Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Eva Smorodina"'
Autor:
Habib Bashour, Eva Smorodina, Matteo Pariset, Jahn Zhong, Rahmad Akbar, Maria Chernigovskaya, Khang Lê Quý, Igor Snapkow, Puneet Rawat, Konrad Krawczyk, Geir Kjetil Sandve, Jose Gutierrez-Marcos, Daniel Nakhaee-Zadeh Gutierrez, Jan Terje Andersen, Victor Greiff
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-25 (2024)
Abstract Designing effective monoclonal antibody (mAb) therapeutics faces a multi-parameter optimization challenge known as “developability”, which reflects an antibody’s ability to progress through development stages based on its physicochemic
Externí odkaz:
https://doaj.org/article/54691d3c1e42401d80a1f1a4a75878b7
Autor:
Lorenzo Federico, Brandon Malone, Simen Tennøe, Viktoriia Chaban, Julie Røkke Osen, Murat Gainullin, Eva Smorodina, Hassen Kared, Rahmad Akbar, Victor Greiff, Richard Stratford, Trevor Clancy, Ludvig Andre Munthe
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/71696a78c10c4e30a836d19c193d086e
Publikováno v:
PLoS ONE, Vol 19, Iss 4, p e0289644 (2024)
Glutamate transporters play key roles in nervous physiology by modulating excitatory neurotransmitter levels, when malfunctioning, involving in a wide range of neurological and physiological disorders. However, integral transmembrane proteins includi
Externí odkaz:
https://doaj.org/article/23e6c85010574c9a85f92ddbae025454
Publikováno v:
QRB Discovery, Vol 5 (2024)
Human ATP-binding cassette (ABC) transporters are one of the largest families of membrane proteins and perform diverse functions. Many of them are associated with multidrug resistance that often results in cancer treatment with poor outcomes. Here, w
Externí odkaz:
https://doaj.org/article/52e885aef2ec4996bad45e082b5bfb27
Autor:
Lorenzo Federico, Brandon Malone, Simen Tennøe, Viktoriia Chaban, Julie Røkke Osen, Murat Gainullin, Eva Smorodina, Hassen Kared, Rahmad Akbar, Victor Greiff, Richard Stratford, Trevor Clancy, Ludvig Andre Munthe
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
During the COVID-19 pandemic we utilized an AI-driven T cell epitope prediction tool, the NEC Immune Profiler (NIP) to scrutinize and predict regions of T cell immunogenicity (hotspots) from the entire SARS-CoV-2 viral proteome. These immunogenic reg
Externí odkaz:
https://doaj.org/article/196a2fd0f4914004b3f5f63d54028800
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Solute carrier transporters are integral membrane proteins, and are important for diverse cellular nutrient transports, metabolism, energy demand, and other vital biological activities. They have recently been implicated in pancreatic cancer
Externí odkaz:
https://doaj.org/article/8487b93acc484b7f99b946b78e4d5893
Publikováno v:
PLoS ONE, Vol 18, Iss 8, p e0290360 (2023)
Beta-barrel outer membrane proteins (OMP) are integral components of Gram-negative bacteria, eukaryotic mitochondria, and chloroplasts. They play essential roles in various cellular processes including nutrient transport, membrane stability, host-pat
Externí odkaz:
https://doaj.org/article/faccd523f6df4f8ea609ed59684c2208
Autor:
Rahmad Akbar, Habib Bashour, Puneet Rawat, Philippe A. Robert, Eva Smorodina, Tudor-Stefan Cotet, Karine Flem-Karlsen, Robert Frank, Brij Bhushan Mehta, Mai Ha Vu, Talip Zengin, Jose Gutierrez-Marcos, Fridtjof Lund-Johansen, Jan Terje Andersen, Victor Greiff
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
Although the therapeutic efficacy and commercial success of monoclonal antibodies (mAbs) are tremendous, the design and discovery of new candidates remain a time and cost-intensive endeavor. In this regard, progress in the generation of data describi
Externí odkaz:
https://doaj.org/article/aa3c08b3fb154e0dafa6136e2d38c0d4
Publikováno v:
QRB Discovery, Vol 3 (2022)
Membrane transporters including glucose transporters (GLUTs) are involved in cellular energy supplies, cell metabolism and other vital biological activities. They have also been implicated in cancer proliferation and metastasis, thus they represent a
Externí odkaz:
https://doaj.org/article/0340b1b9ee4b49868b1eec78c5ca9470
Autor:
Esmaeil Dorraji, Elin Borgen, Dario Segura-Peña, Puneet Rawat, Eva Smorodina, Claire Dunn, Victor Greiff, Nikolina Sekulić, Hege Russnes, Jon Amund Kyte
Publikováno v:
Cancers, Vol 14, Iss 19, p 4859 (2022)
The expression of human epidermal growth factor receptor 2 (HER2) is a key classification factor in breast cancer. Many breast cancers express isoforms of HER2 with truncated carboxy-terminal fragments (CTF), collectively known as p95HER2. A common p
Externí odkaz:
https://doaj.org/article/fdcf156c92a84e1eaadd3170a7c54e87