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pro vyhledávání: '"Eva Smolenova"'
Publikováno v:
Journal of Leukocyte Biology. 81:1149-1158
To clarify the sorting mechanism of the lysosomal/granular proteoglycan serglycin, we treated human promonocytic U937 cells with p-nitrophenyl-β-D-xyloside (PNP-xyl) and cycloheximide. In the absence of protein synthesis, the carbohydrate moiety of
Autor:
Eva Smolenova, Norbert Werth, Konrad Sandhoff, Andrej Hasilik, Hans-Wilhelm Grosch, Madanan Madathiparambil Gopalakrishnan, Silvia Locatelli-Hoops, Michael Nettersheim
Publikováno v:
Biochemical Journal. 383:507-515
Before delivery to endosomes, portions of proCD (procathepsin D) and proSAP (prosaposin) are assembled into complexes. We demonstrate that such complexes are also present in secretions of cultured cells. To study the formation and properties of the c
Publikováno v:
Cellular immunology. 246(1)
Mutations in the neutrophil elastase (NE) gene have been postulated to interfere with normal intracellular trafficking of NE as an AP3-interacting membrane integrated protein and to cause severe congenital or cyclic neutropenia in humans. Here, we sh