KDM1A inhibition increases UVA toxicity and enhances photodynamic therapy efficacy

Autor: Shaila Mudambi, Megan Fitzgerald, Paula Pera, Deschana Washington, Sarah Chamberlain, Eszter Fidrus, Csaba Hegedűs, Eva Remenyik, Gal Shafirstein, David Bellnier, Gyorgy Paragh

Publikováno v: Photodermatology, photoimmunologyphotomedicineREFERENCES.

Lysine-specific histone demethylase 1 (KDM1A/LSD1) regulates multiple cellular functions, including cellular proliferation, differentiation, and DNA repair. KDM1A is overexpressed in squamous cell carcinoma of the skin and inhibition of KDM1A can sup

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3869d0c001bc3ca39052d36ce0d95b9
https://pubmed.ncbi.nlm.nih.gov/35968606

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Phase 3 Trials of Ixekizumab in Moderate-to-Severe Plaque Psoriasis

Autor: Gordon, K. B, Blauvelt, A., Papp, K. A., Langley, R. G., Luger, T., Ohtsuki, M., Reich, K., Amato, D., Ball, S. G., Braun, D. K., Cameron, G. S., Erickson, J., Konrad, R. J., Muram, T. M., Nickoloff, B. J., Osuntokun, O. O., Secrest, R. J., Zhao, F., Mallbris, L., Leonardi, C. L., Uncover, 1 Study Group: Holly Hake Harris, Matheson, Robert T., Michael, Bukhalo, John H., Tu, Crowley, Jeffrey J., Grande, Kimberly K., Adnan, Nasir, Boni Elizabeth Elewski, James Alan Solomon, Liebhild, Stratmann, Claudia, Buettner, Thomas Peter Dirschka, Margrit Ruth Simon, Jens, Ulrich, Christine, Grigat, Mathias, Augustin, Andrei, Khariouzov, Gerhard, Sattler, Hans Michael Ockenfels, Fredrick Richard Behringer, Hector, Wiltz, Francisco, Flores, Kuettel, Kevin D., Ira Hughes Thorla, Jeffrey Keith Moore, Waterman, Gary L., George Joji Murakawa, Scott Alfred Fretzin, Frankel, Ellen H., Sunil Sharan Dhawan, Lucyna, Leszniewska, Maria, Poznanska, Anna Sobieszek Kundro, Chodorowska, Grazyna M., Katarzyna Turek Urasinska, Romuald, Maleszka, Andrzej, Kaszuba, Lidia, Rajzer, Elizbieta Barbara Szymanska, Lidia, Rudnicka, Neil James Korman, Jamie Debra Weisman, Truett, Artis P., Jeffry, Jacqmein, Steven Robert Cohen, Heller, Gary L., Jenkin, Peter J., Abe, Marcadis, George Sorin Tiplica, Anca Aghinitei Zbranca Toporas, Simona Laura Ianosi, Ion, Florea, Claus, Zachariae, Lars, Iversen, Annalisa, Patrizi, Romanelli, Marco, Christopher, Griffiths, John Berth Jones, John, Foerster, Savin, Ronald C., Nelson, Christopher G., Lyn Carol Chamberlain Guenther, Albrecht, Lorne E., Hong, Chih ho H., Arnon, Katz, Mani, Raman, Adam, David N., Aamir, Butt, Stephen Peter Shumack, Kurt Aaron Josef Gebauer, Lynda Jane Spelman, Shireen Kaur Sidhu, Michael George Freeman, Peter Anthony Foley, Lajos, Kemeny, Eva, Remenyik, Zsuzsanna, Karolyi, Marc, Bourcier, Wayne Douglas Carey, Victoria, Taraska, Derek, Haaland, Aditya Kumar Gupta, Catherine, Maari, Darryl Paul Toth, Michael, Sebastian, Sandra, Philipp, Roland, Kaufmann, Diamant, Thaci, Thomas Andreas Werfel, Leila, Parise, Ingo, Haase, Petra Staubach Renz, Shinichi, Imafuku, Juichiro, Nakayama, Tadashi, Terui, Hideki, Nakajima, Shigetoshi, Sano, Uncover, 2 Study Group, Uncover, 3 Study Group

Publikováno v: New England Journal of Medicine. 375:345-356

BACKGROUND Two phase 3 trials (UNCOVER-2 and UNCOVER-3) showed that at 12 weeks of treatment, ixekizumab, a monoclonal antibody against interleukin-17A, was superior to placebo and etanercept in the treatment of moderate-to-severe psoriasis. We repor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fb30bf3a03c1849628a03f8c5fc3e43
https://doi.org/10.1056/nejmoa1512711

Molecular typing of human herpesvirus 8 isolates from patients with Kaposi's sarcoma in Hungary

Autor: Rita, Ötvös, Attila, Juhasz, Erika, Szalai, Dorina, Ujvari, Katalin, Ötvös, Katalin, Szabo, Eva, Remenyik, Laszlo, Szekely, Lajos, Gergely, Jozsef, Konya

Publikováno v: Anticancer research. 34(2)

Kaposi's sarcoma (KS) shows a distinct geographical and ethnic distribution. Genes at both ends of the human herpesvirus 8 (HHV-8) genome have been shown to vary considerably. Seven major molecular subtypes of HHV-8 were defined based on the amino ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b980e37a591dae0d59dc07b371c12f14
https://pubmed.ncbi.nlm.nih.gov/24511028

[The emotions of oncologists]

Autor: Kornélia, Lazányi, Péter, Molnár, Antal, Bugán, Csongor, Kiss, János, Szántó, Andrea, Gonda, Zoltán, Tóth, Zoltán, Hernádi, Janaki, Hadijev, Eva, Remenyik, László, Damjanovich, Tamás, Dinya, Tibor, Flaskó, Péter, Bágyi, Kornélia, Szluha

Publikováno v: Magyar onkologia. 55(3)

Emotions are parts of organizational reality to an ever increasing extent. Importantly, they are not just tools in the hand of healthcare workers to achieve better physician / healthcare professional-to-patient interactions but intrinsic processes an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2b03bd00efc09deb5318b846bc151ab9
https://pubmed.ncbi.nlm.nih.gov/21918747