SAXS and stability studies of iron-induced oligomers of bacterial frataxin CyaY.

Autor: Mostafa Fekry, Wessen Alshokry, Przemysław Grela, Marek Tchórzewski, Eva-Christina Ahlgren, Christopher A Söderberg, Oleksandr Gakh, Grazia Isaya, Salam Al-Karadaghi

Publikováno v: PLoS ONE, Vol 12, Iss 9, p e0184961 (2017)

Frataxin is a highly conserved protein found in both prokaryotes and eukaryotes. It is involved in several central functions in cells, which include iron delivery to biochemical processes, such as heme synthesis, assembly of iron-sulfur clusters (ISC

Externí odkaz: https://doaj.org/article/276fdaea55a847fbbeb8f205105b7a57

Architecture of the Human Mitochondrial Iron-Sulfur Cluster Assembly Machinery

Autor: Oleksandr Gakh, Wasantha Ranatunga, Eva-Christina Ahlgren, Douglas Y. Smith, James R. Thompson, Grazia Isaya, Salam Al-Karadaghi

Publikováno v: Journal of Biological Chemistry. 291:21296-21321

Fe-S clusters, essential cofactors needed for the activity of many different enzymes, are assembled by conserved protein machineries inside bacteria and mitochondria. As the architecture of the human machinery remains undefined, we co-expressed in Es

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfac91c33ef787f47c2ad7c70ee56901
https://doi.org/10.1074/jbc.m116.738542

Iron-induced oligomerization of human FXN81-210 and bacterial CyaY frataxin and the effect of iron chelators

Autor: Grazia Isaya, Christopher A. G. Söderberg, Katja Bernfur, Salam Al-Karadaghi, Mostafa Fekry, Peter Højrup, Mathias Wiemann, Cecilia Emanuelsson, Olex Gakh, Morten Rasmussen, Eva-Christina Ahlgren

Publikováno v: PLoS ONE, Vol 12, Iss 12, p e0188937 (2017)
PLoS ONE
Ahlgren, E C, Fekry, M, Wiemann, M, Söderberg, C A, Bernfur, K, Gakh, O, Rasmussen, M, Højrup, P, Emanuelsson, C, Isaya, G & Al-Karadaghi, S 2017, ' Iron-induced oligomerization of human FXN 81-210 and bacterial CyaY frataxin and the effect of iron chelators ', PLOS ONE, vol. 12, no. 12, e0188937 . https://doi.org/10.1371/journal.pone.0188937

Patients suffering from the progressive neurodegenerative disease Friedreich’s ataxia have reduced expression levels of the protein frataxin. Three major isoforms of human frataxin have been identified, FXN42-210, FXN56-210 and FXN81-210, of which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fab1be055569c2df5983d894c6495308
http://europepmc.org/articles/PMC5714350?pdf=render

The Molecular Basis of Iron-induced Oligomerization of Frataxin and the Role of the Ferroxidation Reaction in Oligomerization*

Autor: Susanne Schaefer, Grazia Isaya, Oleksandr Gakh, Eva-Christina Ahlgren, Aleksander V. Shkumatov, Sreekanth Rajan, Christopher A. G. Söderberg, Dmitri I. Svergun, Salam Al-Karadaghi

Publikováno v: Journal of Biological Chemistry
ICT FP7 Publications Database
OpenAIRE
Europe PubMed Central

The role of the mitochondrial protein frataxin in iron storage and detoxification, iron delivery to iron-sulfur cluster biosynthesis, heme biosynthesis, and aconitase repair has been extensively studied during the last decade. However, still no gener

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d69e6d54c6660c23ca6dea7ef34d7a37