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Prolonged administration of low-dose cytarabine and thioguanine in elderly patients with acute myeloid leukaemia (AML) achieves high complete remission rates and prolonged survival

Autor: Anoop K Enjeti, Naomi Mackinlay, Eva Yip, Luke Coyle, William Stevenson, Vicki Katsioulas, Christopher Arthur, Jake Shortt, Keith Fay, Matthew Greenwood, Anastasios Nalpantidis, Anthony Jeffrey, Ian Kerridge

Publikováno v: Leukemialymphoma. 61(4)

The prognosis of AML in elderly patients is poor and research into novel therapeutic approaches is urgently needed. This study examined the use of low-dose chemotherapy with cytarabine and thioguanine administered in repetitive cycles in 62 elderly p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad22a70d9cf72994e773555bc227ec4d
https://pubmed.ncbi.nlm.nih.gov/31809629

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Treatment of Elderly and Unfit AML Patients with Prolonged Administration of Low Dose Cytarabine and Thioguanine Achieves High Complete Remission Rates in an Outpatient Setting

Autor: Vicki Katsioulas, William Stevenson, Anthony Jeffrey, Molly Forbes, Eva Yip, Christopher Arthur

Publikováno v: Blood. 132:3998-3998

Background: The treatment of elderly or unfit patients with AML is disappointing with little improvement in the past 30 years. Studies in the 1960s (Clarkson, Cancer 1972) explored the use of prolonged low dose cytarabine (Ara-C) with frequent bone m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::52ad7dd5feb09319ab04ee9798b74201
https://doi.org/10.1182/blood-2018-99-118027

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