic cancers to evaluate anti–SARS-CoV-2 immuno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddd4adee9cdbccaa0dc5ecdbf943b517
https://doi.org/10.1200/jco.21.01891
https://doi.org/10.1200/jco.21.01891
Autor:
John Iafrate, Florence K. Keane, C. Bowes, Justin F. Gainor, Vivek Naranbhai, Henning Willers, Kerri St. Denis, Alejandro B. Balazs, Evan C. Lam, Brittany Y Bertaux, Melin J. Khandekar
Publikováno v:
Radiotherapy and Oncology
The immunogenicity of SARS-CoV-2 vaccines in cancer patients receiving radiotherapy is unknown. This prospective cohort study demonstrates that anti-SARS-CoV-2 spike antibody and neutralization titers are reduced in a subset of thoracic radiotherapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::428cead24f93ea80eb26f61c2dfa3fd2
https://doi.org/10.1016/j.radonc.2021.11.012
https://doi.org/10.1016/j.radonc.2021.11.012
Autor:
Jacqueline M. Brady, Meredith Phelps, Scott W. MacDonald, Evan C. Lam, Adam Nitido, Dylan Parsons, Christine L. Boutros, Cailin E. Deal, Wilfredo F. Garcia-Beltran, Serah Tanno, Harini Natarajan, Margaret E. Ackerman, Vladimir D. Vrbanac, Alejandro B. Balazs
Publikováno v:
Sci Transl Med
HIV broadly neutralizing antibodies (bNAbs) are capable of both blocking viral entry and driving innate immune responses against HIV-infected cells through their Fc region. Vaccination or productive infection results in a polyclonal mixture of class-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcbededc08cc75fe740629bd6948738c
https://europepmc.org/articles/PMC9507259/
https://europepmc.org/articles/PMC9507259/
Autor:
Htin Aung, Dennis Wilk, Sarah D. Berry, Alejandro B. Balazs, Mike C. Payne, Evan C. Lam, Christopher L. King, Stefan Gravenstein, Brigid Wilson, Christopher F. Rowley, Kerri St. Denis, Cheryl M. Cameron, Lenore L. Carias, Oladayo A. Oyebanji, Debbie Keresztesy, David H. Canaday, Mark J. Cameron
Publikováno v:
Clinical Infectious Diseases. 73:2112-2115
After BNT162b2 messenger RNA vaccination, antibody levels to spike, receptor-binding domain, and virus neutralization were examined in 149 nursing home residents and 110 healthcare worker controls. Severe acute respiratory syndrome coronavirus 2 (SAR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b48d37603ff1a8959a8571ffbab598f9
https://doi.org/10.1093/cid/ciab447
https://doi.org/10.1093/cid/ciab447
Autor:
Hong Yue, Radosław P. Nowak, Daan Overwijn, N. Connor Payne, Stephanie Fischinger, Caroline Atyeo, Evan C. Lam, Kerri St. Denis, Lauren K. Brais, Yoshinobu Konishi, Romanos Sklavenitis-Pistofidis, Lindsey R. Baden, Eric J. Nilles, Elizabeth W. Karlson, Xu G. Yu, Jonathan Z. Li, Ann E. Woolley, Irene M. Ghobrial, Jeffrey A. Meyerhardt, Alejandro B. Balazs, Galit Alter, Ralph Mazitschek, Eric S. Fischer
Publikováno v:
Cell Rep Methods
Serological assays are important diagnostic tools for surveying exposure to the pathogen, monitoring immune response post vaccination, and managing spread of the infectious agent among the population. Current serological laboratory assays are often l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54964c9bb3044c5c855bf74ca3e1976c
https://doi.org/10.1016/j.crmeth.2023.100421
https://doi.org/10.1016/j.crmeth.2023.100421