Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Eva Spitzer"'
Autor:
J. Krocker, Mohammad Reza Abbaszadegan, Frank Schmidt, Eva Spitzer, Richard Grosse, Kathrin Pötschick, Dirk Elling, Andrea Hauser, Ute Buwitt, Frank-Roman Lauter
Publikováno v:
International Journal of Cancer. 85:474-481
We have developed a 2-stage protocol for BRCA1 and BRCA2 mutation screening from blood spot paper. Stage 1 screening was aimed to analyze patients at highest risk for the most common disease-associated sequence variants listed in the BIC database. Ac
Autor:
Eva Spitzer, Walter Birchmeier, Martin Sachs, Helga Naundorf, Catherin Niemann, Guido Hartmann, Volker Brinkmann
Publikováno v:
The Journal of Cell Biology
We have established a cell culture system that reproduces morphogenic processes in the developing mammary gland. EpH4 mouse mammary epithelial cells cultured in matrigel form branched tubules in the presence of hepatocyte growth factor/scatter factor
Publikováno v:
Journal of Cellular Physiology. 164:1-8
Antiprogestins possess a potent antitumor activity in hormone-dependent experimental breast cancer models. Though the underlying mechanism is not clear, induction of functional differentiation seems to be a major event. This study attempts to test di
Publikováno v:
Journal of Cellular Biochemistry. 57:495-508
Epidermal growth factor (EGF) has been suggested to be involved in mammary gland development by mitogenic stimulation of the ductal and alveolar epithelium in virgin mice. The present studies demonstrate that also in late-pregnant mice EGF leads to p
Autor:
Richard Grosse, I. Schönborn, C. Minguillon, Eva Spitzer, W. Zschiesche, K. Ebeling, M. Möhner
Publikováno v:
Journal of Cancer Research and Clinical Oncology. 121:115-122
Expression of proliferating cell nuclear antigen (PCNA) and c-erbB-2 oncoprotein has been assessed in 471 women with breast cancer to evaluate their prognostic value as compared to conventional histopathological factors. In univariate analysis, high
Publikováno v:
Histochemistry and Cell Biology. 103:147-156
Cellular fatty acid-binding proteins (FABP) are a highly conserved family of proteins consisting of several subtypes, among them the mammary-derived growth inhibitor (MDGI) which is quite homologous to or even identical with the heart-type FABP (H-FA
Autor:
Barbara Thamm-Mücke, Sabine Purmann, Alessandra Baumer, Heyko Skladny, Cornelia Kraus, Peter M. Kroisel, Gabriele Sander, Lothar Kochhan, Roland Achmann, Bernd Dworniczak, Stephanie Kleinle, Bernhard Horsthemke, Dieter Gläser, Joachim Burger, Christa Aulehla-Scholz, Ernst Krasemann, Bart Janssen, Eva Spitzer, Elke Holinski-Feder, Helga Weirich, Hansjörg Plendl, Karin Buiting, Christina Lich, Raymonda Varon-Mateeva, Andreas Weinhäusel
Publikováno v:
European Journal of Human Genetics. 11:913-915
Autor:
A Kromminga, Wolfgang Zschiesche, A Lezius, Yanmin Yang, Eva Spitzer, Nicholas Kenney, J.H. Veerkamp, M Li, F Spener, Thomas Müller
Publikováno v:
The Journal of Cell Biology
Mammary gland development is controlled by systemic hormones and by growth factors that might complement or mediate hormonal action. Peptides that locally signal growth cessation and stimulate differentiation of the developing epithelium have not bee
Autor:
Richard Grosse, Eva Spitzer, C. Minguillon, K. Ebeling, M. Möhner, I. Schönborn, Wolfgang Zschiesche
Publikováno v:
Breast Cancer Research and Treatment. 29:287-295
The prognostic value of c-erbB-2 protein overexpression has been evaluated in 463 patients with operable breast cancer after a median follow-up of 66 months. Overexpression was observed in 99/463 (21%) of the breast tumors. It showed significant posi
Autor:
K. Eckert, R. Perez, Wolfgang Zschiesche, Antonio Fernández, F.-D. Boehmer, Eva Spitzer, Richard Grosse
Publikováno v:
Journal of Cellular Biochemistry. 49:157-165
The prognostic significance of the epidermal growth factor receptor status (EGF-R-status) for certain human tumors requires the development of antibodies useful for clinical application. We used purified receptor preparations to generate monoclonal a