Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Eva Tuomilehto-Wolf"'
Autor:
Janne Pitkäniemi, Sirkka-Liisa Varvio, Jukka Corander, Nella Lehti, Jukka Partanen, Eva Tuomilehto-Wolf, Jaakko Tuomilehto, Andrew Thomas, Elja Arjas
Publikováno v:
PLoS ONE, Vol 4, Iss 8, p e6836 (2009)
BACKGROUND:In genetic studies of rare complex diseases it is common to ascertain familial data from population based registries through all incident cases diagnosed during a pre-defined enrollment period. Such an ascertainment procedure is typically
Externí odkaz:
https://doaj.org/article/b20fd0b677374e6785f5fb6d6677c9b1
Autor:
Eva Tuomilehto-Wolf, Valma Harjutsalo, Tiina M. Järvinen, Maija E. Miettinen, Leena Kinnunen, J. Tuomilehto
Publikováno v:
Genes & Immunity. 9:207-213
Children with type 1 diabetes (T1D) susceptibility HLA genotypes are shown to have an increased birthweight. We investigated to what extent T1D-predisposing HLA haplotypes were associated with increased birthweight. A total of 1255 Finnish children c
Autor:
Säilä H, Anneli Savolainen, Eva Tuomilehto-Wolf, Jonathan A. Runstadler, Michael F. Seldin, Jaakko Tuomilehto, Kimmo Aho, Marjatta Leirisalo-Repo
Publikováno v:
Arthritis & Rheumatism. 52:247-256
Objective The SLC11A1 (formerly called NRAMP1) gene is important in natural resistance to a variety of intracellular infections mediated by macrophages and has been proposed as a candidate gene for autoimmune disease susceptibility. The aim of this s
Autor:
Cristian Guja, Kathleen M Gillespie, Barry Widmer, Lisa Godfrey, Constantin Ionescu-Tirgoviste, Sarah Nutland, Dag E. Undlien, Neil Walker, David A. Savage, Joanna M. M. Howson, David B. Dunger, Eva Tuomilehto-Wolf, John A. Todd, Kjersti S. Rønningen, Jaakko Tuomilehto, Sergey Nejentsev, Helen E. Rance, Jason D. Cooper, David P. Strachan, Susan M. Ring
Publikováno v:
Diabetes. 53:2709-2712
Vitamin D is known to modulate the immune system, and its administration has been associated with reduced risk of type 1 diabetes. Vitamin D acts via its receptor (VDR). Four single nucleotide polymorphisms (SNPs) of the VDR gene have been commonly s
Autor:
Jaakko Tuomilehto, Kimmo Aho, Eva Tuomilehto-Wolf, Säilä H, A. Savolainen, Michael F. Seldin, Jonathan A. Runstadler, Marjatta Leirisalo-Repo
Publikováno v:
Genes & Immunity. 5:562-571
This study further defines genetic susceptibility to JIA in the region centromeric to HLA-DRB1. DNA from 234 Finnish JIA nuclear families and 639 elderly Finnish control individuals was genotyped for five functional SNPs within the TAP2 and TAP1 loci
Autor:
Dag E. Undlien, Constantin Ionescu-Tı̂irgovişte, David A. Savage, Cristian Guja, Bryan J. Barratt, Eva Tuomilehto-Wolf, Jason D. Cooper, Alex C. Lam, Christopher E. Lowe, John S. Hulme, Joanna M. M. Howson, John A. Todd, Rebecca C.J. Twells, Jaakko Tuomilehto, Luc J. Smink
Publikováno v:
Diabetes. 53:2479-2482
Prior data associating the expression of lymphocyte-specific protein tyrosine kinase (LCK) with type 1 diabetes, its critical function in lymphocytes, and the linkage of the region to diabetes in the nonobese diabetic (NOD) mouse model make LCK a pre
Publikováno v:
Human Heredity. 57:69-79
Objectives: We explored the properties of the long-term survivor model (LTS) in the genetic association studies and studied allelic and haplotypic associations between the age at onset and partially latent susceptibility of type 1 diabetes (T1DM) and
Autor:
Kimmo Aho, Säilä H, Eva Tuomilehto-Wolf, Jaakko Tuomilehto, Jonathan A. Runstadler, Michael F. Seldin, A. Savolainen, Marjatta Leirisalo-Repo
Publikováno v:
Genes & Immunity. 4:326-335
This study used Finnish juvenile idiopathic arthritis (JIA) probands with pauciarticular and rheumatoid factor (RF) negative polyarticular subtypes of JIA to further define the genetic susceptibility to JIA. We examined 16 markers spanning an 18 cM r
Autor:
Neil Walker, Constantin Ionescu-Tirgoviste, Kathleen M Gillespie, Cristian Guja, David A. Savage, Jane Rogers, Eva Tuomilehto-Wolf, Christopher Patterson, Dag E. Undlien, Laurence B. Peterson, H Ueda, Michael L. Metzker, Francesco Cucca, Jaakko Tuomilehto, C Bordin, R Nithiyananthan, Hywel Snook, Amit Allahabadia, Simon G. Gregory, Helen E. Rance, Jayne A. Franklyn, John A. Todd, A C Lam, F Payne, John S. Hulme, Laura Esposito, Polly J. Bingley, Anne Smith, Giselle Chamberlain, Dennis Carson, Gough Scl., Kjersti S. Rønningen, Deborah J. Smyth, G Di Genova, Barry C. Healy, Alexander P. Maxwell, Joanne M. Heward, Sarah Nutland, Howson Jmm., Christopher E. Lowe, Twells Rcj., Hunter Kmd., Sarah Howlett, Heather J. Cordell, Ingrid Dahlman, J F Hess, David Clayton, Linda S. Wicker, Mathias H. Herr, Vincent H. Everett, Costantino Motzo, Dan Rainbow, Luc J. Smink
Publikováno v:
Ueda, H, Howson, J M M, Esposito, L, Heward, J, Snook, H, Chamberlain, G, Rainbow, D B, Hunter, K M D, Smith, A N, Di Genova, G, Herr, M H, Dahlman, I, Payne, F, Smyth, D, Lowe, C, Twells, R C J, Howlett, S, Healy, B, Nutland, S, Rance, H E, Everett, V, Smink, L J, Lam, A C, Cordell, H J, Walker, N M, Bordin, C, Hulme, J, Motzo, C, Cucca, F, Hess, J F, Metzker, M L, Rogers, J, Gregory, S, Allahabadia, A, Nithiyananthan, R, Tuomilehto-Wolf, E, Tuomilehto, J, Bingley, P, Gillespie, K M, Undlien, D E, Ronningen, K S, Guja, C, Ionescu-Tirgoviste, C, Savage, D, Maxwell, A, Carson, D, Patterson, C, Franklyn, J A, Clayton, D G, Peterson, L B, Wicker, L S, Todd, J A & Gough, S C L 2003, ' Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease ' Nature, vol. 423 (6939), no. 6939, pp. 506-511 .
Genes and mechanisms involved in common complex diseases, such as the autoimmune disorders that affect approximately 5% of the population, remain obscure. Here we identify polymorphisms of the cytotoxic T lymphocyte antigen 4 gene (CTLA4)--which enco
Autor:
Eva Tuomilehto-Wolf, Sarah Nutland, Gillian C.L. Johnson, Felicity Payne, Helen Stevens, Jaakko Tuomilehto, John A. Todd
Publikováno v:
Diabetes. 51:2866-2870
GAD2 maps to chromosome 10p11.23 and encodes the 65-kDa isoform of GAD65, a major autoantigen in type 1 diabetes. The genetic variation that influences expression of preproinsulin mRNA, encoding another major autoantigen in type 1 diabetes, has alrea