HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment

Autor: Frank Buchholz, Clara Lopes Novo, J. Arturo Londoño-Vallejo, Michelle Stevense, Matthias Mann, Christian Benda, Dragomir B. Krastev, Claire Basquin, Rolf Jessberger, Irena Draskovic, Masatake Araki, Dennis Kappei, Kimi Araki, Marion Scheibe, Ralf Kittler, Falk Butter

Publikováno v: EMBO Journal, 32, 1681-701
The EMBO Journal
EMBO Journal, 32, 12, pp. 1681-701

Telomeres are repetitive DNA structures that, together with the shelterin and the CST complex, protect the ends of chromosomes. Telomere shortening is mitigated in stem and cancer cells through the de novo addition of telomeric repeats by telomerase.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aef4eaa41fb448b11d2515da09257fc8
https://hdl.handle.net/2066/125716

Significance of complete 1p/19q co-deletion, IDH1 mutation and MGMT promoter methylation in gliomas: use with caution

Autor: Albert J. Idema, Lindsey Heathcock, Anja Gijtenbeek, Sandra H.E. Boots-Sprenger, Fonnet E. Bleeker, Pieter Wesseling, Jos Rijntjes, Kristin Diefes, Andreana L. Rivera, Kenneth D. Aldape, Judith W. M. Jeuken, Bastiaan B J Tops, Angelique Sijben

Publikováno v: Modern Pathology, 26, 7, pp. 922-9
Modern pathology, 26(7), 922-929. Nature Publishing Group
Boots-Sprenger, S H E, Sijben, A, Rijntjes, J, Tops, B B J, Idema, A J, Rivera, A L, Bleeker, F E, Gijtenbeek, A M, Diefes, K, Heathcock, L, Aldape, K D, Jeuken, J W M & Wesseling, P 2013, ' Significance of complete 1p/19q co-deletion, IDH1 mutation and MGMT promoter methylation in gliomas: use with caution ', Modern Pathology, vol. 26, no. 7, pp. 922-929 . https://doi.org/10.1038/modpathol.2012.166
Modern Pathology, 26(7), 922-929. Nature Publishing Group
Modern Pathology, 26, 922-9

Item does not contain fulltext The histopathological diagnosis of diffuse gliomas often lacks the precision that is needed for tailored treatment of individual patients. Assessment of the molecular aberrations will probably allow more robust and prog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b76645d1afd6792c2b451a75467632a
https://doi.org/10.1038/modpathol.2012.166

Pattern of follow-up care and early relapse detection in breast cancer patients

Autor: Margriet van der Heiden-van der Loo, André L. M. Verbeek, Jos A.A.M. van Dijck, Femmie de Vegt, Sandra M. E. Geurts, Karin Flobbe, Vivianne C. G. Tjan-Heijnen, Katja K.H. Aben, Sabine Siesling

Publikováno v: Breast Cancer Research and Treatment; Vol 136
Breast Cancer Research and Treatment, 136, 859-68
Breast Cancer Research and Treatment
Breast Cancer Research and Treatment, 136, 3, pp. 859-68
Breast Cancer Research and Treatment, 136(3), 859-868. Springer, Cham
Breast cancer research and treatment, 136(3), 859-868. Springer

Item does not contain fulltext Routine breast cancer follow-up aims at detecting second primary breast cancers and loco regional recurrences preclinically. We studied breast cancer follow-up practice and mode of relapse detection during the first 5 y

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eea9db87213fe0ef979b9c79aa154cd
https://cris.maastrichtuniversity.nl/en/publications/46b41f05-cf7e-44b0-8e9f-72915d3916d9

Cancer in adolescents and young adults (15–29 years): A population-based study in the Netherlands 1989–2009

Autor: Gerhard A. Zielhuis, Katja K.H. Aben, Nienke A van Gils, Winette T. A. van der Graaf, J. Carlijn van Gaal

Publikováno v: Acta Oncologica, 51, 922-33
Acta Oncologica, 51, 7, pp. 922-33

Item does not contain fulltext Abstract Background. Cancer among adolescents and young adults (AYAs; 15-29 years old) is relatively rare but its incidence is increasing worldwide. To define the extent and nature of the AYA patients, this population-b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c910febbd50d0c37ff8b58ae1cf678b7
https://doi.org/10.3109/0284186x.2012.705891

Prognostic factors and survival in primary malignant astrocytomas of the spinal cord: a population-based analysis from 1973 to 2007

Autor: Hadie Adams, Ziya L. Gokaslan, Alfredo Quinones-Hinojosa, Javier Avendaño, Shaan M. Raza, George I. Jallo

Publikováno v: Spine, 37, 12, pp. E727-35
Spine, 37, E727-35

Item does not contain fulltext STUDY DESIGN: Observational cross-sectional study. OBJECTIVE: Using data from the population-based cancer registries of the Surveillance, Epidemiology and End Results (SEER) program, we analyzed demographic features, tu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::328b13b86f3e6a5cf16ad7c5163f7a12
https://doi.org/10.1097/brs.0b013e31824584c0