Zobrazeno 1 - 10
of 150
pro vyhledávání: '"Evan A, Scott"'
Autor:
Eva Morgun, Jennifer Zhu, Sultan Almunif, Sharan Bobbala, Melissa S Aguilar, Junzhong Wang, Kathleen Conner, Yongyong Cui, Liang Cao, Chetan Seshadri, Evan A Scott, Chyung-Ru Wang
Publikováno v:
eLife, Vol 12 (2023)
Mycobacterium tuberculosis (Mtb) infection elicits both protein and lipid antigen-specific T cell responses. However, the incorporation of lipid antigens into subunit vaccine strategies and formulations has been underexplored, and the characteristics
Externí odkaz:
https://doaj.org/article/6b58467588cc497ca1e3645a884385c2
Autor:
Debora B. Scariot, Austeja Staneviciute, Jennifer Zhu, Xiaomo Li, Evan A. Scott, David M. Engman
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Nanotechnology is revolutionizing many sectors of science, from food preservation to healthcare to energy applications. Since 1995, when the first nanomedicines started being commercialized, drug developers have relied on nanotechnology to improve th
Externí odkaz:
https://doaj.org/article/ffadb00431674104804c4868d304f8a2
Autor:
Sijia Yi, Sun-Young Kim, Michael P. Vincent, Simseok A. Yuk, Sharan Bobbala, Fanfan Du, Evan Alexander Scott
Publikováno v:
iScience, Vol 25, Iss 7, Pp 104555- (2022)
Summary: Plasmid DNA (pDNA) transfection is advantageous for gene therapies requiring larger genetic elements, including “all-in-one” CRISPR/Cas9 plasmids, but is limited by toxicity as well as poor intracellular release and transfection efficien
Externí odkaz:
https://doaj.org/article/d432c22450994663a654c2b64e717126
Autor:
Michael P. Vincent, Sharan Bobbala, Nicholas B. Karabin, Molly Frey, Yugang Liu, Justin O. Navidzadeh, Trevor Stack, Evan A. Scott
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Polymeric nanocarriers used for drug delivery are often coated by albumin in vivo influencing the therapeutic outcomes. Here, the authors engineer the surface chemistry of a nanocarrier to either stabilize or denature the structure of adsorbed albumi
Externí odkaz:
https://doaj.org/article/15a179777f9c4b2e8d6492098d24f2b1
Autor:
Fanfan Du, Baofu Qiao, Trung Dac Nguyen, Michael P. Vincent, Sharan Bobbala, Sijia Yi, Chamille Lescott, Vinayak P. Dravid, Monica Olvera de la Cruz, Evan Alexander Scott
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Natural biomolecules such as peptides and DNA can dynamically self-organize into diverse hierarchical structures. Here the authors report experiments and simulations on the dynamic network self-assembly and subsequent collapse of the synthetic homopo
Externí odkaz:
https://doaj.org/article/64ac7fd9f98a4752983d43cca3a4d5d0
Publikováno v:
Advanced NanoBiomed Research, Vol 1, Iss 11, Pp n/a-n/a (2021)
Self‐assembling filomicelles (FMs) are of great interest to nanomedicine due to their structural flexibility, extensive systemic circulation time, and amenability to unique “cylinder‐to‐sphere” morphological transitions. However, current fa
Externí odkaz:
https://doaj.org/article/bbefe2efe0ec45d4a38159a6dfc54171
Autor:
Xiaomo Li, Sijia Yi, Débora B. Scariot, Santiago J. Martinez, Ben A. Falk, Cheryl L. Olson, Patricia S. Romano, Evan A. Scott, David M. Engman
Publikováno v:
JCI Insight, Vol 6, Iss 9 (2021)
Chagas disease is caused by infection with the protozoan parasite Trypanosoma cruzi (T. cruzi), an intracellular pathogen that causes significant morbidity and death among millions in the Americas from Canada to Argentina. Current therapy involves or
Externí odkaz:
https://doaj.org/article/740abbba4d284f08b4c84c047dc55ccd
Autor:
Sijia Yi, Nicholas B. Karabin, Jennifer Zhu, Sharan Bobbala, Huijue Lyu, Sophia Li, Yugang Liu, Molly Frey, Michael Vincent, Evan A. Scott
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
Chronic unresolved vascular inflammation is a critical factor in the development of atherosclerosis. Cardiovascular immunotherapy has therefore become a recent focus for treatment, with the objective to develop approaches that can suppress excessive
Externí odkaz:
https://doaj.org/article/3082ebaf7bad4308a990d1e3d5862a30
Autor:
Nicholas B. Karabin, Sean Allen, Ha-Kyung Kwon, Sharan Bobbala, Emre Firlar, Tolou Shokuhfar, Kenneth R. Shull, Evan A. Scott
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nanocarrier administration is often performed via intermittent bolus injection while sustained delivery platforms are rarely reported. Here the authors demonstrate that the cylinder-to-sphere transitions of self-assembled filomicelle scaffolds can be
Externí odkaz:
https://doaj.org/article/ce2bb2bc8ef841a2af53aed925aacee2
Autor:
Chamille Lescott, Sharan Bobbala, Mallika Modak, Roberto dos Reis, Evan A Scott, Vinayak P Dravid
Publikováno v:
Microscopy and Microanalysis. 29:16-26
Self-assembled polymer nanostructures are useful for many applications, including biomedicine, energy, and sensing, often presenting a more stable and customizable alternative for drug delivery than lipid-based assemblies, like liposomes. Polyethylen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b45aba4bc0c87fef5e6c415b0796e9e
https://doi.org/10.1093/micmic/ozac023
https://doi.org/10.1093/micmic/ozac023