The ALS8 protein VAPB interacts with the ER–Golgi recycling protein YIF1A and regulates membrane delivery into dendrites

Autor: Dick Jaarsma, Casper C. Hoogenraad, Anna Akhmanova, Marijn Kuijpers, Ka Lou Yu, Eva Teuling

Publikováno v: EMBO Journal, 32(14), 2056-2072. Wiley-Blackwell

The vesicle-associated membrane protein (VAMP) associated protein B (VAPB) is an integral membrane protein localized to the endoplasmic reticulum (ER). The P56S mutation in VAPB has been linked to motor neuron degeneration in amyotrophic lateral scle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c14c57c21e6591db3a31b93593d1687f
https://doi.org/10.1038/emboj.2013.131

Identification of MOAG-4/SERF as a Regulator of Age-Related Proteotoxicity

Autor: Rogier Burggraaff, Petra van Bergeijk, Deguo Du, Jeroen van Rheenen, Annemieke T. van der Goot, Marit Wiersma, Tjakko J. van Ham, Robert M.W. Hofstra, Mats A. Holmberg, Ellen A. A. Nollen, G. Jerre van Veluw, Moisés García-Arencibia, Karen L. Thijssen, David C. Rubinsztein, Eva Teuling, Hyun Eui Kim

Publikováno v: Cell, 142(4), 601-612. CELL PRESS

SummaryFibrillar protein aggregates are the major pathological hallmark of several incurable, age-related, neurodegenerative disorders. These aggregates typically contain aggregation-prone pathogenic proteins, such as amyloid-beta in Alzheimer's dise

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bb1426400fb280f694bb6f8f8bb7759

ATF3 expression precedes death of spinal motoneurons in amyotrophic lateral sclerosis-SOD1 transgenic mice and correlates with c-Jun phosphorylation, CHOP expression, somato-dendritic ubiquitination and Golgi fragmentation

Autor: Eva Teuling, Pim J. French, Elize D. Haasdijk, Angela S Vlug, Casper C. Hoogenraad, Dick Jaarsma

Publikováno v: European Journal of Neuroscience, 22(8), 1881-1894. Wiley-Blackwell Publishing Ltd

To obtain insight into the morphological and molecular correlates of motoneuron degeneration in amyotrophic lateral sclerosis (ALS) mice that express G93A mutant superoxide dismutase (SOD)1 (G93A mice), we have mapped and characterized 'sick' motoneu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68012890bc5a02164900bfa9e6df1f55
https://doi.org/10.1111/j.1460-9568.2005.04389.x

Modifiers of mutant huntingtin aggregation: functional conservation of C. elegans-modifiers of polyglutamine aggregation

Autor: Eva Teuling, Sven Veenje, Annika Bourgonje, Ellen A. A. Nollen, Joeri van der Velde, Morris A. Swertz, Karen L. Thijssen, Jelle de Boer

Publikováno v: PLoS Currents
PLoS Currents, 3(RRN1255)

Protein aggregation is a common hallmark of a number of age-related neurodegenerative diseases, including Alzheimer's, Parkinson's, and polyglutamine-expansion disorders such as Huntington's disease, but how aggregation-prone proteins lead to patholo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35ac7b7dac8fdec90664aa446df5e0f6
https://pubmed.ncbi.nlm.nih.gov/21915392

Intrinsic Plasticity Complements Long-Term Potentiation in Parallel Fiber Input Gain Control in Cerebellar Purkinje Cells

Autor: Amor Belmeguenai, Gen Ohtsuki, Eva Teuling, Claire Piochon, Eric Hosy, Christine M. Pedroarena, Marcel T. G. de Jeu, Chris I. De Zeeuw, Qionger He, Ype Elgersma, Christian Hansel, Fredrik Bengtsson, Henrik Jörntell

Publikováno v: The Journal of Neuroscience, 30(41), 13630-13643. Oxford University Press
Journal of Neuroscience, 30(41), 13630-13643. Society for Neuroscience
Journal of Neuroscience; 30(41), pp 13630-13643 (2010)
Journal of Neuroscience, 30, 13630-13643. Society for Neuroscience

Synaptic gain control and information storage in neural networks are mediated by alterations in synaptic transmission, such as in long-term potentiation (LTP). Here, we show using bothin vitroandin vivorecordings from the rat cerebellum that tetaniza

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d21fa3e6d26799fb44aed9f9141a5ce
http://lup.lub.lu.se/record/1720762