Perforin Promotes Amyloid Beta Internalisation in Neurons

Autor: Erica Lana, Elisabet Åkesson, Charline Degavre, Evren Alici, Bengt Winblad, Homira Behbahani, Christina Unger Lithner, Eva-Britt Samuelsson, Mahbod Khanbolouki

Publikováno v: Molecular Neurobiology. 54:874-887

Studies on the mechanisms of neuronal amyloid-β (Aβ) internalisation are crucial for understanding the neuropathological progression of Alzheimer's disease (AD). We here investigated how extracellular Aβ peptides are internalised and focused on th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bb7185fea88030c9f3e8ba5fdb7a0ee
https://doi.org/10.1007/s12035-016-9685-9

MAP1B binds to the NMDA receptor subunit NR3A and affects NR3A protein concentrations

Autor: Erik Sundström, Eirikur Benedikz, Stefan Björklund, Elena Tortosa, Maria Eriksson, Jesús Avila, Helena Samuelsson, Eva-Britt Samuelsson

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Incorporation of the N-methyl-d-aspartate receptor (NMDAR) subunit NR3A into functional NMDARs results in reduced channel conductance and Ca2+ permeability. To further investigate the function of NR3A, we have set out to characterize its intracellula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f0ad3b75ebcccdfe34d5f12c5d409f0
https://doi.org/10.1016/j.neulet.2010.03.039

Analysis of NR3A receptor subunits in human native NMDA receptors

Autor: Eirikur Benedikz, Maria Eriksson, Elisabet Åkesson, Nenad Bogdanovic, E. Chris Muly, Erik Sundström, Anna Nilsson, Eva-Britt Samuelsson

Publikováno v: Nilsson, A, Eriksson, M, Muly, E C, Akesson, E, Samuelsson, E-B, Bogdanovic, N, Benedikz, E & Sundström, E 2007, ' Analysis of NR3A receptor subunits in human native NMDA receptors ', Brain Research, vol. 1186, pp. 102-12 . https://doi.org/10.1016/j.brainres.2007.09.008

NR3A, representing the third class of NMDA receptor subunits, was first studied in rats, demonstrating ubiquitous expression in the developing central nervous system (CNS), but in the adult mainly expressed in spinal cord and some forebrain nuclei. S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e79320c0e3815e3794d7450ba7638686
https://doi.org/10.1016/j.brainres.2007.09.008

On the role of NR3A in human NMDA receptors

Autor: Maria Eriksson, Elisabet Åkesson, Li-Li Mo, Helena Samuelsson, Anna Nilsson, Eirikur Benedikz, Erik Sundström, Eva-Britt Samuelsson

Publikováno v: Eriksson, M, Nilsson, A, Samuelsson, H, Samuelsson, E-B, Mo, L, Akesson, E, Benedikz, E & Sundström, E 2007, ' On the role of NR3A in human NMDA receptors ', Physiology & Behavior, vol. 92, no. 1-2, pp. 54-9 . https://doi.org/10.1016/j.physbeh.2007.05.026

In the present paper we describe our on-going project investigating the functional roles of the N-methyl-D-aspartate (NMDA) receptor subunit NR3A. We find that NR3A mRNA is abundant both in embryonic and adult human brain, in contrast to the almost n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea9f3735d6e7158808e62e231a278f03
https://doi.org/10.1016/j.physbeh.2007.05.026

Presenilin expression during induced differentiation of the human neuroblastoma SH-SY5Y cell line

Autor: Erik Sundström, Eva-Britt Samuelsson, Richard F. Cowburn, Åke Seiger, Fiona Flood, Janet A. Johnston, Birgitta Wiehager

Publikováno v: Neurochemistry International. 44:487-496

Human neuroblastoma SH-SY5Y cells stably transfected with both wild-type and exon-9 deleted (deltaE9) presenilin constructs were used to study the role of the presenilin proteins during differentiation. Cells transfected with either wild-type or delt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26644371508122c38f33e0b923eb6e0c
https://doi.org/10.1016/j.neuint.2003.09.002