Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Evaggelia S Arsenou"'
Autor:
D.O. Onyango, S.S. Nikolaropoulos, Anna I. Koutsourea, Athanasios A. Papageorgiou, Evaggelia S. Arsenou, Dionysios Mourelatos, Manolis A. Fousteris, E. Karaberis
Publikováno v:
Chemotherapy. 53:118-126
Combination chemotherapy is widely and routinely used for most cancer patients. The main objective of this study is an effort to develop new anticancer drugs and procedures with enhanced antitumor activity and reduced toxicity. This study was designe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e303de94dae7f47041964b4fa1695e1f
https://doi.org/10.1159/000099983
https://doi.org/10.1159/000099983
Autor:
Manolis A. Fousteris, Evaggelia S. Arsenou, Anna I. Koutsourea, S.S. Nikolaropoulos, Dionysios Mourelatos, N. P. Lagonikakos, C. Spyridonidou
Publikováno v:
Medicinal Chemistry. 2:569-576
Recent studies have indicated that minor functional changes on the steroidal part of complex molecules, comprising of an alkylating moiety and a steroidal congener, lead to compounds with enhanced biological activity. The observed induction of the ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75f207f3a8c00578357432b05e8b6569
https://doi.org/10.2174/1573406410602060569
https://doi.org/10.2174/1573406410602060569
Autor:
Manolis A. Fousteris, Zafiria Iakovidou, E. Mioglou, Sotiris S. Nikolaropoulos, Athanasios A. Papageorgiou, Dionysios Mourelatos, Evaggelia S. Arsenou, Anna I. Koutsourea, Venetia Karayianni
Publikováno v:
Anti-Cancer Drugs. 15:983-990
We have investigated the role of the allylic 7-ketone in oxidized Delta5-steroids on antileukemic activity. We synthesized and studied a series of oxidized and non-oxidized steroidal esters of p-N,N-bis(2-chloroethyl)aminophenylacetic acid (PHE), chl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36c6714eb43d706f03fbf8c7b9dd82cb
https://doi.org/10.1097/00001813-200411000-00008
https://doi.org/10.1097/00001813-200411000-00008
Autor:
Evaggelia S. Arsenou, L. Leondiadis, Manolis A. Fousteris, Anna I. Koutsourea, Ioannis K. Stamos, Sotiris S. Nikolaropoulos
Publikováno v:
Journal of Heterocyclic Chemistry. 41:349-353
The synthesis of seven pyrrolo[2,3-a]carbazoles derivatives using Fischer indole cyclization conditions is described. Polyphosphoric acid trimethylsilyl ester was used as a mild catalyst for the cyclization step of intermediate arylhydrazones which w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::081966b8c9b7af6208caaae0842f75e9
https://doi.org/10.1002/jhet.5570410307
https://doi.org/10.1002/jhet.5570410307
Publikováno v:
Mini-Reviews in Medicinal Chemistry. 3:557-567
7-keto-Delta(5)-steroids have been suggested for the treatment of several diseases. Their significant biological profile resulted in the development of a great number of methods and reagents for the allylic oxidation of Delta(5)-steroids. These metho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6594fd2457c07cdf5efd63b57d33ba9f
https://doi.org/10.2174/1389557033487953
https://doi.org/10.2174/1389557033487953
Publikováno v:
Steroids. 68:659-666
A new synthetic procedure and a modification of the original method described in the literature for the synthesis of the steroidal B-D bilactam, 3 beta-hydroxy-7 alpha,17 alpha-diaza-B,D-dihomo-5-androsten-7,17-dione are reported. The key step in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7d72c00a056a23b44d473390f06a4fd
https://doi.org/10.1016/s0039-128x(03)00095-3
https://doi.org/10.1016/s0039-128x(03)00095-3
Publikováno v:
Steroids. 68:407-414
A variety of delta5-steroids were converted into alpha, beta-unsaturated 7-ketones using a modification of the already known method of t-butyl hydroperoxide in the presence of copper iodide in acetonitrile. The same alteration was applied to another
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b7f3d29f175225991478a18a609284e
https://doi.org/10.1016/s0039-128x(03)00042-4
https://doi.org/10.1016/s0039-128x(03)00042-4
Autor:
Sotiris S. Nikolaropoulos, E. Mioglou, Venetia Karayianni, Manolis A. Fousteris, Anna I. Koutsourea, Z. Iakovidou, Evaggelia S. Arsenou, Dionysios Mourelatos
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 535:79-86
Three newly synthesised steroidal esteric derivatives of nitrogen mustard (compounds 1 – 3 ) were comparatively studied on a molar basis regarding their ability to induce sister chromatid exchanges (SCEs) in normal human lymphocytes in vitro and th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::379beea86b5ba89b8eb2659e26fd5e49
https://doi.org/10.1016/s1383-5718(02)00286-3
https://doi.org/10.1016/s1383-5718(02)00286-3
Autor:
E. Chryssogelou, Sotiris S. Nikolaropoulos, A. Kotsis, Dionysios Mourelatos, Evaggelia S. Arsenou, Athanasios A. Papageorgiou, E. Karaberis
Publikováno v:
Chemotherapy. 45:61-67
The authors studied the effect of two modified steroids containing different proportions (%) of alkylating agents alone or in combination on sister chromatid exchange (SCE) rates and on human lymphocyte proliferation kinetics. The antitumor activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c984ae5b3a1692f26fd6d6acb9a76b53
https://doi.org/10.1159/000007166
https://doi.org/10.1159/000007166
Autor:
Manolis A. Fousteris, Evaggelia S. Arsenou, Dionysios Mourelatos, Anna I. Koutsourea, Sotiris S. Nikolaropoulos, Athanasios A. Papageorgiou
Publikováno v:
Anti-cancer drugs. 17(5)
In order to study the role of the steroidal moiety on the expression of anti-leukemic activity, we synthesized six derivatives of chlorambucil (CHL), and tested them on leukemias P388 and L1210 in vivo and in normal human lymphocytes in vitro. Five o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8267bc0593c6f2b466bcf1b8e39de8a6
https://pubmed.ncbi.nlm.nih.gov/16702807
https://pubmed.ncbi.nlm.nih.gov/16702807