Cardiac cell therapy: overexpression of connexin43 in skeletal myoblasts and prevention of ventricular arrhythmias.: Cardiac cell and Cx43-gene therapy for arrhythmias

Autor: Fernandes, Sarah, Van Rijen, Harold, Forest, Virginie, Evain, Stéphane, Leblond, Anne-Laure, Mérot, Jean, Charpentier, Flavien, De Bakker, Jacques, Lemarchand, Patricia

Publikováno v: Journal of Cellular and Molecular Medicine
Journal of Cellular and Molecular Medicine, Wiley Open Access, 2009, 13 (9B), pp.3703-12. ⟨10.1111/j.1582-4934.2009.00740.x⟩

International audience; Cell-based therapies have great potential for the treatment of cardiovascular diseases. Recently, using a transgenic mouse model Roell et al. reported that cardiac engraftment of connexin43 (Cx43)-overexpressing myoblasts in v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::0ede8e9445b4442a840d7787332187ed
https://www.hal.inserm.fr/inserm-00369695

0257: Genetic inactivation of Kir3.4 (GIRK4) channels improves heart rate and abolishes atrial tachyarrhythmias in a mouse model of sick-sinus syndrome

Autor: Mesirca, Pietro, Lequang, Khai, Torrente, Angelo G., Marger, Laurine, Leoni, Anne Laure, Briec, François, Evain, Stéphane, Nargeot, Joel, Striessnig, Joerg, Wickman, Kevin, Charpentier, Flavien, Mangoni, Matteo E.

Publikováno v: In Archives of Cardiovascular Diseases Supplements April 2014 6 Supplement 1:33-33

G protein-gated IKACh channels as therapeutic targets for treatment of sick sinus syndrome and heart block.

Autor: Mesirca P; Département de Physiologie, Institut de Genomique Fonctionnelle, Laboratory of Excellence in Ion Channel Science and Therapeutics, UMR-5203, CNRS, F-34094 Montpellier, France; INSERM U661, F-34094 Montpellier, France; Université de Montpellier, F-34094 Montpellier, France; pietro.mesirca@igf.cnrs.fr matteo.mangoni@igf.cnrs.fr., Bidaud I; Département de Physiologie, Institut de Genomique Fonctionnelle, Laboratory of Excellence in Ion Channel Science and Therapeutics, UMR-5203, CNRS, F-34094 Montpellier, France; INSERM U661, F-34094 Montpellier, France; Université de Montpellier, F-34094 Montpellier, France;, Briec F; INSERM, UMR_S1087, l'Institut du Thorax, F-44007 Nantes, France;, Evain S; INSERM, UMR_S1087, l'Institut du Thorax, F-44007 Nantes, France;, Torrente AG; Département de Physiologie, Institut de Genomique Fonctionnelle, Laboratory of Excellence in Ion Channel Science and Therapeutics, UMR-5203, CNRS, F-34094 Montpellier, France; INSERM U661, F-34094 Montpellier, France; Université de Montpellier, F-34094 Montpellier, France;, Le Quang K; INSERM, UMR_S1087, l'Institut du Thorax, F-44007 Nantes, France; Université de Nantes, F-44007 Nantes, France;, Leoni AL; INSERM U661, F-34094 Montpellier, France;, Baudot M; Département de Physiologie, Institut de Genomique Fonctionnelle, Laboratory of Excellence in Ion Channel Science and Therapeutics, UMR-5203, CNRS, F-34094 Montpellier, France; INSERM U661, F-34094 Montpellier, France; Université de Montpellier, F-34094 Montpellier, France;, Marger L; Département de Physiologie, Institut de Genomique Fonctionnelle, Laboratory of Excellence in Ion Channel Science and Therapeutics, UMR-5203, CNRS, F-34094 Montpellier, France; INSERM U661, F-34094 Montpellier, France; Université de Montpellier, F-34094 Montpellier, France;, Chung You Chong A; Département de Physiologie, Institut de Genomique Fonctionnelle, Laboratory of Excellence in Ion Channel Science and Therapeutics, UMR-5203, CNRS, F-34094 Montpellier, France; INSERM U661, F-34094 Montpellier, France; Université de Montpellier, F-34094 Montpellier, France;, Nargeot J; Département de Physiologie, Institut de Genomique Fonctionnelle, Laboratory of Excellence in Ion Channel Science and Therapeutics, UMR-5203, CNRS, F-34094 Montpellier, France; INSERM U661, F-34094 Montpellier, France; Université de Montpellier, F-34094 Montpellier, France;, Striessnig J; Institute of Pharmacy, Pharmacology and Toxicology and Center of Molecular Biosciences Innsbruck, A-6020 Innsbruck, Austria;, Wickman K; Department of Pharmacology, University of Minnesota, Minneapolis, MN 554557;, Charpentier F; INSERM, UMR_S1087, l'Institut du Thorax, F-44007 Nantes, France; Université de Nantes, F-44007 Nantes, France; CNRS UMR 6291, l'Institut du Thorax, F-44007 Nantes, France; Centre Hospitalier Universitaire Nantes, F-44007 Nantes, France., Mangoni ME; Département de Physiologie, Institut de Genomique Fonctionnelle, Laboratory of Excellence in Ion Channel Science and Therapeutics, UMR-5203, CNRS, F-34094 Montpellier, France; INSERM U661, F-34094 Montpellier, France; Université de Montpellier, F-34094 Montpellier, France; pietro.mesirca@igf.cnrs.fr matteo.mangoni@igf.cnrs.fr.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2016 Feb 16; Vol. 113 (7), pp. E932-41. Date of Electronic Publication: 2016 Feb 01.