Zobrazeno 1 - 10 of 15 pro vyhledávání: '"Eva Prchalova"'
1
Model Studies towards Prodrugs of the Glutamine Antagonist 6-Diazo-5-oxo-L-norleucine (DON) Containing a Diazo Precursor
Autor: Arindom Pal, Barbara S. Slusher, Jenny Lam, Eva Prchalova, Run-Duo Gao, Rana Rais, Niyada Hin, Takashi Tsukamoto
Publikováno v: Bioorg Med Chem Lett
Two distinct diazo precursors, imidazotetrazine and nitrous amide, were explored as promoieties in designing prodrugs of 6-diazo-5-oxo-l-norleucine (DON), a glutamine antagonist. As a model for an imidazotetrazine-based prodrug, we synthesized (S)-2-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f31284a499def3028a4e3df6ffd8b33
https://europepmc.org/articles/PMC8607733/
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2
Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion
Autor: Min Hee Oh, Jiayu Wen, Barbara S. Slusher, Ian A. Bettencourt, Im Hong Sun, Jesse Alt, Richard L. Blosser, Jonathan D. Powell, Robert Leone, Judson Englert, Chirag H. Patel, Im Meng Sun, Ada Tam, Eva Prchalova, Liang Zhao, Matthew L. Arwood, Rana Rais
Publikováno v: Science. 366:1013-1021
A fresh look at glutamine targetingGlutamine is essential for tumor growth and has long been an attractive therapeutic target for cancer researchers. Some attempts at blocking glutamine metabolism in cancer patients resulted in toxicity, prompting Le
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4925785a664b151cc3c2d33077dd3f0f
https://doi.org/10.1126/science.aav2588
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3
Glutamine Antagonist JHU-083 Normalizes Aberrant Hippocampal Glutaminase Activity and Improves Cognition in APOE4 Mice
Autor: Carolyn Tallon, Kevin Liaw, Kristen R. Hollinger, Ajit G. Thomas, Camilo Rojas, Sujatha Kannan, Ying Wu, Barbara S. Slusher, Xiaolei Zhu, Eva Prchalova, Atsushi Kamiya, Elizabeth S Khoury
Publikováno v: J Alzheimers Dis
Background: Given the emergent aging population, the identification of effective treatments for Alzheimer’s disease (AD) is critical. Objective: We investigated the therapeutic efficacy of JHU-083, a brain-penetrable glutamine antagonist, in treati
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b72af413042b9613254d54c30c3e9190
https://europepmc.org/articles/PMC7678030/
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4
JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress
Autor: Eva Prchalova, Michael T. Nedelcovych, Atsushi Saito, Ying Wu, Wade Coomer, Atsushi Kamiya, Yuto Hasegawa, Jesse Alt, Ajit G. Thomas, Barbara S. Slusher, Rana Rais, Gabriel Perez, Aisa Moreno-Megui, Lukáš Tenora, Camilo Rojas, Xiaolei Zhu, Varun Vohra, Pavel Majer
Publikováno v: Neuropsychopharmacology. 44:683-694
There are a number of clinically effective treatments for stress-associated psychiatric diseases, including major depressive disorder (MDD). Nonetheless, many patients exhibit resistance to first-line interventions calling for novel interventions bas
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a80a94b5aefe20013b30b956a38e1347
https://doi.org/10.1038/s41386-018-0177-7
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7
Correction: JHU-083 selectively blocks glutaminase activity in brain CD11b
Autor: Ajit G. Thomas, Rana Rais, Atsushi Saito, Atsushi Kamiya, Yuto Hasegawa, Aisa Moreno-Megui, Gabriel Perez, Barbara S. Slusher, Wade Coomer, Jesse Alt, Xiaolei Zhu, Lukáš Tenora, Camilo Rojas, Eva Prchalova, Ying Wu, Michael T. Nedelcovych, Varun Vohra, Pavel Majer
Publikováno v: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 44(6)
There are a number of clinically effective treatments for stress-associated psychiatric diseases, including major depressive disorder (MDD). Nonetheless, many patients exhibit resistance to first-line interventions calling for novel interventions bas
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a984c82d81f1f570eb5627ff4613ee60
https://pubmed.ncbi.nlm.nih.gov/30127344
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8
MRI demonstrates glutamine antagonist-mediated reversal of cerebral malaria pathology in mice
Autor: Susan K. Pierce, Louis H. Miller, Jeeva Munasinghe, Sanhita Sinharay, William Schreiber-Stainthorp, Eva Prchalova, Jonathan D. Powell, Dragan Maric, Dima A. Hammoud, Barbara S. Slusher, Brittany A. Riggle
Publikováno v: Proceedings of the National Academy of Sciences. 115
The deadliest complication of Plasmodium falciparum infection is cerebral malaria (CM), with a case fatality rate of 15 to 25% in African children despite effective antimalarial chemotherapy. No adjunctive treatments are yet available for this devast
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc977d2b289098b4a18c2d459b383529
https://doi.org/10.1073/pnas.1812909115
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10
N-Substituted Prodrugs of Mebendazole Provide Improved Aqueous Solubility and Oral Bioavailability in Mice and Dogs
Autor: Andrej Jančařík, Rana Rais, Lenka Monincová, Ranjeet Prasad Dash, Sarah C. Zimmermann, Barbara S. Slusher, Gregory J. Riggins, Jan Vávra, Pavel Majer, Alexandra J. Gadiano, Ying Wu, Lukáš Tenora, C. Ethan Slusher, Tomáš Tichý, Eva Prchalova
Publikováno v: Journal of medicinal chemistry. 61(9)
Mebendazole (MBZ) was developed as a broad-spectrum anthelmintic but has recently shown efficacy as an anticancer agent. The use of MBZ for cancer, however, is challenging due to its poor solubility leading to poor bioavailability. Herein, we develop
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ac964951d4f54e1ee534f7ef732a480
https://pubmed.ncbi.nlm.nih.gov/29648826
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