Persistent systemic inflammation is associated with poor clinical outcomes in COPD: a novel phenotype.

Autor: Alvar Agustí, Lisa D Edwards, Stephen I Rennard, William MacNee, Ruth Tal-Singer, Bruce E Miller, Jørgen Vestbo, David A Lomas, Peter M A Calverley, Emiel Wouters, Courtney Crim, Julie C Yates, Edwin K Silverman, Harvey O Coxson, Per Bakke, Ruth J Mayer, Bartolome Celli, Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators

Publikováno v: PLoS ONE, Vol 7, Iss 5, p e37483 (2012)

Because chronic obstructive pulmonary disease (COPD) is a heterogeneous condition, the identification of specific clinical phenotypes is key to developing more effective therapies. To explore if the persistence of systemic inflammation is associated

Externí odkaz: https://doaj.org/article/7cf85a7a11e44db19f9eaf7ef5f936ff

Association Between Interstitial Lung Abnormalities and All-Cause Mortality

Autor: Putman, Rachel K, Hatabu, Hiroto, Araki, Tetsuro, Gudmundsson, Gunnar, Gao, Wei, Nishino, Mizuki, Okajima, Yuka, Dupuis, Josée, Latourelle, Jeanne C, Cho, Michael H, El-Chemaly, Souheil, Coxson, Harvey O, Celli, Bartolome R, Fernandez, Isis E, Zazueta, Oscar E, Ross, James C, Harmouche, Rola, Estépar, Raúl San José, Diaz, Alejandro A, Sigurdsson, Sigurdur, Gudmundsson, Elías F, Eiríksdottír, Gudny, Aspelund, Thor, Budoff, Matthew J, Kinney, Gregory L, Hokanson, John E, Williams, Michelle C, Murchison, John T, MacNee, William, Hoffmann, Udo, O'Donnell, Christopher J, Launer, Lenore J, Harrris, Tamara B, Gudnason, Vilmundur, Silverman, Edwin K, O'Connor, George T, Washko, George R, Rosas, Ivan O, Hunninghake, Gary M, Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators, COPDGene Investigators

Publikováno v: JAMA, vol 315, iss 7
Putman, RK; Hatabu, H; Araki, T; Gudmundsson, G; Gao, W; Nishino, M; et al.(2016). Association Between Interstitial Lung Abnormalities and All-Cause Mortality. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 315(7), 672-681. doi: 10.1001/jama.2016.0518. UCLA: Retrieved from: http://www.escholarship.org/uc/item/6g101927

ImportanceInterstitial lung abnormalities have been associated with lower 6-minute walk distance, diffusion capacity for carbon monoxide, and total lung capacity. However, to our knowledge, an association with mortality has not been previously invest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::466c9294520b1b0103ed2190f4b9e661
https://escholarship.org/uc/item/6g101927

Coronary artery calcification is increased in patients with COPD and associated with increased morbidity and mortality

Autor: Williams, M.C., Murchison, J.T., Edwards, L.D., Agusti, A., Bakke, P., Calverley, P.M.A., Celli, B., Coxson, H.O., Crim, C., Lomas, D.A., Miller, B.E., Rennard, S., Silverman, E.K., Tal Singer, R., Vestbo, J., Wouters, E., Yates, J.C., van Beek, E.J.R, Newby, D.E., Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) investigators, the, MacNee, W.

Publikováno v: Thorax, 69(8), 718-723. BMJ Publishing Group
Williams, M C, Murchison, J T, Edwards, L D, Agusti, A, Bakke, P, Calverley, P M A, Celli, B, Coxson, H O, Crim, C, Lomas, D A, Miller, B E, Rennard, S, Silverman, E K, Tal-Singer, R, Vestbo, J, Wouters, E, Yates, J C, Van Beek, E J R, Newby, D E, MacNee, W & Evaluation, C L 2014, ' Coronary artery calcification is increased in patients with COPD and associated with increased morbidity and mortality ', Thorax, vol. 69, no. 8, pp. 718-723 . https://doi.org/10.1136/thoraxjnl-2012-203151

Background Coronary artery calcification is pathognomonic of coronary artery disease (CAD). Whether CAD in patients with COPD is linked to lung function, functional capacity and/or clinically relevant outcomes is unknown. The objective was to assess

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fa756aaaac81cc3c336da7a5cea704e
https://cris.maastrichtuniversity.nl/en/publications/31921aa5-fba7-4110-9649-54e73d989f23

Common Genetic Variants Associated with Resting Oxygenation in Chronic Obstructive Pulmonary Disease

Autor: McDonald, M.L.N., Cho, M.H., Sorheim, I.C., Lutz, S.M., Castaldi, P.J., Lomas, D.A., Coxson, H.O., Edwards, L.D., MacNee, W., Vestbo, J., Yates, J.C., Agusti, A., Calverley, P.M.A., Celli, B., Crim, C., Rennard, S.I., Wouters, E.F.M., Bakke, P., Tal-Singer, R., Miller, B.E., Gulsvik, A., Casaburi, R., Wells, J.M., Regan, E.A., Make, B.J., Hokanson, J.E., Lange, C., Crapo, J.D., Beaty, T.H., Silverman, E.K., Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints, the, COPDGene Investigators, the, Hersh, C.P.

Publikováno v: American Journal of Respiratory Cell and Molecular Biology, 51(5), 678-687. American Thoracic Society
McDonald, M-L N, Cho, M H, Sørheim, I-C, Lutz, S M, Castaldi, P J, Lomas, D A, Coxson, H O, Edwards, L D, MacNee, W, Vestbo, J, Yates, J C, Agusti, A, Calverley, P M A, Celli, B, Crim, C, Rennard, S I, Wouters, E F M, Bakke, P, Tal-Singer, R, Miller, B E, Gulsvik, A, Casaburi, R, Wells, J M, Regan, E A, Make, B J, Hokanson, J E, Lange, C, Crapo, J D, Beaty, T H, Silverman, E K, Hersh, C P, Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints and COPDGene Investigators & Mattheisen, M 2014, ' Common genetic variants associated with resting oxygenation in chronic obstructive pulmonary disease ' American Journal of Respiratory Cell and Molecular Biology (Online), vol. 51, no. 5, pp. 678-87 . https://doi.org/10.1165/rcmb.2014-0135OC
American journal of respiratory cell and molecular biology, vol 51, iss 5

Hypoxemia is a major complication of chronic obstructive pulmonary disease (COPD) that correlates with disease prognosis. Identifying genetic variants associated with oxygenation may provide clues for deciphering the heterogeneity in prognosis among

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a6b85c0cf42a2fe921db7675dd59c4d
https://cris.maastrichtuniversity.nl/en/publications/4927b6a8-a84b-4d93-9586-839cf22b3a20

Quantifying the extent of emphysema: factors associated with radiologists' estimations and quantitative indices of emphysema severity using the ECLIPSE cohort.

Autor: Gietema HA, Müller NL, Fauerbach PV, Sharma S, Edwards LD, Camp PG, Coxson HO, Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) investigators, Gietema, Hester A, Müller, Nestor L, Fauerbach, Paola V Nasute, Sharma, Sanjay, Edwards, Lisa D, Camp, Pat G, Coxson, Harvey O

Publikováno v: Academic Radiology; Jun2011, Vol. 18 Issue 6, p661-671, 11p