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Autor:
Lars Weidolf, Eva-Henriette Bangur, Gunnar Gronberg, Neal Castagnoli, Xue-Qing Li, Martin A. Hayes
Publikováno v:
Drug Metabolism and Disposition. 47:1247-1256
AZD1979 [(3-(4-(2-oxa-6-azaspiro[3.3]heptan-6-ylmethyl)phenoxy)azetidin-1-yl)(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)methanone] is a melanin-concentrating hormone receptor 1 antagonist designed for the treatment of obesity. In this study, metabolit