Phenylephrine impairs host defence mechanisms to infection: a combined laboratory study in mice and translational human study

Autor: Henk J. van Leeuwen, Roeland F. Stolk, Roel Schambergen, Antonius E. van Herwaarden, Hans van der Hoeven, Joost Schouwstra, Mike Marvin Ruth, Matthijs Kox, Eva van der Pasch, Flavia Naumann, Steffi Bressers, Jelle Gerretsen, Peter Pickkers

Publikováno v: British Journal of Anaesthesia, 126, 652-664
British Journal of Anaesthesia, 126, 3, pp. 652-664

Background Immunosuppression after surgery is associated with postoperative complications, mediated in part by catecholamines that exert anti-inflammatory effects via the β-adrenergic receptor. Phenylephrine, generally regarded as a selective α-adr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4113eb6ee51f88248a6ef7db59eafabd
https://doi.org/10.1016/j.bja.2020.11.040

The effect of BCG vaccination on alveolar macrophages obtained from induced sputum from healthy volunteers

Autor: Nina Idh, Simone J.C.F.M. Moorlag, Isadore Budnick, L. Charlotte J. de Bree, Reinout van Crevel, Valerie A. C. M. Koeken, Vera P. Mourits, Matthijs Kox, Guus P. Leijte, Maria Lerm, Arjan van Laarhoven, Mihai G. Netea, Eva van der Pasch

Publikováno v: Cytokine
Cytokine, 133
Koeken, V A C M, van der Pasch, E S, Leijte, G P, Mourits, V P, de Bree, L C J, Moorlag, S J C F M, Budnick, I, Idh, N, Lerm, M, Kox, M, van Laarhoven, A, Netea, M G & van Crevel, R 2020, ' The effect of BCG vaccination on alveolar macrophages obtained from induced sputum from healthy volunteers ', Cytokine, vol. 133, 155135 . https://doi.org/10.1016/j.cyto.2020.155135

The anti-tuberculosis vaccine Bacillus Calmette-Guérin (BCG) is able to boost innate immune responses through a process called ‘trained immunity’. It is hypothesized that BCG-induced trained immunity contributes to protection against Mycobacteri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c39ef58270ed89bf025694ff95cec7eb
https://pubmed.ncbi.nlm.nih.gov/32534356

Tissue Metabolic Changes Drive Cytokine Responses to Mycobacterium tuberculosis

Autor: Ekta, Lachmandas, Ana B, Rios-Miguel, Valerie A C M, Koeken, Eva, van der Pasch, Vinod, Kumar, Vasiliki, Matzaraki, Yang, Li, Marije, Oosting, Leo A B, Joosten, Richard A, Notebaart, Mahdad, Noursadeghi, Mihai G, Netea, Reinout, van Crevel, Gabriele, Pollara

Publikováno v: The Journal of Infectious Diseases

Our study reveals that human tissue challenged with mycobacterial antigens induces differential expression of genes that regulate multiple metabolic pathways. We demonstrate that variable expression of these metabolic genes influences the cytokine re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ec1ad2d767f6baeba2a79f5670a786dd
https://pubmed.ncbi.nlm.nih.gov/29618104