Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Eva S. Schaffert"'
Publikováno v:
Tsakos, M, Schaffert, E S, Clement, L L, Villadsen, N L & Poulsen, T 2015, ' Ester Coupling Reactions – an Enduring Challenge in the Chemical Synthesis of Bioactive Natural Products ', Natural Product Reports, vol. 32, no. 4, pp. 605-632 . https://doi.org/10.1039/c4np00106k
Covering: up to 2014 In this review we investigate the use of complex ester fragment couplings within natural product total synthesis campaigns. We first outline the different biosynthetic and chemical strategies for performing complex ester coupling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79a7ea2315ed487b80e289b09b6e1ba4
https://doi.org/10.1039/c4np00106k
https://doi.org/10.1039/c4np00106k
Publikováno v:
ChemInform. 47
Covering: up to 2014 In this review we investigate the use of complex ester fragment couplings within natural product total synthesis campaigns. We first outline the different biosynthetic and chemical strategies for performing complex ester coupling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7d80a6dd90a73bc0f00504e373fdd58
https://doi.org/10.1002/chin.201617235
https://doi.org/10.1002/chin.201617235
Autor:
Nikolaj L. Villadsen, Eva S. Schaffert, Sebastiano Rupiani, Michail Tsakos, Kristian M. Jacobsen, Frank N. Olsen, Lise L. Clement, Rasmus Djurhuus, Thomas B. Poulsen, Wanwan Yu
Publikováno v:
ChemInform. 47
We report a concise asymmetric synthesis of rakicidin A, a macrocyclic depsipeptide that selectively inhibits the growth of hypoxic cancer cells and stem-like leukemia cells. Key transformations include a diastereoselective organocatalytic cross-aldo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c261d3badd5416d8267f8b885f66dfcf
https://doi.org/10.1002/chin.201611219
https://doi.org/10.1002/chin.201611219
Autor:
Eva S. Schaffert, Thomas B. Poulsen, Lise L. Clement, Michail Tsakos, Kristian M. Jacobsen, Frank N. Olsen, Nikolaj L. Villadsen, Wanwan Yu, Rasmus Djurhuus, Sebastiano Rupiani
Publikováno v:
Tsakos, M, Clement, L L, Schaffert, E S, Olsen, F N, Rupiani, S, Djurhuus, R, Yu, W, Jacobsen, K M, Villadsen, N L & Poulsen, T B 2016, ' Total synthesis and biological evaluation of rakicidin A and discovery of a simplified bioactive analogue ', Angewandte Chemie International Edition, vol. 55, no. 3, pp. 1030-1035 . https://doi.org/10.1002/anie.201509926
We report a concise asymmetric synthesis of rakicidin A, a macrocyclic depsipeptide that selectively inhibits the growth of hypoxic cancer cells and stem-like leukemia cells. Key transformations include a diastereoselective organocatalytic cross-aldo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0245b89a702025d929aa044ca5b68fb8
https://pure.au.dk/portal/da/publications/total-synthesis-and-biological-evaluation-of-rakicidin-a-and-discovery-of-a-simplified-bioactive-analogue(05a64625-14e7-42ce-8b88-587763a1630e).html
https://pure.au.dk/portal/da/publications/total-synthesis-and-biological-evaluation-of-rakicidin-a-and-discovery-of-a-simplified-bioactive-analogue(05a64625-14e7-42ce-8b88-587763a1630e).html
Autor:
Michail Tsakos, Jan J. Enghild, Carsten Scavenius, Eva S. Schaffert, Thomas B. Poulsen, Lise L. Clement
Publikováno v:
Clement, L L, Tsakos, M, Schaffert, E S, Scavenius, C, Enghild, J J & Poulsen, T B 2015, ' The amido-pentadienoate-functionality of the rakicidins is a thiol reactive electrophile : development of a general synthetic strategy ', Chemical Communications, vol. 51, no. 62, pp. 12427-12430 . https://doi.org/10.1039/c5cc04500b
We demonstrate that a unique class-defining functionality (mc-APD) found in macrocyclic natural products with potent anti-cancer activity, imparts these compounds with electrophilic reactivity. The mc-APD group represents an interesting structural hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e9c06d234083a340eccf36ddcb83987
https://pure.au.dk/portal/da/publications/the-amidopentadienoatefunctionality-of-the-rakicidins-is-a-thiol-reactive-electrophile(65f623f3-cc4b-4453-a4ca-daa16e780836).html
https://pure.au.dk/portal/da/publications/the-amidopentadienoatefunctionality-of-the-rakicidins-is-a-thiol-reactive-electrophile(65f623f3-cc4b-4453-a4ca-daa16e780836).html
Autor:
Kristian M. Jacobsen, Thomas B. Poulsen, Neela D. S. Rambaruth, Kurt Drickamer, Lise L. Clement, Mogens Johannsen, Eva S. Schaffert, Ulrik B. Keiding
Publikováno v:
Medchemcomm
Jacobsen, K M, Keiding, U, Clement, L L, Schaffert, E S, Rambaruth, N, Johannsen, M, Drickamer, K & Poulsen, T 2015, ' The Natural Product Brartemicin is a High Affinity Ligand for the Carbohydrate-Recognition Domain of the Macrophage Receptor Mincle ', MedChemComm, vol. 6, no. 4, pp. 647-652 . https://doi.org/10.1039/c4md00512k, https://doi.org/10.1039/C4MD00512K
Jacobsen, K M, Keiding, U, Clement, L L, Schaffert, E S, Rambaruth, N, Johannsen, M, Drickamer, K & Poulsen, T 2015, ' The Natural Product Brartemicin is a High Affinity Ligand for the Carbohydrate-Recognition Domain of the Macrophage Receptor Mincle ', MedChemComm, vol. 6, no. 4, pp. 647-652 . https://doi.org/10.1039/c4md00512k, https://doi.org/10.1039/C4MD00512K
We demonstrate that the natural product brartemicin, a newly discovered inhibitor of cancer cell invasion, is a high-affinity ligand of the carbohydrate-recognition domain (CRD) of the C-type lectin mincle.
We demonstrate that the natural produc
We demonstrate that the natural produc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efcc9c956c2759bfc8179a6068e160b1
http://hdl.handle.net/10044/1/19625
http://hdl.handle.net/10044/1/19625
Publikováno v:
Bioorganicmedicinal chemistry. 19(21)
1,5-Disubstituted and 5-monosubstituted aminomethyltetrazole derivatives derived from glycine were synthesized employing a TMSN(3)-modified variant of the Ugi reaction as a key step. All compounds were evaluated regarding their inhibitory potency and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7032872f7f5750ea9f3b464e4c1110c3
https://pubmed.ncbi.nlm.nih.gov/21940173
https://pubmed.ncbi.nlm.nih.gov/21940173