Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Evan C, Lien"'
Autor:
Rachel (Rae) J. House, Elizabeth A. Tovar, Luke N. Redlon, Curt J. Essenburg, Patrick S. Dischinger, Abigail E. Ellis, Ian Beddows, Ryan D. Sheldon, Evan C. Lien, Carrie R. Graveel, Matthew R. Steensma
Publikováno v:
Molecular Metabolism, Vol 80, Iss , Pp 101876- (2024)
Objective: NF1 is a tumor suppressor gene and its protein product, neurofibromin, is a negative regulator of the RAS pathway. NF1 is one of the top driver mutations in sporadic breast cancer such that 27 % of breast cancers exhibit damaging NF1 alter
Externí odkaz:
https://doaj.org/article/c0cfe2d8357a4b118393af5f70ecbed2
Autor:
Allison N Lau, Zhaoqi Li, Laura V Danai, Anna M Westermark, Alicia M Darnell, Raphael Ferreira, Vasilena Gocheva, Sharanya Sivanand, Evan C Lien, Kiera M Sapp, Jared R Mayers, Giulia Biffi, Christopher R Chin, Shawn M Davidson, David A Tuveson, Tyler Jacks, Nicholas J Matheson, Omer Yilmaz, Matthew G Vander Heiden
Publikováno v:
eLife, Vol 9 (2020)
Tumors are composed of many different cell types including cancer cells, fibroblasts, and immune cells. Dissecting functional metabolic differences between cell types within a mixed population can be challenging due to the rapid turnover of metabolit
Externí odkaz:
https://doaj.org/article/d77eaf4877714df6a00d2b9f769cb0f8
Autor:
Christian C. Dibble, Samuel A. Barritt, Grace E. Perry, Evan C. Lien, Renee C. Geck, Sarah E. DuBois-Coyne, David Bartee, Thomas T. Zengeya, Emily B. Cohen, Min Yuan, Benjamin D. Hopkins, Jordan L. Meier, John G. Clohessy, John M. Asara, Lewis C. Cantley, Alex Toker
Publikováno v:
Nature. 608:192-198
In response to hormones and growth factors, the class I phosphoinositide-3-kinase (PI3K) signalling network functions as a major regulator of metabolism and growth, governing cellular nutrient uptake, energy generation, reducing cofactor production a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a671b67118b568aca77aca5b34c77ee1
https://doi.org/10.1038/s41586-022-04984-8
https://doi.org/10.1038/s41586-022-04984-8
Autor:
Christopher Chidley, Alicia M. Darnell, Benjamin L. Gaudio, Evan C. Lien, Anna M. Barbeau, Matthew G. Vander Heiden, Peter K. Sorger
Blocking the import of nutrients essential for cancer cell proliferation represents a therapeutic opportunity, but it is unclear which transporters to target. Here, we report a CRISPRi/a screening platform to systematically interrogate the contributi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6618061bbd101132cdf4a515ab80e86
https://doi.org/10.1101/2023.01.26.525375
https://doi.org/10.1101/2023.01.26.525375
Autor:
Kiera M. Sapp, Evan C. Lien, Allison N. Lau, Zhaoqi Li, Matthew G. Vander Heiden, Anna M. Westermark, Yin Zhang, Chen Yuan, Brian M. Wolpin
Publikováno v:
Nature
Dietary interventions can change metabolite levels in the tumour microenvironment, which might then affect cancer cell metabolism to alter tumour growth1–5. Although caloric restriction (CR) and a ketogenic diet (KD) are often thought to limit tumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::034a344f9f9255a46b3367455c764d70
https://doi.org/10.1038/s41586-021-04049-2
https://doi.org/10.1038/s41586-021-04049-2
Autor:
Zhaoqi Li, Brian W. Ji, Purushottam D. Dixit, Konstantine Tchourine, Evan C. Lien, Aaron M. Hosios, Keene L. Abbott, Justine C. Rutter, Anna M. Westermark, Elizabeth F. Gorodetsky, Lucas B. Sullivan, Matthew G. Vander Heiden, Dennis Vitkup
Publikováno v:
Nat Metab
Production of oxidized biomass, which requires regeneration of the cofactor NAD+, can be a proliferation bottleneck that is influenced by environmental conditions. However, a comprehensive quantitative understanding of metabolic processes that may be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::754ddc49204415185a466d4ae8b80af3
https://europepmc.org/articles/PMC10305743/
https://europepmc.org/articles/PMC10305743/
Autor:
Pei Zhou, Nimrat Chatterjee, Sophia M Min, Oliver Jonas, Graham C. Walker, Michael T. Hemann, Matthew G. Vander Heiden, Evan C. Lien, Matthew Whitman, Cynthia A. Harris, Alba Luengo, Jiyong Hong
Publikováno v:
Proc Natl Acad Sci U S A
REV1/POLζ-dependent mutagenic translesion synthesis (TLS) promotes cell survival after DNA damage but is responsible for most of the resulting mutations. A novel inhibitor of this pathway, JH-RE-06, promotes cisplatin efficacy in cancer cells and mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c7c722beb814c376f76b1eb101b6bda
https://doi.org/10.1073/pnas.2016064117
https://doi.org/10.1073/pnas.2016064117
Autor:
Victoire Gouirand, Tristan Gicquel, Evan C Lien, Emilie Jaune‐Pons, Quentin Da Costa, Pascal Finetti, Elodie Metay, Camille Duluc, Jared R Mayers, Stephane Audebert, Luc Camoin, Laurence Borge, Marion Rubis, Julie Leca, Jeremy Nigri, François Bertucci, Nelson Dusetti, Juan Lucio Iovanna, Richard Tomasini, Ghislain Bidaut, Fabienne Guillaumond, Matthew G Vander Heiden, Sophie Vasseur
Publikováno v:
EMBO Journal
EMBO Journal, 2022, ⟨10.15252/embj.2021110466⟩
The EMBO journal, vol 41, iss 9
EMBO J
EMBO Journal, 2022, ⟨10.15252/embj.2021110466⟩
The EMBO journal, vol 41, iss 9
EMBO J
Pancreatic ductal adenocarcinoma (PDA) tumor cells are deprived of oxygen and nutrients and therefore must adapt their metabolism to ensure proliferation. In some physiological states, cells rely on ketone bodies to satisfy their metabolic needs, esp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::402d390310382a7d2b9d332eef585cf9
https://hal-amu.archives-ouvertes.fr/hal-03623502
https://hal-amu.archives-ouvertes.fr/hal-03623502
Autor:
Matthew G. Vander Heiden, Evan C. Lien
Publikováno v:
Cell Metabolism. 33:702-704
The metabolism of nutrients other than glucose influences insulin secretion by pancreatic β cells, but the mechanisms involved are incompletely understood. In this issue of Cell Metabolism, Zhang et al. (2020) report that reductive glutamine metabol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c69daf53fb1cdf661a396b5fa7976a22
https://doi.org/10.1016/j.cmet.2021.03.010
https://doi.org/10.1016/j.cmet.2021.03.010
Autor:
Tiffany Tsang, Qingling He, Emily B. Cohen, Casey Stottrup, Evan C. Lien, Huiqi Zhang, C. Geoffrey Lau, Y. Rebecca Chin
Publikováno v:
Cancers; Volume 14; Issue 20; Pages: 5006
The PI3K/Akt pathway is frequently deregulated in human cancers, and multiple Akt inhibitors are currently under clinical evaluation. Based on the experience from other molecular targeted therapies, however, it is likely that acquired resistance will
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f69006b69a8a9ff192a24b70fe8671b9
https://doi.org/10.3390/cancers14205006
https://doi.org/10.3390/cancers14205006