Myelodysplastic Cells in Patients Reprogram Mesenchymal Stromal Cells to Establish a Transplantable Stem Cell Niche Disease Unit

Autor: Julia Obländer, Bettina Zens, Verena Nowak, Alexander Kohlmann, Simon Raffel, Florian Nolte, Hind Medyouf, Marita Staller, Eva Riedl, Nadine Muller, Maximilian Mossner, Thilo John, Daniel Nowak, Stephanie Fey, Katja Müdder, Jovita Vogler, Carl Herrmann, Johann Christoph Jann, Georgia Metzgeroth, Alice Fabarius, Corinna Klein, Wolf-Karsten Hofmann, Henning Roehl, Amelie Lier, Christian Eisen, Andreas Trumpp, Claudia Haferlach, Uwe Platzbecker

Publikováno v: Cell Stem Cell. 14(6):824-837

SummaryMyelodysplastic syndromes (MDSs) are a heterogeneous group of myeloid neoplasms with defects in hematopoietic stem and progenitor cells (HSPCs) and possibly the HSPC niche. Here, we show that patient-derived mesenchymal stromal cells (MDS MSCs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d885881af657b6f506a2d45799c35af2

Anserine inhibits carnosine degradation but in human serum carnosinase (CN1) is not correlated with histidine dipeptide concentration

Autor: Georg F. Hoffmann, Daniel Gotthardt, Erwin E.W. Jansen, Cornelis Jakobs, Johannes Wedel, Benito A. Yard, Bart Janssen, Verena Peters, Christine Fischer, Johannes Zschocke, Hannes Koppel, Eva Riedl

Publikováno v: Clinica Chimica Acta, 412(3-4), 263-267. Elsevier
Peters, V, Jansen, E E W, Jakobs, C A J M, Riedl, E, Janssen, B, Yard, B A, Wedel, J, Hoffmann, G F, Zschocke, J, Gotthardt, D, Fischer, C & Koppel, H 2011, ' Anserine inhibits carnosine degradation but in human serum carnosinase (CN1) is not correlated with histidine dipeptide concentration ', Clinica Chimica Acta, vol. 412, no. 3-4, pp. 263-267 . https://doi.org/10.1016/j.cca.2010.10.016

We reported an association of a particular allele of the carnosinase (CNDP1 Mannheim) gene with reduced serum carnosinase (CN1) activity and absence of nephropathy in diabetic patients. Carnosine protects against the adverse effects of high glucose l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e27f0fd66502a2777ad76f77e2237363
https://doi.org/10.1016/j.cca.2010.10.016

N-Glycosylation of Carnosinase Influences Protein Secretion and Enzyme Activity

Autor: Verena Peters, Eva Riedl, Jacob van den Born, Benito A. Yard, Fokko J. van der Woude, Sibylle Sauerhoefer, Gerjan Navis, Paula Sternik, Paul Brinkkoetter, Bart Janssen, Robert H. Henning, Hannes Koeppel, Stephan J. L. Bakker, Frederick Pfister, Hanswalter Zentgraf

Publikováno v: Diabetes

OBJECTIVE The (CTG)n polymorphism in the serum carnosinase (CN-1) gene affects CN-1 secretion. Since CN-1 is heavily glycosylated and glycosylation might influence protein secretion as well, we tested the role of N-glycosylation for CN-1 secretion an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6971aa42ddcada70b01bb19a60a4b615
http://europepmc.org/articles/PMC2911063

Different conformational forms of serum carnosinase detected by a newly developed sandwich ELISA for the measurements of carnosinase concentrations

Autor: Hans Walter Zentgraf, Verena Peters, Frederick Pfister, Gerjan Navis, Dirk Frey, Katja Adelmann, Paula Sternik, Stephan J. L. Bakker, Jacob van den Born, Benito A. Yard, Eva Riedl, Stephanie Hofmann, Bernhard K. Krämer, Hannes Koeppel, Sibylle J. Hauske, Claus Peter Schmitt

Publikováno v: Amino Acids, 43(1), 143-151. SPRINGER WIEN

Serum carnosinase (CN-1) measurements are at present mainly performed by assessing enzyme activity. This method is time-consuming, not well suited for large series of samples and can be discordant to measurements of CN-1 protein concentrations. To ov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f78e0f400880b1d034578a5cd2a19c5f
https://pubmed.ncbi.nlm.nih.gov/22349764

Relevance of allosteric conformations and homocarnosine concentration on carnosinase activity

Autor: Verena Peters, Georg F. Hoffmann, Katja Adelmann, Erwin E. W. Jansen, Hannes Koeppel, Cornelis Jakobs, Moustafa Kebbewar, Matthias Mack, Bart Janssen, Dirk Frey, Johannes Zschocke, Eva Riedl, Kristina Klingbeil, Benito A. Yard

Publikováno v: Amino Acids, 38(5), 1607-1615. Springer Wien
Peters, V, Kebbewar, M, Jansen, E E W, Jakobs, C, Riedl, E, Koeppel, H, Frey, D, Adelmann, K, Klingbeil, K, Mack, M, Hoffmann, G F, Janssen, B, Zschocke, J & Yard, B A 2010, ' Relevance of allosteric conformations and homocarnosine concentration on carnosinase activity ', Amino Acids, vol. 38, no. 5, pp. 1607-1615 . https://doi.org/10.1007/s00726-009-0367-z

Activity of carnosinase (CN1), the only dipeptidase with substrate specificity for carnosine or homocarnosine, varies greatly between individuals but increases clearly and significantly with age. Surprisingly, the lower CN1 activity in children is no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4894429875725da4cbcfbd17248d34ae
https://research.vumc.nl/en/publications/6bfddaa5-863b-42c2-9f84-ffec891da6d1