Výsledky vyhledávání - "Eva-Maria Materne"

A P19 and P19CL6 Cell-Based Complementary Approach to Determine Paracrine Effects in Cardiac Tissue Engineering

Autor: Eva-Maria Materne, Jochen Ringe, Michael Sittinger, Tilo Dehne, Sophie Van Linthout, Marion Haag, Jan Philipp Krüger, Carsten Tschöpe, Xavier Adam, Mareike Carola Reimann

Publikováno v: Cells Tissues Organs. 199:24-36

The negligible self-repair potential of the myocardium has led to cell-based tissue engineering approaches to restore heart function. There is more and more consensus that, in addition to cell development, paracrine effects in particular play a pivot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::115259b21d5252fd24c3552e149d749c
https://doi.org/10.1159/000362540

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The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture

Autor: Alexandra Lorenz, Ilka Maschmeyer, Mathias Busek, Katharina Schimek, Roland Lauster, Uwe Marx, Eva-Maria Materne, Reyk Horland, Frank Sonntag

Publikováno v: Journal of Visualized Experiments : JoVE

The ever growing amount of new substances released onto the market and the limited predictability of current in vitro test systems has led to a high need for new solutions for substance testing. Many drugs that have been removed from the market due t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca4b5e14f782b0c37965b916e9aeabb4
https://doi.org/10.3791/52526-v

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Chip-based human liver-intestine and liver-skin co-cultures--A first step toward systemic repeated dose substance testing in vitro

Autor: Annika Jaenicke, Ilka Maschmeyer, Tobias Hasenberg, Uwe Marx, Frank Sonntag, Leif-Alexander Garbe, Julie Zech, Patrick Hayden, Marcus Lindner, Seyoum Ayehunie, Eva-Maria Materne, Roland Lauster, Alexandra Lorenz

Publikováno v: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 95

Systemic repeated dose safety assessment and systemic efficacy evaluation of substances are currently carried out on laboratory animals and in humans due to the lack of predictive alternatives. Relevant international regulations, such as OECD and ICH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41fb7c09252924a205db94620da93dff
https://pubmed.ncbi.nlm.nih.gov/25857839

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Chip-based liver equivalents for toxicity testing - organotypicalness versus cost-efficient high throughput

Autor: Eva-Maria Materne, Uwe Marx, Alexander G. Tonevitsky

Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. Nationallizenz frei zugänglich. This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f81ece18ab9972f51cb999fcb2c2320
http://depositonce.tu-berlin.de/handle/11303/5642

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Assessment of troglitazone induced liver toxicity in a dynamically perfused two-organ Micro-Bioreactor system

Autor: Mathias Busek, Alexandra Lorenz, Caroline Frädrich, Udo Klotzbach, Roland Lauster, Reyk Horland, Silke Hoffmann, Uwe Marx, Eva-Maria Materne, Frank Sonntag, Ilka Wagner, Sven Brincker

Publikováno v: BMC Proceedings

Background The ever-growing amount of new substances released to the market and the limited predictability of current in vitro test systems has led to an ample need for new substance testing solutions. Many drugs like troglitazone, that had to be rem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af56ced8d80227249744272c5bf83603
http://europepmc.org/articles/PMC3980301

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Aspects of vascularization in Multi-Organ-Chips

Autor: Silke Hoffmann, Alexandra Lorenz, Reyk Horland, Udo Klotzbach, Frank Sonntag, Gerd Lindner, Ulrike Menzel, Ilka Wagner, Uwe Marx, Benjamin Groth, Mathias Busek, Roland Lauster, Sven Brincker, Katharina Schimek, Eva-Maria Materne

Publikováno v: BMC Proceedings

Background Enormous efforts have been made to develop circulation systems for physiological nutrient supply and waste removal of in vitro cultured tissues. These developments are aiming for in vitro generation of organ equivalents such as liver, lymp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::046434b5700d297547d11dd1612a941a
http://europepmc.org/articles/PMC3980705

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A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture

Autor: Alexander G. Tonevitsky, Mathias Busek, Sven Brincker, Ute Süßbier, Frank Sonntag, Ilka Wagner, E. V. Trushkin, Uwe Marx, Caroline Frädrich, Eva-Maria Materne, Roland Lauster, D. A. Sakharov

Publikováno v: Lab on a Chip. 13:3538

Current in vitro and animal tests for drug development are failing to emulate the systemic organ complexity of the human body and, therefore, to accurately predict drug toxicity. In this study, we present a multi-organ-chip capable of maintaining 3D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::040356b3af2ea029f6d4aaba776e4b1b
https://doi.org/10.1039/c3lc50234a

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