A Combination of Intrathecal and Intramuscular Application of Human Mesenchymal Stem Cells Partly Reduces the Activation of Necroptosis in the Spinal Cord of SOD1G93A Rats

Autor: Monika Řehořová, Ingrid Vargová, Serhiy Forostyak, Irena Vacková, Karolína Turnovcová, Helena Kupcová Skalníková, Petr Vodička, Šárka Kubinová, Eva Syková, Pavla Jendelová

Publikováno v: Stem Cells Translational Medicine, Vol 8, Iss 6, Pp 535-547 (2019)

Abstract An increasing number of studies have demonstrated the beneficial effects of human mesenchymal stem cells (hMSC) in the treatment of amyotrophic lateral sclerosis (ALS). We compared the effect of repeated intrathecal applications of hMSC or t

Externí odkaz: https://doaj.org/article/b0b715de594a4c4fa7d5f478f35d4e55

Transplantation of Mesenchymal Stromal Cells in Patients with Amyotrophic Lateral Sclerosis: Results of Phase I/IIa Clinical Trial

Autor: Eva Syková M.D., Ph.D., Dr.Sc., Petr Rychmach, Ivana Drahorádová, ŠImona Konrádová, Kateřina Růžičková, Ivan Voříšek, Serhiy Forostyak, Aleš Homola, Martin Bojar

Publikováno v: Cell Transplantation, Vol 26 (2017)

Amyotrophic lateral sclerosis (ALS) is a progressive untreatable neurodegenerative disorder, leading to the death of the cortical and spinal motoneurons (MNs). Bone marrow-derived mesenchymal stem/stromal cells (BM-MSCs) may represent a new approach

Externí odkaz: https://doaj.org/article/7cbcaa11ce034fb7a0f42b5ff4c67590

Life on magnets: stem cell networking on micro-magnet arrays.

Autor: Vitalii Zablotskii, Alexandr Dejneka, Šárka Kubinová, Damien Le-Roy, Frédéric Dumas-Bouchiat, Dominique Givord, Nora M Dempsey, Eva Syková

Publikováno v: PLoS ONE, Vol 8, Iss 8, p e70416 (2013)

Interactions between a micro-magnet array and living cells may guide the establishment of cell networks due to the cellular response to a magnetic field. To manipulate mesenchymal stem cells free of magnetic nanoparticles by a high magnetic field gra

Externí odkaz: https://doaj.org/article/c84207f1bcde40f9a24b40cff74f0039

A Combination of Intrathecal and Intramuscular Application of Human Mesenchymal Stem Cells Partly Reduces the Activation of Necroptosis in the Spinal Cord of SOD1G93A Rats

Autor: Ingrid Vargová, Eva Syková, Serhiy Forostyak, Karolina Turnovcova, Petr Vodicka, Helena Kupcova Skalnikova, Pavla Jendelova, Šárka Kubinová, Monika Řehořová, Irena Vackova

Publikováno v: Stem Cells Translational Medicine, Vol 8, Iss 6, Pp 535-547 (2019)

An increasing number of studies have demonstrated the beneficial effects of human mesenchymal stem cells (hMSC) in the treatment of amyotrophic lateral sclerosis (ALS). We compared the effect of repeated intrathecal applications of hMSC or their cond

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d65c55dde4f320d47771e46149462b7
https://doi.org/10.1002/sctm.18-0223

Transplantation of Neural Precursors Derived from Induced Pluripotent Cells Preserve Perineuronal Nets and Stimulate Neural Plasticity in ALS Rats

Autor: Jan Kriska, Eva Syková, Nataliya Romanyuk, Oksana Forostyak, Miroslava Anderova, Pavla Jendelova, Serhiy Forostyak, Govindan Dayanithi, James W. Fawcett, Jessica C. F. Kwok, Monika Rehorova, Ruma Raha-Chowdhury

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, MDPI, 2020, 21 (24), pp.9593. ⟨10.3390/ijms21249593⟩
International Journal of Molecular Sciences, Vol 21, Iss 9593, p 9593 (2020)
Volume 21
Issue 24

A promising therapeutic strategy for amyotrophic lateral sclerosis (ALS) treatment is stem cell therapy. Neural progenitors derived from induced pluripotent cells (NP-iPS) might rescue or replace dying motoneurons (MNs). However, the mechanisms respo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95c3fccff0d4a28fc73475181963ce63
https://www.repository.cam.ac.uk/handle/1810/322512