MEG8 regulates Tissue Factor Pathway Inhibitor 2 (TFPI2) expression in the endothelium

Autor: Veerle Kremer, Diewertje I. Bink, Laura Stanicek, Eva van Ingen, Theresa Gimbel, Sarah Hilderink, Stefan Günther, Anne Yaël Nossent, Reinier A. Boon

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)

Abstract A large portion of the genome is transcribed into non-coding RNA, which does not encode protein. Many long non-coding RNAs (lncRNAs) have been shown to be involved in important regulatory processes such as genomic imprinting and chromatin mo

Externí odkaz: https://doaj.org/article/3bc5639ebbcb4d0fa042463c3214f86d

Adenosine-to-Inosine Editing of Vasoactive MicroRNAs Alters Their Targetome and Function in Ischemia

Autor: Reginald V.C.T. van der Kwast, Laura Parma, M. Leontien van der Bent, Eva van Ingen, Fabiana Baganha, Hendrika A.B. Peters, Eveline A.C. Goossens, Karin H. Simons, Meindert Palmen, Margreet R. de Vries, Paul H.A. Quax, A. Yaël Nossent

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 21, Iss , Pp 932-953 (2020)

Adenosine-to-inosine (A-to-I) editing in the seed sequence of microRNAs can shift the microRNAs’ targetomes and thus their function. Using public RNA-sequencing data, we identified 35 vasoactive microRNAs that are A-to-I edited. We quantified A-to-

Externí odkaz: https://doaj.org/article/2209272f4f534aa0b0f07a3770ab3c50

C/D box snoRNA SNORD113-6/AF357425 plays a dual role in integrin signalling and arterial fibroblast function via pre-mRNA processing and 2'O-ribose methylation

Autor: M. Leontien van der Bent, Hailiang Mei, Reinier A. Boon, Daphne A L van den Homberg, Paul H.A. Quax, Johann Wojta, Veerle Kremer, Nikolina Papac-Milicevic, A. Yaël Nossent, Eva van Ingen

Publikováno v: van Ingen, E, van den Homberg, D A L, van der Bent, M L, Mei, H, Papac-Milicevic, N, Kremer, V, Boon, R A, Quax, P H A, Wojta, J & Nossent, A Y 2022, ' C/D box snoRNA SNORD113-6/AF357425 plays a dual role in integrin signalling and arterial fibroblast function via pre-mRNA processing and 2'O-ribose methylation ', Human Molecular Genetics, vol. 31, no. 7, pp. 1051-1066 . https://doi.org/10.1093/hmg/ddab304
Human Molecular Genetics, 31(7), 1051-1066. OXFORD UNIV PRESS
Human Molecular Genetics, 31(7), 1051-1066. Oxford University Press

We have previously shown that C/D box small nucleolar RNAs (snoRNAs) transcribed from the DLK1-DIO3 locus on human chromosome 14 (14q32) are associated with cardiovascular disease. DLK1-DIO3 snoRNAs are ‘orphan snoRNAs’ that have no known targets

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2b58e08eb44713352dff1899c53be85
https://research.vumc.nl/en/publications/6e40b26c-732c-409a-ae7e-ad9a7fce5582

MEG8 regulates Tissue Factor Pathway Inhibitor 2 (TFPI2) expression in the endothelium

Autor: Reinier A Boon, Sarah Hilderink, Eva van Ingen, Veerle Kremer, Laura Stanicek, Diewertje I. Bink, Anne Yaël Nossent

A large portion of the genome is transcribed into non-coding RNA, which does not encode protein. Many long non-coding RNAs (lncRNAs) have been shown to be involved in important regulatory processes such as genomic imprinting and chromatin modificatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ccb9c82bc8f411ed683a170d132aa434
https://doi.org/10.21203/rs.3.rs-800527/v1

Decellularized extracellular matrix hydrogels as a delivery platform for MicroRNA and extracellular vesicle therapeutics

Autor: Joost P.G. Sluijter, Nathan W. Ng, Vera M. Pieters, Melissa J. Hernandez, Monika Dzieciatkowska, Kirk C. Hansen, Emma A. Mol, Roberto Gaetani, Eva van Ingen, Audrey E. Chang, Taylor R. Martin, Karen L. Christman

Publikováno v: Advanced Therapeutics

In the last decade, the use of microRNA (miRNA) and extracellular vesicle (EV) therapies has emerged as an alternative approach to mitigate the negative effects of several disease pathologies ranging from cancer to tissue and organ regeneration; howe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::925cd6f6710700e449a91e55671fb1d8
http://hdl.handle.net/11573/1280876