Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Eva Sahakian"'
Optimization of In Vitro Th17 Polarization for Adoptive Cell Therapy in Chronic Lymphocytic Leukemia
Autor:
Wael Gamal, Melanie Mediavilla-Varela, Angimar Uriepero-Palma, Javier Pinilla-Ibarz, Eva Sahakian
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 12, p 6324 (2024)
Although preclinical investigations have shown notable efficacy in solid tumor models utilizing in vitro-differentiated Th17 cells for adoptive cell therapy (ACT), the potential benefits of this strategy in enhancing ACT efficacy in hematological mal
Externí odkaz:
https://doaj.org/article/b4dfe0ff5d9f4008bdf10b43d459e4ed
Publikováno v:
Proceedings, Vol 100, Iss 1, p 19 (2024)
Transcription factors bind specific DNA motifs to regulate the expression of target genes in order to maintain normal hematopoiesis [...]
Externí odkaz:
https://doaj.org/article/e2dad4ac88dc4d56a01b5248197082b1
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Regulatory T cells (Tregs) are responsible for maintaining immune homeostasis by controlling immune responses. They can be characterized by concomitant expression of FoxP3, CD25 and inhibitory receptors such as PD-1 and CTLA-4. Tregs are key players
Externí odkaz:
https://doaj.org/article/155e7eb565734d69919d21c61f736ad6
Autor:
AGM Mostofa, Allison Distler, Mark B. Meads, Eva Sahakian, John J. Powers, Alexandra Achille, David Noyes, Gabriela Wright, Bin Fang, Victoria Izumi, John Koomen, Rupal Rampakrishnan, Tuan P. Nguyen, Gabriel De Avila, Ariosto S. Silva, Praneeth Sudalagunta, Rafael Renatino Canevarolo, Maria D. Coelho Siqueira Silva, Raghunandan Reddy Alugubelli, Hongyue A. Dai, Amit Kulkarni, William S. Dalton, Oliver A. Hampton, Eric A. Welsh, Jamie K. Teer, Alexandre Tungesvik, Kenneth L. Wright, Javier Pinilla-Ibarz, Eduardo M. Sotomayor, Kenneth H. Shain, Jason Brayer
Publikováno v:
JCI Insight, Vol 6, Iss 24 (2021)
The clinical utility of histone/protein deacetylase (HDAC) inhibitors in combinatorial regimens with proteasome inhibitors for patients with relapsed and refractory multiple myeloma (MM) is often limited by excessive toxicity due to HDAC inhibitor pr
Externí odkaz:
https://doaj.org/article/7fe4645c54d74f3db9e69957840e8738
Autor:
Cameron K. Tebbi, Aruna Badiga, Eva Sahakian, John J. Powers, Alex N. Achille, Saumil Patel, Felicia Migone
Publikováno v:
Cancer Treatment and Research Communications, Vol 26, Iss , Pp 100279- (2021)
The etiology of acute lymphoblastic leukemia (ALL) remains unknown. A recent “two-hit” model for the occurrence of precursor B cell acute lymphoblastic leukemia propose that this disease arises through a two-step process, including predisposing g
Externí odkaz:
https://doaj.org/article/adf5aca5c1084e31971177c5e17d8e94
Autor:
Kamira Maharaj, John J. Powers, Melanie Mediavilla-Varela, Alex Achille, Wael Gamal, Steven Quayle, Simon S. Jones, Eva Sahakian, Javier Pinilla-Ibarz
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Development of chronic lymphocytic leukemia (CLL) is associated with severe immune dysfunction. T-cell exhaustion, immune checkpoint upregulation, and increase of regulatory T cells contribute to an immunosuppressive tumor microenvironment. As a resu
Externí odkaz:
https://doaj.org/article/6d90ade24c674ca0b70cd526e4ee4350
Publikováno v:
Blood Advances, Vol 1, Iss 21, Pp 1867-1875 (2017)
Abstract: Approved therapies that target the B-cell receptor (BCR) signaling pathway, such as ibrutinib and idelalisib, are known to show activity in chronic lymphocytic leukemia (CLL) via their direct effects on crucial survival pathways in malignan
Externí odkaz:
https://doaj.org/article/644163ab67484ac48b47c8c21e046186
Autor:
Eduardo M. Sotomayor, Jianguo Tao, Mitchell Smith, Said Sebti, Javier Pinilla-Ibarz, Alejandro Villagra, Karrune V. Woan, Eva Sahakian, Bijal Shah, Zi Wang, Pedro Horna, Hongwei Wang, Fengdong Cheng
PDF file - 426K, Percent of T-cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::313ee2e6c82fbaa7d14782f06a602338
https://doi.org/10.1158/0008-5472.22391792
https://doi.org/10.1158/0008-5472.22391792
Autor:
Eduardo M. Sotomayor, Jianguo Tao, Mitchell Smith, Said Sebti, Javier Pinilla-Ibarz, Alejandro Villagra, Karrune V. Woan, Eva Sahakian, Bijal Shah, Zi Wang, Pedro Horna, Hongwei Wang, Fengdong Cheng
PDF file - 111K, Viability and proliferation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fa12569eed995df234911392ccc001a
https://doi.org/10.1158/0008-5472.22391795
https://doi.org/10.1158/0008-5472.22391795
Autor:
Eduardo M. Sotomayor, Jianguo Tao, Mitchell Smith, Said Sebti, Javier Pinilla-Ibarz, Alejandro Villagra, Karrune V. Woan, Eva Sahakian, Bijal Shah, Zi Wang, Pedro Horna, Hongwei Wang, Fengdong Cheng
PDF file - 65K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1555724b7c8998aa72ba6c50b7df956c
https://doi.org/10.1158/0008-5472.22391789
https://doi.org/10.1158/0008-5472.22391789