Výsledky vyhledávání - "Eva Sherbetjian"

Identification of M4205─A Highly Selective Inhibitor of KIT Mutations for Treatment of Unresectable Metastatic or Recurrent Gastrointestinal Stromal Tumors

Autor: Andreas Blum, Dieter Dorsch, Nina Linde, Susanne Brandstetter, Hans-Peter Buchstaller, Michael Busch, Nina Glaser, Ulrich Grädler, Aaron Ruff, Carl Petersson, Hanno Schieferstein, Eva Sherbetjian, Christina Esdar

Publikováno v: Journal of Medicinal Chemistry. 66:2386-2395

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::71e540463f0bb41b227c72819981e3a5
https://doi.org/10.1021/acs.jmedchem.2c00851

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Utility of preclinical species for uncertainty assessment and correction of prediction of human volume of distribution using the Rodgers-Lukacova model

Autor: Eva, Sherbetjian, Sheila-Annie, Peters, Carl, Petersson

Publikováno v: Xenobiotica. 52:661-668

Prediction of rat, dog, monkey, and human volume of distribution (VD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ee31a9651134f4feee97caccdcc8e11
https://doi.org/10.1080/00498254.2022.2132427

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Abstract 1482: M4645 is a potent and highly selective inhibitor of disease relevant cKIT mutations for the treatment of metastatic or recurrent GIST

Autor: Dieter Dorsch, Nina Glaser, Eva Sherbetjian, Ulrich Graedler, Andreas Blum, Michael Busch, Nina Linde, Carl Petersson, Christina Esdar, Aaron Ruff

Publikováno v: Cancer Research. 81:1482-1482

Oncogenic mutations in cKIT in exons 9 and 11 are the main driver of gastrointestinal stromal tumors (GIST). Imatinib is standard of care in 1L in unresectable metastatic or recurrent GIST, yet secondary resistance mutations in exons 13/14 and 17/18

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f127f8d8c63cdc63bbc6c35d9082c956
https://doi.org/10.1158/1538-7445.am2021-1482

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Characterization of Pharmacokinetics in the Göttingen Minipig with Reference Human Drugs: An In Vitro and In Vivo Approach

Autor: Russell Jones, Floriane Lignet, Eva Sherbetjian, Claudia Suenderhauf, Nicole A. Kratochwil, Michael B. Otteneder, Thomas Singer, Neil Parrott

Publikováno v: Pharmaceutical Research. 33:2565-2579

This study aims to expand our understanding of the mechanisms of drug absorption, distribution, metabolism and excretion in the Gottingen minipig to aid a knowledge-driven selection of the optimal species for preclinical pharmaceutical research. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fbb38b8c70b301d360da3e66611e9a4
https://doi.org/10.1007/s11095-016-1982-5

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Erratum to: Characterization of Pharmacokinetics in the Göttingen Minipig with Reference Human Drugs: An In Vitro and In Vivo Approach

Autor: Floriane Lignet, Eva Sherbetjian, Nicole Kratochwil, Russell Jones, Claudia Suenderhauf, Michael B. Otteneder, Thomas Singer, Neil Parrott

Publikováno v: Pharmaceutical Research. 33:2844-2844

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::687c870d69d30a5f9aa630de7cef65e3
https://doi.org/10.1007/s11095-016-2026-x

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